Oligos Synthesis Lab Head

Site Name: USA - Massachusetts - Cambridge
Posted Date: Oct 31 2024

Are you driven by the challenge of designing and synthesizing novel oligonucleotide therapeutics? If so, we have the perfect opportunity for you.

As our Team Leader, Oligonucleotide Synthesis, you and your team will play a pivotal role in advancing GSK's pre-clinical pipeline through the synthesis, processing, and purification of therapeutic oligonucleotides. Your expertise will enable us to solve complex chemical challenges, pushing the boundaries of what's possible in oligonucleotide therapeutics.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Lead and Innovate: Establish, lead and develop the therapeutic oligonucleotide synthesis team, collaborating cross-functionally to advance our pre-clinical portfolio and technology platforms. Hire, manage, coach, and develop a high-performing team.
• Be the Expert: Serve as GSK's subject matter expert on discovery scale oligonucleotide synthesis. Keep abreast of industry advancements, regulatory requirements and competitor approaches in synthetic oligonucleotide chemistry.
• Communicate Impact: Provide regular updates and address challenges to stakeholders at all levels across GSK. Contribute to patents, publications, posters, and presentations, showcasing our scientific advancements.
• Standardize Excellence: Develop and maintain standard operating procedures (SOPs) for synthesis, processing, and purification to ensure high-quality, reproducible results.
• Foster Quality: Partner with the analytical chemistry team to ensure accountability and excellence in oligonucleotide and conjugate synthesis.
• Collaborate Externally: Support partnerships with external entities and manage relationships with CROs.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• BS/MS in Chemistry with 5+ years experience, or Ph.D. in Chemistry with 2+ years' experience, specializing in oligonucleotide synthesis and at least 2+ years in managing laboratory scientists.
• Experience in modern synthetic chemistry methods, particularly nucleosides, nucleotides, and oligonucleotide synthesis, purification, and analysis. Experience with oligonucleotide conjugation chemistries.
• Leadership experience, including training, developing, and managing talent and the ability to build, motivate, and inspire diverse high-performing teams.
• Organic chemistry experience of solving synthetic challenges in the field of therapeutic oligonucleotides.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Experience with oligonucleotide conjugation chemistries is desirable.
• Prior experience of establishing an oligonucleotide synthesis laboratory is a plus.
• Proven effective communication and negotiation skills suitable for a wide range of audiences, from laboratory analysts to senior management. Demonstrated effective organizational skills, including the ability to set, prioritize, and achieve research goals.
• Excellent scientific and analytical skills, with a demonstrable ability to multitask, prioritize, and drive projects to conclusion.
• A demonstrable understanding of RNA biology and contemporary oligonucleotide screening technologies.

#LI-GSK

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Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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