Cue Biopharma, Inc
Senior Associate Scientist/Scientist – Discovery and Translational Immunology
Cue Biopharma, Inc, Boston, Massachusetts, us, 02298
Senior Associate Scientist/Scientist – Discovery and Translational Immunology
The Company Cue Biopharma, Inc., a clinical-stage biopharmaceutical company, is developing a novel class of therapeutic biologics to selectively engage and modulate disease-specific T cells to transform the treatment of cancer and autoimmune diseases. Cue Biopharma is a high growth company and is listed on NASDAQ: CUE. The company is located in Boston, Massachusetts in the heart of the life sciences corridor. Cue Biopharma is building a world-class team of highly motivated, dedicated scientists to help advance its research and development programs. The company culture is fast-paced and committed to scientific excellence, innovation and teamwork. We are looking for a motivated Senior Associate Scientist/Scientist to join our Discovery and Translational Immunology team. The successful candidate will provide key mechanistic, preclinical, and translational immunology support for Cue Biopharma’s growing pipeline of therapeutic candidates for the treatment of cancer and autoimmune disease. The successful candidate will also contribute to understanding the breadth of disease-relevant T-cell receptor (TCR) repertoires as well as to generating and interrogating TCR-transduced human cell lines and primary human T cells. Responsibilities Plan, execute and analyze
in vitro / ex vivo
studies using primary human immune cells (from healthy donors and patients). Perform immunophenotyping using multicolor flow cytometry, FACS, and cellular immunology assays. Isolation, viral transduction and culture of primary human/non-human PBMCs and immune cell subsets. Expansion, selection and long-term maintenance of T cell clones/lines. Contribute to all aspects of generating TCR lentiviral/retroviral vectors including design, construction and testing. Conduct experiments and accurately document and effectively communicate data with project team, colleagues and manager. Contribute collaboratively to team efforts to achieve experimental and organizational goals. Requirements Ph.D. in Immunology or a relevant field with 0-5 years of related laboratory experience, M.S. in a relevant field with 2-7+ years of related laboratory experience, or B.S. in a relevant field with 5-9+ years of related laboratory experience. Hands-on experience executing and documenting
in vitro
biology studies of primary human immune cells is required. Multicolor flow cytometry-based immunophenotyping, FACS, cellular immunology
in vitro
assays (i.e., cytokine analysis, cytotoxicity, and proliferation) is highly desirable. Hands-on experience analyzing antigen-specific T cells is a plus. Direct experience with molecular biology, lentiviral/retroviral vectors, synthetic biology and assay development is highly desirable. Hands-on experience generating stably transduced T cell lines and primary T cells; knowledge of TCR V(D)J recombination is a plus but not required. Experience with B cells, granulocytes, and/or therapeutic targeting in the context of autoimmunity is a plus. Scientifically rigorous, highly organized and displays significant attention to detail. Self-motivated and able to work independently. Team and goal-oriented scientist with excellent oral and written communication skills who enjoys working in a fast-paced, small-company environment.
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The Company Cue Biopharma, Inc., a clinical-stage biopharmaceutical company, is developing a novel class of therapeutic biologics to selectively engage and modulate disease-specific T cells to transform the treatment of cancer and autoimmune diseases. Cue Biopharma is a high growth company and is listed on NASDAQ: CUE. The company is located in Boston, Massachusetts in the heart of the life sciences corridor. Cue Biopharma is building a world-class team of highly motivated, dedicated scientists to help advance its research and development programs. The company culture is fast-paced and committed to scientific excellence, innovation and teamwork. We are looking for a motivated Senior Associate Scientist/Scientist to join our Discovery and Translational Immunology team. The successful candidate will provide key mechanistic, preclinical, and translational immunology support for Cue Biopharma’s growing pipeline of therapeutic candidates for the treatment of cancer and autoimmune disease. The successful candidate will also contribute to understanding the breadth of disease-relevant T-cell receptor (TCR) repertoires as well as to generating and interrogating TCR-transduced human cell lines and primary human T cells. Responsibilities Plan, execute and analyze
in vitro / ex vivo
studies using primary human immune cells (from healthy donors and patients). Perform immunophenotyping using multicolor flow cytometry, FACS, and cellular immunology assays. Isolation, viral transduction and culture of primary human/non-human PBMCs and immune cell subsets. Expansion, selection and long-term maintenance of T cell clones/lines. Contribute to all aspects of generating TCR lentiviral/retroviral vectors including design, construction and testing. Conduct experiments and accurately document and effectively communicate data with project team, colleagues and manager. Contribute collaboratively to team efforts to achieve experimental and organizational goals. Requirements Ph.D. in Immunology or a relevant field with 0-5 years of related laboratory experience, M.S. in a relevant field with 2-7+ years of related laboratory experience, or B.S. in a relevant field with 5-9+ years of related laboratory experience. Hands-on experience executing and documenting
in vitro
biology studies of primary human immune cells is required. Multicolor flow cytometry-based immunophenotyping, FACS, cellular immunology
in vitro
assays (i.e., cytokine analysis, cytotoxicity, and proliferation) is highly desirable. Hands-on experience analyzing antigen-specific T cells is a plus. Direct experience with molecular biology, lentiviral/retroviral vectors, synthetic biology and assay development is highly desirable. Hands-on experience generating stably transduced T cell lines and primary T cells; knowledge of TCR V(D)J recombination is a plus but not required. Experience with B cells, granulocytes, and/or therapeutic targeting in the context of autoimmunity is a plus. Scientifically rigorous, highly organized and displays significant attention to detail. Self-motivated and able to work independently. Team and goal-oriented scientist with excellent oral and written communication skills who enjoys working in a fast-paced, small-company environment.
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