Scientist I, Functional Genomics

Light Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading academics Brian Liau (Harvard), Ben Cravatt (Scripps) and Nathanael Gray (Stanford) with initial financial backing from Versant Ventures and Mubadala Capital.Light Horse Therapeutics is seeking a talented, motivated, and creative scientist to join the Functional Genomics Group. Reporting to the Senior Director of Functional Genomics, the candidate will contribute to the design, execution, and analysis of CRISPR-based gene editing screens to study novel oncology targets. They will also perform mechanistic experiments to characterize these targets and the impact of various mutations on their function.Job Description:Design and execute CRISPR-based mutagenesis screens using state-of-the-art technologiesDesign, execute and analyze target and site validation studies in disease-relevant preclinical modelsDevelop new CRISPR screening formats and new cell-based assaysStay abreast of the literature and interact with academic expertsWork closely with computational biology for the design and analysis of CRISPR screensPosition mostly requires benchwork responsibilitiesPresent results regularly at team meetingsPerform diligent and timely note-keeping and work process trackingCommunicate science and strategy effectively in internal meetings and prepare written reports of data and literature analysesRequired Qualifications:PhD in a biological scienceProficiency in mammalian cell line culture, especially large-scale projectsProficiency in standard molecular biology techniques, including RNA and DNA preparation, analysis of proteins by immunoprecipitation and western blotting, mammalian cell line transfectionTrack record of being able to work independently and to create new workflowsExcellent technical laboratory skillsExcellent written and oral communication skillsAttention to details in documenting, executing, and analyzing experimentsFlexibility and eagerness to tackle new tasks and challenges, and meet aggressive timelinesAbility to work closely with team membersPreferred QualificationsExperience with large scale functional genomics experiments, including CRISPR-Cas9 mutagenesis screensExperience with lentivirus production, infection, and selectionExperience constructing next generation sequencing librariesExperience with state-of-the-art instrumentation including, plate readers, flow cytometers, incucyte, epifluorescence microscopesFamiliarity with electronic notebook platforms such as BenchlingsWe offer a competitive total compensation package, as well as working in a supportive team environment. The anticipated salary range for candidates who will work in

San Diego, CA

is

$98,000

to

$140,000 . The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc.

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