Genentech
Principal Scientist, Toxicologist
Genentech, South San Francisco, California, us, 94083
The Position
We advance science so that we all have more time with the people we love.The Department of Safety Assessment at Genentech is seeking a highly motivated toxicologist for a Principal Scientist role to lead nonclinical studies and safety strategies in the process of drug development from discovery through marketed products. This position requires a solid track record of scientific productivity and strong leadership in strategic planning and execution in the areas of toxicology.The Opportunity:This project team-facing role involves close collaboration with departmental colleagues and cross-functional teams across developmental stages, molecular modalities and therapeutic areas. The team member will lead projects and demonstrate appropriate decision-making capabilities that take into account cross-functional aspects, understand the impact of such decisions and design, conduct and integrate findings of toxicology programs in support of drug candidate development at Genentech.You will create a best-evidence based synthesis of existing knowledge and comprehensive investigations of toxicologic activity.You will design and supervise in vitro and in vivo toxicology studies, work closely with study monitors, pathologists and pharmacokinetic scientists, biomarker scientists, clinical scientists, etc., to deliver high quality GLP and non-GLP study reports and represent Genentech in meetings with regulatory authorities, as needed.You will participate in interdisciplinary project teams, prepare and review regulatory documentation, study reports and manuscripts, participate in toxicology and pharmacology initiatives, as well as other active cross-functional collaborations.You will lead hypothesis-driven investigation into mechanisms of toxicity, proactively lead potential safety liabilities and communicate impact to teams and governance committees.You will socialize complex science-based messages and processes at all levels within the department and across the organization.You will implement above responsibilities through informed interpretation and compliance with evolving global and company regulations and guidances, including outreach, education and alignment of practices with internal stakeholders.You will mentor and develop internal staff or peers, as appropriate.Who You Are:PhD plus post-doc or equivalent experience in toxicology or related subject area.3-7 years of professional experience in the biopharmaceutical/CRO industry.Experience in immunology and/or immunotoxicology and board certification in toxicology are highly desirable.Solid track record of scientific productivity (i.e. publications, conference presentations, etc.), and strong scientific leadership in strategic planning and execution in the areas of toxicology.Demonstrate strong decision-making, sophisticated problem solving, project management, critical data analysis and interpretation skills.Qualifications or special skills that include strategic program development and leadership, collaboration, influencing/negotiating skills, etc. are a must.Excellent verbal and written communication skills, including strong technical writing and presentations.Relocation benefits are available for this job posting.Onsite presence, on our South San Francisco campus, is expected for at least 3 days a week.The expected salary range for this position based on the primary location of California is $141,500 - $262,900 of hiring range. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.BenefitsGenentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
#J-18808-Ljbffr
We advance science so that we all have more time with the people we love.The Department of Safety Assessment at Genentech is seeking a highly motivated toxicologist for a Principal Scientist role to lead nonclinical studies and safety strategies in the process of drug development from discovery through marketed products. This position requires a solid track record of scientific productivity and strong leadership in strategic planning and execution in the areas of toxicology.The Opportunity:This project team-facing role involves close collaboration with departmental colleagues and cross-functional teams across developmental stages, molecular modalities and therapeutic areas. The team member will lead projects and demonstrate appropriate decision-making capabilities that take into account cross-functional aspects, understand the impact of such decisions and design, conduct and integrate findings of toxicology programs in support of drug candidate development at Genentech.You will create a best-evidence based synthesis of existing knowledge and comprehensive investigations of toxicologic activity.You will design and supervise in vitro and in vivo toxicology studies, work closely with study monitors, pathologists and pharmacokinetic scientists, biomarker scientists, clinical scientists, etc., to deliver high quality GLP and non-GLP study reports and represent Genentech in meetings with regulatory authorities, as needed.You will participate in interdisciplinary project teams, prepare and review regulatory documentation, study reports and manuscripts, participate in toxicology and pharmacology initiatives, as well as other active cross-functional collaborations.You will lead hypothesis-driven investigation into mechanisms of toxicity, proactively lead potential safety liabilities and communicate impact to teams and governance committees.You will socialize complex science-based messages and processes at all levels within the department and across the organization.You will implement above responsibilities through informed interpretation and compliance with evolving global and company regulations and guidances, including outreach, education and alignment of practices with internal stakeholders.You will mentor and develop internal staff or peers, as appropriate.Who You Are:PhD plus post-doc or equivalent experience in toxicology or related subject area.3-7 years of professional experience in the biopharmaceutical/CRO industry.Experience in immunology and/or immunotoxicology and board certification in toxicology are highly desirable.Solid track record of scientific productivity (i.e. publications, conference presentations, etc.), and strong scientific leadership in strategic planning and execution in the areas of toxicology.Demonstrate strong decision-making, sophisticated problem solving, project management, critical data analysis and interpretation skills.Qualifications or special skills that include strategic program development and leadership, collaboration, influencing/negotiating skills, etc. are a must.Excellent verbal and written communication skills, including strong technical writing and presentations.Relocation benefits are available for this job posting.Onsite presence, on our South San Francisco campus, is expected for at least 3 days a week.The expected salary range for this position based on the primary location of California is $141,500 - $262,900 of hiring range. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.BenefitsGenentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
#J-18808-Ljbffr