University of Texas MD Anderson Cancer Center
Postdoc Fellow - Immunology (Dr. Curran's Lab)
University of Texas MD Anderson Cancer Center, Houston, Texas, United States, 77246
A postdoctoral position in basic and translational immune checkpoint biology and immunotherapy is available in the lab of Dr. Michael A. Curran at the University of Texas MD Anderson Cancer Center. Dr. Curran was the first to study and report the combination of CTLA-4 and PD-1 blockade which remains the most effective clinical immunotherapy. The Curran lab studies mechanisms of immune resistance in 'cold' cancers (prostate, pancreatic, glioblastoma), in particular, focused on tumor hypoxia and oxygen metabolism, as well as on novel approaches to modulation of the tumor myeloid stroma. Research in the lab spans basic T cell co-stimulatory biology, tumor microenvironment studies in murine models, and ongoing clinical trials and associated correlatives. The lab offers unique resources for research in mice and in man, as we have developed our own novel immune checkpoint antibodies and uniquely potent agonists of the Stimulator of Interferon Genes (STING) innate immune sensor.
LEARNING OBJECTIVESSuccessful candidates will lead a project to characterize how different DNA damage pathways engaged in tumors following radiotherapy act to block phagocytosis of dying tumor cells preventing anti-tumor immune priming, as well as how inhibition of either these DNA damage pathways or the downstream 'Don't Eat Me' signals can restore cancer immunogenicity following radiation therapy. The candidate will also participate/assist in manuscript writing for publication in scientific journals and/or presentations. They may also assist in grant writing. Assist with lab maintenance and preparation of shared reagents.
ELIGIBILITY REQUIREMENTSCandidates must have a recent Ph.D. degree in a related field along with lead-author publications, excellent communication skills, and the ability to work independently within a research team. Candidates who pursue an independent career path are highly preferred. Expertise in cancer immunology, murine tumor modeling, and/or tumor/immune metabolism is also desirable.
POSITION INFORMATIONMD Anderson follows the NIH stipend levels as outlined by the
Kirchstein - NRSA . This full-time trainee position will provide a salary between $56,484 to $68,604, dependent upon the years of postgraduate experience.
MD Anderson offers compensated trainees:
Paid medical benefits (zero premium) starting on first day for trainees who work 30 or more hours per weekGroup Dental, Vision, Life, AD&D and Disability coveragePaid Education Vacation and Sick LeavePaid institutional holidays, wellness leave, childcare leave and other paid leave programsTeachers Retirement System defined-benefit pension plan and two voluntary retirement plansEmployer paid life, AD&D and an illness-related reduced salary pay programHealth Savings Account and Dependent Care Reimbursement flexible spending accountsFertility benefitsState of Texas longevity payExtensive wellness, fitness, employee health programs and employee resource groups
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LEARNING OBJECTIVESSuccessful candidates will lead a project to characterize how different DNA damage pathways engaged in tumors following radiotherapy act to block phagocytosis of dying tumor cells preventing anti-tumor immune priming, as well as how inhibition of either these DNA damage pathways or the downstream 'Don't Eat Me' signals can restore cancer immunogenicity following radiation therapy. The candidate will also participate/assist in manuscript writing for publication in scientific journals and/or presentations. They may also assist in grant writing. Assist with lab maintenance and preparation of shared reagents.
ELIGIBILITY REQUIREMENTSCandidates must have a recent Ph.D. degree in a related field along with lead-author publications, excellent communication skills, and the ability to work independently within a research team. Candidates who pursue an independent career path are highly preferred. Expertise in cancer immunology, murine tumor modeling, and/or tumor/immune metabolism is also desirable.
POSITION INFORMATIONMD Anderson follows the NIH stipend levels as outlined by the
Kirchstein - NRSA . This full-time trainee position will provide a salary between $56,484 to $68,604, dependent upon the years of postgraduate experience.
MD Anderson offers compensated trainees:
Paid medical benefits (zero premium) starting on first day for trainees who work 30 or more hours per weekGroup Dental, Vision, Life, AD&D and Disability coveragePaid Education Vacation and Sick LeavePaid institutional holidays, wellness leave, childcare leave and other paid leave programsTeachers Retirement System defined-benefit pension plan and two voluntary retirement plansEmployer paid life, AD&D and an illness-related reduced salary pay programHealth Savings Account and Dependent Care Reimbursement flexible spending accountsFertility benefitsState of Texas longevity payExtensive wellness, fitness, employee health programs and employee resource groups
#J-18808-Ljbffr