Principal Scientist, Protein Sciences

Treeline Biosciences was founded by an experienced team of biopharmaceutical scientists and executives committed to developing new medicines against compelling molecular targets in oncology. As a senior member of the Protein Sciences team, you will play an integral role supporting early-stage discovery programs by collaborating closely with a cross-functional team of scientists to impact small molecule drug discovery. In this role, you will report to the head of protein sciences and play a critical role to support early-stage drug discovery. Specifically, you will impact the target enabling strategy and design and implement gene-to-protein workflows to deliver high-quality protein for use in SAR enabling assays and structural biology efforts. As an integral part of project teams, you will drive lead discovery efforts by interpreting and integrating diverse data.ResponsibilitiesEstablish and implement strategies for enabling multiple protein targets.Design, express, and purify protein targets to support structural biology and small molecule drug discovery efforts.Manage and mentor PhD level Protein Scientists.Perform functional and biophysical characterization of proteins using novel and established technical methods.Interpret and integrate biochemical, biophysical and structural data to drive project decisions.Collaborate across lead discovery, medicine design, and medicinal chemistry teams to efficiently drive projects forward.Required QualificationsPhD in Biochemistry, Biophysics, Structural Biology or related discipline with 2-3 years of relevant postdoctoral training.7+ years of experience in biotech/pharma industry with a track record of producing difficult proteins for small molecule drug discovery projects and interpreting diverse data to drive SAR. Relevant industry experience is a requirement for this role.Experience and track record for managing PhD level scientists. Management experience is a requirement for this role.Strong candidates will have a track record working with challenging protein targets and/or multi-protein complexes to enable assay development, structural biology and hit finding.Proven hands-on experience with multiple expression platforms (e.g., bacteria, insect cell, mammalian cell) and proficiency with AKTA instrumentation and a broad range of standard and unique purification and protein QC techniques are required.Previous experience in small molecule drug discovery, specifically biochemical assay development and characterization of small molecule inhibitors and protein-ligand binding interactions.Strong candidates will have a track record integrating biochemical, biophysical and structural data to drive SAR and advance small molecule discovery from hit-finding to hit to lead stage.Experience in a wide array of biochemical assays, both enzymatic and binding, such as FP, TR-FRET, AlphaScreen, DSF, SPR, ITC is a plus.Candidates must possess excellent collaborative skills, demonstrate strong analytical and organizational skills, and work effectively under deadlines.This role requires excellent communication skills and the ability to report and present data to colleagues and senior leadership.

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