Research Scientist/Research Scientist II/Senior Research Scientist, Gene Therapy

Please note that we are open to position level for this position and can consider candidates at the Scientist up to Senior Scientist level. Title will be dependent on education and experience. Your Impact Poseida is at the forefront of the next generation in genetic medicines. We are developing complex drugs requiring scientists with a thirst for innovation and a wide range of technical backgrounds. You'll work in an exciting fast-paced environment alongside organic chemists synthesizing novel nanomaterials, formulation scientists devising non-viral delivery platforms, molecular biologists inventing genome engineering tools, and pharmacologists discovering how to deploy Poseida's innovative gene therapy modalities. Your assays will be used to identify promising new nano formulations and treatment strategies, as well as to characterize the performance of our genetic medicines' therapeutic candidates, such as for Hemophilia A. Our objective at Poseida is to enable genetic medicines that provide cures to severe disease early in life and the potential for curing more common diseases in the future; this is your opportunity to use your ingenuity to be a change maker in how we think about and approach the next generation of therapeutics. Position Summary Poseida Therapeutics, Inc. is searching for an outstanding Scientist (Research Scientist I, Research Scientist II or Sr. Research Scientist) to join our Gene Therapy team in San Diego, CA. This position offers an exciting opportunity to discover and develop next-generation products using Poseida's best-in-class genome editing, gene insertion, and delivery technologies. This role will manage and execute in vivo and in vitro pharmacology work from discovery to drug candidate nomination, and IND-enabling activities working closely with formulations, analytical chemistry, molecular engineering, and translational teams. Experience with Hemophilia A, gene therapies, and/or LNP delivery is highly valued. Responsibilities These may include but are not limited to: Lead in vivo pharmacology activities in rodents and large animals for Poseida's in vivo genetic medicines team, comprising platform discovery, feasibility assessment, therapeutic proof-of-concept, and candidate nomination. Plan and execute studies in rodents and large animals to characterize the in vivo pharmacology (PK/PD, biodistribution), toxicology, safety, and efficacy of Poseida's genetic medicines systems, including hands-on work designing/validating/implementing in vivo disease models. Lead, design, execute bioanalytical assays relevant to the target disease(s). Support internal Formulations and Analytical teams in the design and execution of experiments related to product analytical method development and bioassay development. Work closely with Poseida's Formulations, Molecular Biology, and Chemistry teams in the design of next-generation genetic medicine platforms. Stay abreast of new gene therapy platform and mechanistic results from Poseida and other companies. Work effectively with internal and outsourced animal resources to manage disease model generation, colony maintenance, study execution, and data analysis. Work effectively with Poseida Project Management teams to set, maintain and manage program timelines and deliverables. Author study design protocols, technical reports, and contribute to regulatory filings. Analyze data and report to multidisciplinary groups. Attend scientific meetings, critically evaluate data, and present scientific results. Keep current on trends, new products and technologies in the gene therapy and gene editing fields. Manage 1-4 Research Technicians, Research Associates, and/or Junior Scientists, as needed. Local travel to and from Poseida office and Vivarium is required. Requirements, Knowledge, Skills, and Abilities Research Scientist I - Ph.D. in a scientific discipline (e.g., molecular biology, cell biology, pharmacology, toxicology, immunology, or other relevant scientific field) with up zero to two years of relevant experience (an equivalent combination of education and experience may be considered). Research Scientist II - Ph.D. in a scientific discipline (e.g., molecular biology, cell biology, pharmacology, toxicology, immunology, or other relevant scientific field) with up two to five years of relevant experience (an equivalent combination of education and experience may be considered). Senior Research Scientist - Ph.D with 5+ years of relevant industry experience (an equivalent combination of education and experience may be considered). Preference for demonstrated experience in transitioning one or more gene therapy program(s) from feasibility through disease proof-of-concept and/or candidate nomination. Preference for background/certification in toxicology. Strong hands-on experience with complex drug formulations, such as nanoparticles and viral vectors, for in vivo gene therapy. Demonstrated expertise in the biology and relevant animal models of at least one of the following classes of genetic diseases: urea cycle disorders, inborn errors of amino acid, carbohydrate, or lipid metabolism, organic acidemia, lysosomal storage disorders, or congenital hematologic diseases, strong preference for experience with Hemophilia. Experience with routine assays (qPCR and/or ddPCR, immune-staining (IHC/IFC), immunoassays (ELISA, MSD, Luminex) and Western blot) is highly desirable. Familiarity with USDA, PHS, and AAALAC guidance on use of animals in research. Must be highly motivated and capable of working in a multidisciplinary team environment with scientists and external collaborators. Excellent written and verbal communications skills, and the ability to present and defend positions and approaches critical to program progression and success. Critical-thinker and detail-focused manager with a desire to lead, inspire, and discover in the context of team-based cross-functional science. Research Scientist pay range (PhD with 0 to 2 years): $108,000 - $120,000 Research Scientist II pay range (PhD with 2 to 5 years): $117,000 - $135,000 Senior Research Scientist: (PhD with 5 plus years) $130,000 - $150,000 The final pay offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience with the industry, education, geographic location, etc. Who We Are and What We Do Based in San Diego, Poseida Therapeutics is a clinical-stage biopharmaceutical company utilizing our unique and proprietary genetic engineering platform technologies to create next-generation cell and gene therapies with the capacity to cure. We are passionate about making an impact on patients' lives with the development of our CAR-T therapies in various cancers and gene therapies for rare diseases. Our goal is to deliver potential single treatment cures for patients in need. Our portfolio of product candidates is specifically designed to overcome the limitations of current generation cell and gene therapeutics. At Poseida we put people first. Our team is passionate about improving patients' lives through innovation. See what our team has to say about our culture: "My favorite part about Poseida is all the people that I get to work with. Everyone is so passionate about what we're doing here and there's so much camaraderie. It feels like one big enthusiastic family."

"My favorite part about working at Poseida is the amazing culture and working environment. Everybody is friendly, professional, collaborative, and has a remarkable can-do and positive attitude."

As we advance our compelling pipeline, there are endless opportunities for impact and growth. We encourage you to apply today!

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