Bicycle Therapeutics
Head of Compliance & Ethics
Bicycle Therapeutics, Cambridge, Massachusetts, us, 02140
Company Description
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.
Culture is key and all Bicycle employees actively embrace and role model our company values:
We are Adventurous . We believe it’s the way to deliver extraordinary results for our patients.
We are Dedicated to our Mission . You can’t change the world if you don’t have determination.
We are One Team . We only succeed when we work together.
Job Description
The Head of Compliance & Ethics will play a critical strategic role in building and leading the company’s compliance and ethics program, reporting to the Chief Legal Officer & General Counsel and working closely with the Executive Team. You will ensure that all corporate activities—especially those related to clinical development, medical affairs, and commercial operations—adhere to the highest legal and ethical standards. You will work cross-functionally to embed compliance principles into everyday operations, mitigating risk while fostering a culture of ethics and integrity across the organization as we scale and approach potential commercialization.
Key responsibilities:
The Head of Compliance & Ethics serves as the key contact on issues relating to the implementation of and compliance with Bicycle’s Code of Business Conduct & Ethics and related policies
Develop, implement, and maintain a comprehensive healthcare and corporate compliance and ethics program, ensuring alignment across all functions, including clinical development, medical affairs, and commercial teams
Ensure compliance with global healthcare and corporate compliance related requirements, industry standards, and internal policies across all functions
Partner with cross-functional teams to embed ethical decision-making into clinical trials, product development, and commercial strategies
Lead healthcare and corporate compliance training programs tailored to the unique needs of the company
Oversee healthcare and corporate compliance based risk assessments and internal audits/monitoring to proactively identify and address compliance vulnerabilities
Collaborate with leadership to integrate compliance into strategic decision-making processes
Manage reporting, investigations, and resolution of compliance violations
Working closely with Regulatory Affairs teams, stay up to date with international and regional laws and regulations and ensure the company's adherence to these requirements
Qualifications
Proven experience in healthcare and corporate compliance leadership within the biotech or pharmaceutical industry
Strong understanding of compliance requirements, including across clinical development, medical affairs, and commercial operations
Exceptional strategic thinking, with the ability to build and integrate compliance programs across multiple functions
Demonstrated ability to work cross-functionally and influence diverse teams and leadership
Strong knowledge of global regulatory and compliance standards (e.g., FDA, EMA) and healthcare laws
Excellent leadership, communication, and interpersonal skills
Additional Information
Flexible working environment
Competitive reward including annual company bonus
Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
Health and Dependent Care Flexible Spending Accounts
401(k) plan with a 4% Company match and immediate vesting
Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
Employee assistance program
Employee recognition schemes
10 Company holidays
Competitive Family Leave Policy
Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.
Culture is key and all Bicycle employees actively embrace and role model our company values:
We are Adventurous . We believe it’s the way to deliver extraordinary results for our patients.
We are Dedicated to our Mission . You can’t change the world if you don’t have determination.
We are One Team . We only succeed when we work together.
Job Description
The Head of Compliance & Ethics will play a critical strategic role in building and leading the company’s compliance and ethics program, reporting to the Chief Legal Officer & General Counsel and working closely with the Executive Team. You will ensure that all corporate activities—especially those related to clinical development, medical affairs, and commercial operations—adhere to the highest legal and ethical standards. You will work cross-functionally to embed compliance principles into everyday operations, mitigating risk while fostering a culture of ethics and integrity across the organization as we scale and approach potential commercialization.
Key responsibilities:
The Head of Compliance & Ethics serves as the key contact on issues relating to the implementation of and compliance with Bicycle’s Code of Business Conduct & Ethics and related policies
Develop, implement, and maintain a comprehensive healthcare and corporate compliance and ethics program, ensuring alignment across all functions, including clinical development, medical affairs, and commercial teams
Ensure compliance with global healthcare and corporate compliance related requirements, industry standards, and internal policies across all functions
Partner with cross-functional teams to embed ethical decision-making into clinical trials, product development, and commercial strategies
Lead healthcare and corporate compliance training programs tailored to the unique needs of the company
Oversee healthcare and corporate compliance based risk assessments and internal audits/monitoring to proactively identify and address compliance vulnerabilities
Collaborate with leadership to integrate compliance into strategic decision-making processes
Manage reporting, investigations, and resolution of compliance violations
Working closely with Regulatory Affairs teams, stay up to date with international and regional laws and regulations and ensure the company's adherence to these requirements
Qualifications
Proven experience in healthcare and corporate compliance leadership within the biotech or pharmaceutical industry
Strong understanding of compliance requirements, including across clinical development, medical affairs, and commercial operations
Exceptional strategic thinking, with the ability to build and integrate compliance programs across multiple functions
Demonstrated ability to work cross-functionally and influence diverse teams and leadership
Strong knowledge of global regulatory and compliance standards (e.g., FDA, EMA) and healthcare laws
Excellent leadership, communication, and interpersonal skills
Additional Information
Flexible working environment
Competitive reward including annual company bonus
Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
Health and Dependent Care Flexible Spending Accounts
401(k) plan with a 4% Company match and immediate vesting
Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
Employee assistance program
Employee recognition schemes
10 Company holidays
Competitive Family Leave Policy
Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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