Takeda Pharmaceuticals
Research Investigator
Takeda Pharmaceuticals, Boston, Massachusetts, us, 02298
Job Description
Pursuant to Section 20 C.F.R. 656.10, you are hereby notified that an application for Alien Employment Certification will be filed by Takeda Development Center Americas, Inc. for the following job opportunity:
JOB LOCATION:
Cambridge, MA POSITION:
Research Investigator POSITION DESCRIPTION:
Takeda Development Center Americas, Inc. is seeking a Research Investigator with the following duties: Lead efforts to design and develop analytical methods for the characterization of chimeric antigen receptor cells such as: immunophenotyping functionality and high throughput assays. Contribute strategic planning of activities, including prioritizing experiments and timelines effectively to meet project milestones and deliverables. Validation and Optimization: Revise and enhance the parameters within existing methodologies to align with the specifications of designed cells. Exercise independent judgement in selecting the most appropriate methods, coordinating efforts, and evaluating criteria for obtaining results. Analyze experimental data, interpret results, and independently draw conclusions to support product development, formulation, and processes. Summarize and present data within the department and occasionally to a broader audience. Contribute to technological transfer of experimental procedures/data internally and to external stakeholders as appropriate. Prepare comprehensive reports, protocols, and documentation for analytical methods, validation studies, and experimental findings, maintaining accurate records in compliance with regulatory standards. Up to 5% domestic travel required. REQUIREMENTS:
Master of Science degree in Chemical Engineering or related field plus 2 years of related experience. Prior experience must include: Performing high throughput immunophenotyping assay characterizing the drug product. Data analysis using FlowJo, MS Office, and GraphPad Prism to understand the phenotypic composition of the cell product. Immune cell handling, including cell isolation using Ficoll-Paque density gradient centrifugation and cell culture. Functional assays like proliferation and activation assays. Performing functional assays like ELISA to characterize cell therapy product. Routinely testing solubility and stability of compounds using UPLC, HPLC, and analyzing using Chromeleon. Characterizing in-process and drug products using Multi-color flow cytometry to determine cell composition. Preparing sensor substrate by selecting suitable material like silicon and functionalizing it to promote interaction with MIPs. Preparing Molecular Imprinted Polymer solution by dissolving the polymer in a suitable solvent. Full time. $96,600.00 - $165,600.00 per year. Competitive compensation and benefits. Qualified applicants can apply at
https://jobs.takeda.com . Please reference job
#R0138582 . EOE Any individual may provide documentary evidence bearing on this application, with information on available workers and information on wages and working conditions, to the Certifying Officer, U.S. Department of Labor, Employment and Training Administration, Office of Foreign Labor Certification, 200 Constitution Avenue, NW, Room N-5311, Washington, DC 20210. Locations
Boston, MA Worker Type
Employee Worker Sub-Type
Regular Time Type
Full time
#J-18808-Ljbffr
Cambridge, MA POSITION:
Research Investigator POSITION DESCRIPTION:
Takeda Development Center Americas, Inc. is seeking a Research Investigator with the following duties: Lead efforts to design and develop analytical methods for the characterization of chimeric antigen receptor cells such as: immunophenotyping functionality and high throughput assays. Contribute strategic planning of activities, including prioritizing experiments and timelines effectively to meet project milestones and deliverables. Validation and Optimization: Revise and enhance the parameters within existing methodologies to align with the specifications of designed cells. Exercise independent judgement in selecting the most appropriate methods, coordinating efforts, and evaluating criteria for obtaining results. Analyze experimental data, interpret results, and independently draw conclusions to support product development, formulation, and processes. Summarize and present data within the department and occasionally to a broader audience. Contribute to technological transfer of experimental procedures/data internally and to external stakeholders as appropriate. Prepare comprehensive reports, protocols, and documentation for analytical methods, validation studies, and experimental findings, maintaining accurate records in compliance with regulatory standards. Up to 5% domestic travel required. REQUIREMENTS:
Master of Science degree in Chemical Engineering or related field plus 2 years of related experience. Prior experience must include: Performing high throughput immunophenotyping assay characterizing the drug product. Data analysis using FlowJo, MS Office, and GraphPad Prism to understand the phenotypic composition of the cell product. Immune cell handling, including cell isolation using Ficoll-Paque density gradient centrifugation and cell culture. Functional assays like proliferation and activation assays. Performing functional assays like ELISA to characterize cell therapy product. Routinely testing solubility and stability of compounds using UPLC, HPLC, and analyzing using Chromeleon. Characterizing in-process and drug products using Multi-color flow cytometry to determine cell composition. Preparing sensor substrate by selecting suitable material like silicon and functionalizing it to promote interaction with MIPs. Preparing Molecular Imprinted Polymer solution by dissolving the polymer in a suitable solvent. Full time. $96,600.00 - $165,600.00 per year. Competitive compensation and benefits. Qualified applicants can apply at
https://jobs.takeda.com . Please reference job
#R0138582 . EOE Any individual may provide documentary evidence bearing on this application, with information on available workers and information on wages and working conditions, to the Certifying Officer, U.S. Department of Labor, Employment and Training Administration, Office of Foreign Labor Certification, 200 Constitution Avenue, NW, Room N-5311, Washington, DC 20210. Locations
Boston, MA Worker Type
Employee Worker Sub-Type
Regular Time Type
Full time
#J-18808-Ljbffr