CALICO
Senior/Principal Scientist, Translational Physiology
CALICO, South San Francisco, California, us, 94083
Who We Are:
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Position Description:
Calico is seeking a highly motivated Senior/Principal Scientist to join our Translational Physiology team. The successful candidate will lead our preclinical
in vivo
pharmacology efforts across one or more disease pathology areas, including but not limited to inflammation-, fibrosis- or metabolism-related diseases. This role will focus on developing program-specific strategies, pharmacodynamics/efficacy models, and establishing preclinical
in vivo
pharmacology proof-of-concept (PoC) and pharmacokinetic/pharmacodynamic (PK/PD) relationships within our Translational Aging programs.
Key Responsibilities:
Lead preclinical
in vivo
pharmacology studies in selected disease pathology areas, including inflammation, fibrosis, and/or metabolic disorders
Design and execute pharmacodynamic (PD) and efficacy models tailored to the specific needs of each program
Establish preclinical
in vivo
PoC and PK/PD relationships to support translational research
Contribute to the development of preclinical strategies to advance the Translational Aging programs
Collaborate closely with cross-functional teams to ensure timely execution and success of projects
Prepare and present research findings to project teams and leadership.
Write research articles for peer-reviewed publications
Position Requirements:
PhD or equivalent in Physiology, Immunology, Pharmacology, or a related field, with 5-8 years of relevant research and/or drug discovery experience
Extensive experience with
in vivo
disease model development and characterization
Strong analytical and problem-solving skills with the ability to navigate challenges within project timelines
Demonstrated success in working within cross-functional teams in a collaborative environment
Thorough knowledge of IACUC guidelines/regulations and experience in writing animal use protocols, experimental study design protocols, and standard operating procedures for preclinical studies
Excellent communication skills, both verbal and written, with the ability to present research findings clearly at team meetings
Must be willing to work onsite five days a week
The estimated base salary range for this role is $163,000 - $201,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
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Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Position Description:
Calico is seeking a highly motivated Senior/Principal Scientist to join our Translational Physiology team. The successful candidate will lead our preclinical
in vivo
pharmacology efforts across one or more disease pathology areas, including but not limited to inflammation-, fibrosis- or metabolism-related diseases. This role will focus on developing program-specific strategies, pharmacodynamics/efficacy models, and establishing preclinical
in vivo
pharmacology proof-of-concept (PoC) and pharmacokinetic/pharmacodynamic (PK/PD) relationships within our Translational Aging programs.
Key Responsibilities:
Lead preclinical
in vivo
pharmacology studies in selected disease pathology areas, including inflammation, fibrosis, and/or metabolic disorders
Design and execute pharmacodynamic (PD) and efficacy models tailored to the specific needs of each program
Establish preclinical
in vivo
PoC and PK/PD relationships to support translational research
Contribute to the development of preclinical strategies to advance the Translational Aging programs
Collaborate closely with cross-functional teams to ensure timely execution and success of projects
Prepare and present research findings to project teams and leadership.
Write research articles for peer-reviewed publications
Position Requirements:
PhD or equivalent in Physiology, Immunology, Pharmacology, or a related field, with 5-8 years of relevant research and/or drug discovery experience
Extensive experience with
in vivo
disease model development and characterization
Strong analytical and problem-solving skills with the ability to navigate challenges within project timelines
Demonstrated success in working within cross-functional teams in a collaborative environment
Thorough knowledge of IACUC guidelines/regulations and experience in writing animal use protocols, experimental study design protocols, and standard operating procedures for preclinical studies
Excellent communication skills, both verbal and written, with the ability to present research findings clearly at team meetings
Must be willing to work onsite five days a week
The estimated base salary range for this role is $163,000 - $201,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
#J-18808-Ljbffr