Vertex Ventures HC
Manager, Procurement
Vertex Ventures HC, Oklahoma City, Oklahoma, United States,
Company Description
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (previously BT8009), a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology. Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Massachusetts. Culture
is key and all Bicycle employees actively embrace and role model our company values: We are
Adventurous . We believe it’s the way to deliver extraordinary results for our patients. We are
Dedicated to our Mission . You can’t change the world if you don’t have determination. We are
One Team . We only succeed when we work together. Job Description
Bicycle Therapeutics is hiring for a newly created Procurement Manager role to help support the CMC function of our company. As a vital member of the team, you will help lead the CMC supplier management process, which includes creating & coordinating routine business reviews, leading escalation meetings, and resolving business action items. In addition to leading the CMC supplier management process, this role will help identify and implement continuous improvement elements to our RFI/RFP process. Key responsibilities: Lead the CMC supplier management process, including the coordinating routine business reviews, escalation meetings, and ultimate action item follow-up Build and report out a strategic view of the supplier business relationship. Evaluate the supply quality, and compliance of our entire CMC supply base Create and oversee the cadence of a set schedule of both in-person and virtual meetings is across CMC programs Responsible for generating & coordinating business review pre-reads, meeting notes, and action item logs for each business review Assist in Request for Information (RFI) and Request for Proposal (RFP) documentation process Assist in the compilation and distribution of Key Performance Indicators (KPI’s) from Bicycle suppliers Review and draft CMC vendor policy documentation Support vendor onboarding activities Support the Purchasing Order and Contract Approval Form (CAF) sourcing process Act as a key liaison between Procurement and other cross-functional teams/stakeholders Qualifications
Essential: Knowledge of Chemistry, Manufacturing and Controls (CMC) Experience in Supplier Relationship Management (SRM) Ability to build consensus among internal stakeholders History of working with and/or establishing an end-to-end sourcing process Understanding of Procurement policies and guidelines Desirable: Highly collaborative, strong relationship building skills with a high level of integrity and emotional intelligence. First class communication and influencing skills with the ability to manage multiple stakeholders. Resilient and able to work effectively in a demanding and fast-paced environment. Understanding of supplier GMP requirements Worked within an international and/or hybrid team dynamic Other: Hybrid base role. Expectations of at least one day per week in Cambridge USA office Less than 10% domestic travel considerations CPSM or APICS certification preferred Six Sigma certification preferred Educated in Supply Chain Management preferred Additional Information
Flexible working environment Competitive reward including annual company bonus Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company Health and Dependent Care Flexible Spending Accounts 401(k) plan with a 4% Company match and immediate vesting Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days Employee assistance program Employee recognition schemes 10 Company holidays Competitive Family Leave Policy Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (previously BT8009), a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology. Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Massachusetts. Culture
is key and all Bicycle employees actively embrace and role model our company values: We are
Adventurous . We believe it’s the way to deliver extraordinary results for our patients. We are
Dedicated to our Mission . You can’t change the world if you don’t have determination. We are
One Team . We only succeed when we work together. Job Description
Bicycle Therapeutics is hiring for a newly created Procurement Manager role to help support the CMC function of our company. As a vital member of the team, you will help lead the CMC supplier management process, which includes creating & coordinating routine business reviews, leading escalation meetings, and resolving business action items. In addition to leading the CMC supplier management process, this role will help identify and implement continuous improvement elements to our RFI/RFP process. Key responsibilities: Lead the CMC supplier management process, including the coordinating routine business reviews, escalation meetings, and ultimate action item follow-up Build and report out a strategic view of the supplier business relationship. Evaluate the supply quality, and compliance of our entire CMC supply base Create and oversee the cadence of a set schedule of both in-person and virtual meetings is across CMC programs Responsible for generating & coordinating business review pre-reads, meeting notes, and action item logs for each business review Assist in Request for Information (RFI) and Request for Proposal (RFP) documentation process Assist in the compilation and distribution of Key Performance Indicators (KPI’s) from Bicycle suppliers Review and draft CMC vendor policy documentation Support vendor onboarding activities Support the Purchasing Order and Contract Approval Form (CAF) sourcing process Act as a key liaison between Procurement and other cross-functional teams/stakeholders Qualifications
Essential: Knowledge of Chemistry, Manufacturing and Controls (CMC) Experience in Supplier Relationship Management (SRM) Ability to build consensus among internal stakeholders History of working with and/or establishing an end-to-end sourcing process Understanding of Procurement policies and guidelines Desirable: Highly collaborative, strong relationship building skills with a high level of integrity and emotional intelligence. First class communication and influencing skills with the ability to manage multiple stakeholders. Resilient and able to work effectively in a demanding and fast-paced environment. Understanding of supplier GMP requirements Worked within an international and/or hybrid team dynamic Other: Hybrid base role. Expectations of at least one day per week in Cambridge USA office Less than 10% domestic travel considerations CPSM or APICS certification preferred Six Sigma certification preferred Educated in Supply Chain Management preferred Additional Information
Flexible working environment Competitive reward including annual company bonus Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company Health and Dependent Care Flexible Spending Accounts 401(k) plan with a 4% Company match and immediate vesting Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days Employee assistance program Employee recognition schemes 10 Company holidays Competitive Family Leave Policy Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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