The University of Texas MD Anderson Cancer Center
Sr. Scientist, Chemistry
The University of Texas MD Anderson Cancer Center, Indianapolis, Iowa, United States,
Job Title: Sr. Scientist, Chemistry
Job Number:
35227
Location:
Indianapolis,IA
Job Description
Responsibilities
Position SummaryAs a Senior Scientist, you will be part of a Chemistry group that drives the design, synthesis, and characterization of chemical leads and drug candidates supporting our drug discovery portfolio. The role requires creative thinking and the ability to efficiently bring ideas into practice. The projects may require experience working with peptides and proteins, chemical synthesis, purification (HPLC, IEC, silica gel, etc.), analytical characterization (LCMS, NMR, SDS-page, etc.), and biophysical analysis (SEC, DSF, DLS, AUC, etc.). This position involves working collaboratively within a cross-functional team and offers an exciting opportunity to be a part of a fast-paced research environment, pioneering the development of a novel therapeutics.
Key Responsibilities
Drug design and synthesis:
Design and synthesize compounds with the potential for therapeutic applications in metabolic diseases.
Plan and implement various modification schemas to optimize peptides and proteins for future clinical application.
Purification of the drug candidates and intermediates using techniques such as HPLC, IEC, SEC and silica gel flash chromatography.
Compound characterization:
Utilize analytical techniques, such as
LCMS, NMR, SDS-page, etc.,
for the characterization of synthesized compounds.
Ensure the purity, identity and biophysical properties of compounds meet the required standards for optimal therapeutic application.
Data Analysis and Interpretation:
Perform data analysis using appropriate statistical and computational tools.
Interpret and present results to multidisciplinary project teams, contributing to decision-making processes in drug discovery programs.
Maintain detailed and organized laboratory records, documenting experimental procedures, observations, and results.
Collaboration and Communication:
Work closely with medicinal chemists, biologists, pharmacologists, and other research personnel to support the progression of drug candidates.
Communicate development progress, results, and challenges to internal and external stakeholders through written reports and oral presentations.
Display professional ethics in using shared equipment in the incubator space and in the interactions with other personnel.
Compliance and Safety:
Ensure compliance with all relevant regulatory requirements, guidelines, and laboratory safety protocols.
Participate in laboratory inspections and audits from site and city officials as needed.
Required Skills
QualificationsEducation:
Ph.D. in Medicinal Chemistry, Organic Chemistry, or a related field.
Master’s degree with 4+ years of relevant experience.
Bachelor’s degree with 8+ years of relevant experience.
Experience:
Relevant commercial experience is preferred but not a necessity.
Technical Skills:
Expertise in the chemistry of peptides and proteins.
Proficiency in relevant purification and analytical techniques.
Demonstrated experience in any of the following: organic chemical synthesis, peptide and protein modification, biophysical techniques, and drug formulation.
Strong data analysis skills, including familiarity with software tools like GraphPad Prism, Excel, and relevant statistical software.
Experience with electronic inventory systems (Quartzy) and maintaining an electronic lab notebook (Benchling).
Excellent command of Microsoft Suite.
Soft Skills:
Self-starter capable of employment in a high energy environment.
Excellent problem-solving skills and attention to detail.
Strong organizational and project management abilities.
Effective communication and interpersonal skills for collaborative work.
Preferred Qualifications:
Knowledge of drug discovery and development processes.
Experience with laboratory automation and liquid handling systems.
Experience in a pharmaceutical or biotechnology commercial setting.
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Job Number:
35227
Location:
Indianapolis,IA
Job Description
Responsibilities
Position SummaryAs a Senior Scientist, you will be part of a Chemistry group that drives the design, synthesis, and characterization of chemical leads and drug candidates supporting our drug discovery portfolio. The role requires creative thinking and the ability to efficiently bring ideas into practice. The projects may require experience working with peptides and proteins, chemical synthesis, purification (HPLC, IEC, silica gel, etc.), analytical characterization (LCMS, NMR, SDS-page, etc.), and biophysical analysis (SEC, DSF, DLS, AUC, etc.). This position involves working collaboratively within a cross-functional team and offers an exciting opportunity to be a part of a fast-paced research environment, pioneering the development of a novel therapeutics.
Key Responsibilities
Drug design and synthesis:
Design and synthesize compounds with the potential for therapeutic applications in metabolic diseases.
Plan and implement various modification schemas to optimize peptides and proteins for future clinical application.
Purification of the drug candidates and intermediates using techniques such as HPLC, IEC, SEC and silica gel flash chromatography.
Compound characterization:
Utilize analytical techniques, such as
LCMS, NMR, SDS-page, etc.,
for the characterization of synthesized compounds.
Ensure the purity, identity and biophysical properties of compounds meet the required standards for optimal therapeutic application.
Data Analysis and Interpretation:
Perform data analysis using appropriate statistical and computational tools.
Interpret and present results to multidisciplinary project teams, contributing to decision-making processes in drug discovery programs.
Maintain detailed and organized laboratory records, documenting experimental procedures, observations, and results.
Collaboration and Communication:
Work closely with medicinal chemists, biologists, pharmacologists, and other research personnel to support the progression of drug candidates.
Communicate development progress, results, and challenges to internal and external stakeholders through written reports and oral presentations.
Display professional ethics in using shared equipment in the incubator space and in the interactions with other personnel.
Compliance and Safety:
Ensure compliance with all relevant regulatory requirements, guidelines, and laboratory safety protocols.
Participate in laboratory inspections and audits from site and city officials as needed.
Required Skills
QualificationsEducation:
Ph.D. in Medicinal Chemistry, Organic Chemistry, or a related field.
Master’s degree with 4+ years of relevant experience.
Bachelor’s degree with 8+ years of relevant experience.
Experience:
Relevant commercial experience is preferred but not a necessity.
Technical Skills:
Expertise in the chemistry of peptides and proteins.
Proficiency in relevant purification and analytical techniques.
Demonstrated experience in any of the following: organic chemical synthesis, peptide and protein modification, biophysical techniques, and drug formulation.
Strong data analysis skills, including familiarity with software tools like GraphPad Prism, Excel, and relevant statistical software.
Experience with electronic inventory systems (Quartzy) and maintaining an electronic lab notebook (Benchling).
Excellent command of Microsoft Suite.
Soft Skills:
Self-starter capable of employment in a high energy environment.
Excellent problem-solving skills and attention to detail.
Strong organizational and project management abilities.
Effective communication and interpersonal skills for collaborative work.
Preferred Qualifications:
Knowledge of drug discovery and development processes.
Experience with laboratory automation and liquid handling systems.
Experience in a pharmaceutical or biotechnology commercial setting.
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