Researcher

The overall focus of the Charles lab is to decrease the global burden of mucosal and enteric infections affecting resource-poor and marginalized populations. More specifically, the work involves the application of high-throughput proteomic and genomic technologies to understand host-pathogen and immune responses during human infection by

V. cholerae

(the cause of cholera) and

Salmonella enterica

serovar Typhi and Paratyphi A (the primary cause of enteric fever) to identify immunogenic antigens or molecular signatures for vaccine and diagnostic assay development. Research in the lab utilizes human patient samples, murine models, and tumor cell lines for immunological, functional, and genome-scale assays including ELISAs, flow cytometry, and RNA-sequencing to address questions about protective immunity during human infection with

S. Typhi

or

V. cholerae

and develop diagnostic tools for resource-limited settings.Responsibilities include:Contribute directly to ongoing research projects.Lead scientific analysis, abstract submissions, and manuscript development for 1-2 projects.Travel to collaborative sites to support capacity building efforts.Supervise/Mentor trainees in the lab.Participate in collaborative grant-writing projects.The ideal candidate will be a highly motivated immunologist with a strong background in microbiology, molecular and/or cellular biology, and first-author publications in peer-reviewed journals. Experience in flow cytometry is required.Duties will be carried out in a typical laboratory environment. Occasional evening or weekend work may be required. Occasional travel to international research sites and scientific meetings may be necessary. The candidate may provide guidance to Research Technicians and students.Job qualifications:PhD in a life science field7+ years of experience in an academic, research, or related settingExperience in flow cytometry is requiredAdditional desired skills include:Gets Results/Takes InitiativeHigh personal work standards and sense of urgencyProblem-solving ability and initiative in ambiguous situationsAbility to work under pressure and in a collaborative environmentExcellent written and verbal communication skillsRespectful of cultural differences in communicationMassachusetts General Hospital is an Equal Opportunity Employer. Applications from protected veterans and individuals with disabilities are strongly encouraged.Primary Location

MGH Main CampusJob

MD/PHD/Fellows/PostDocsOrganization

Schedule

Full-timeStandard Hours: 40Shift

Day JobEmployee Status

RegularRecruiting Department: MGH Infectious Disease

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