Merck Sharp & Dohme
Principal Scientist, In Vivo Pharmacology
Merck Sharp & Dohme, South San Francisco, California, us, 94083
Job Description
At our company, we are committed to improving the health and well-being of people around the world. As a leading global pharmaceutical company, we strive to make a difference through innovative research and development of life-saving medications and vaccines. Our company's Research Laboratories in South San Francisco is seeking a Principal Scientist of In vivo Pharmacology with strong experience in cardiovascular and metabolic diseases to join our Quantitative Biosciences (Pharmacology) department as an in vivo team lead. Working collaboratively with multidisciplinary scientists and through your team, you will apply your knowledge of translational models for cardiometabolic diseases, in vivo technology platforms, and data science to advance diverse therapeutic programs. If you are lab-focused, scientifically curious, and looking to develop your career at a leading science driven pharmaceutical company, we'd love for you to be part of our diverse and passionate team.
Key responsibilities:
Develop and support in vivo pharmacology strategies for obesity, immuno-metabolic, and cardiovascular diseases to enable a robust drug discovery pipeline.
Lead translational model development and implementation to support target engagement, pharmacodynamics, or efficacy studies.
Serve as a core member in matrixed project teams and governance committees to drive in vivo pharmacology strategy and provide scientific/technical leadership.
Ensure high-quality data generation, analysis, and reporting to project teams, governance committees, and regulatory agencies, and manage key timelines and milestones.
Lead and develop a group of PhD and non-PhD researchers, drive scientific innovation, and champion new enabling technologies to enhance functional capability and productivity.
Monitor emerging biology, biomarker, as well as basic & clinical research in cardiometabolic disorders to influence portfolio development strategy.
Collaborate extensively across our company's network and with external partners to drive pipeline progression toward key milestones.
Qualifications:
Education:
Ph.D. in biology, pharmacology, metabolism, immunology or related discipline and relevant industry experience listed below.
Required Experience and Skills:
A minimum of 10 years of drug discovery experience at a biotech or pharmaceutical setting in obesity, dysmetabolism, diabetes and cardiovascular complications, with a proven track record substantiated by peer-reviewed publications and/or patents.
A solid understanding of cardiometabolic disease pathogenesis and extensive experience in developing relevant in vivo models including both small and large animals.
Experience leading discovery teams, overseeing in vivo strategy, setting project priorities, and managing resources.
A robust understanding of preclinical drug discovery and clinical development.
An excellent track record of providing mentorship to direct reports and influencing peers.
The ability to communicate effectively with and relate to a broad range of stakeholders, including senior leaders, peers, direct reports, partners, and external collaborators.
Preferred Experience and Skills:
Strong knowledge of biomarker discovery, translational research, and data science.
Prior experience working with multiple therapeutic modalities (small molecule, peptide, biologic, etc.).
Employee Status:
Regular
Relocation:
Domestic/International
VISA Sponsorship:
Yes
Travel Requirements:
10%
Shift:
1st - Day
Job Posting End Date:
10/31/2024
#J-18808-Ljbffr
At our company, we are committed to improving the health and well-being of people around the world. As a leading global pharmaceutical company, we strive to make a difference through innovative research and development of life-saving medications and vaccines. Our company's Research Laboratories in South San Francisco is seeking a Principal Scientist of In vivo Pharmacology with strong experience in cardiovascular and metabolic diseases to join our Quantitative Biosciences (Pharmacology) department as an in vivo team lead. Working collaboratively with multidisciplinary scientists and through your team, you will apply your knowledge of translational models for cardiometabolic diseases, in vivo technology platforms, and data science to advance diverse therapeutic programs. If you are lab-focused, scientifically curious, and looking to develop your career at a leading science driven pharmaceutical company, we'd love for you to be part of our diverse and passionate team.
Key responsibilities:
Develop and support in vivo pharmacology strategies for obesity, immuno-metabolic, and cardiovascular diseases to enable a robust drug discovery pipeline.
Lead translational model development and implementation to support target engagement, pharmacodynamics, or efficacy studies.
Serve as a core member in matrixed project teams and governance committees to drive in vivo pharmacology strategy and provide scientific/technical leadership.
Ensure high-quality data generation, analysis, and reporting to project teams, governance committees, and regulatory agencies, and manage key timelines and milestones.
Lead and develop a group of PhD and non-PhD researchers, drive scientific innovation, and champion new enabling technologies to enhance functional capability and productivity.
Monitor emerging biology, biomarker, as well as basic & clinical research in cardiometabolic disorders to influence portfolio development strategy.
Collaborate extensively across our company's network and with external partners to drive pipeline progression toward key milestones.
Qualifications:
Education:
Ph.D. in biology, pharmacology, metabolism, immunology or related discipline and relevant industry experience listed below.
Required Experience and Skills:
A minimum of 10 years of drug discovery experience at a biotech or pharmaceutical setting in obesity, dysmetabolism, diabetes and cardiovascular complications, with a proven track record substantiated by peer-reviewed publications and/or patents.
A solid understanding of cardiometabolic disease pathogenesis and extensive experience in developing relevant in vivo models including both small and large animals.
Experience leading discovery teams, overseeing in vivo strategy, setting project priorities, and managing resources.
A robust understanding of preclinical drug discovery and clinical development.
An excellent track record of providing mentorship to direct reports and influencing peers.
The ability to communicate effectively with and relate to a broad range of stakeholders, including senior leaders, peers, direct reports, partners, and external collaborators.
Preferred Experience and Skills:
Strong knowledge of biomarker discovery, translational research, and data science.
Prior experience working with multiple therapeutic modalities (small molecule, peptide, biologic, etc.).
Employee Status:
Regular
Relocation:
Domestic/International
VISA Sponsorship:
Yes
Travel Requirements:
10%
Shift:
1st - Day
Job Posting End Date:
10/31/2024
#J-18808-Ljbffr