The University of Texas MD Anderson Cancer Center
Sr. Scientist, Chemistry
The University of Texas MD Anderson Cancer Center, Indianapolis, Indiana, us, 46262
Job Title: Sr. Scientist, Chemistry
Job Number:
83465
Location:
Indianapolis,US
Job Description
ResponsibilitiesPosition Summary
As a Senior Scientist, you will be part of a Chemistry group that drives the
design, synthesis, and characterization of chemical leads and drug candidates
supporting our drug discovery portfolio. The role requires creative thinking
and the ability to efficiently bring ideas into practice. The projects may
require experience working with peptides and proteins, chemical synthesis,
purification (HPLC, IEC, silica gel, etc.), analytical characterization (LCMS,
NMR, SDS-page, etc.), and biophysical analysis (SEC, DSF, DLS, AUC, etc.). This
position involves working collaboratively within a cross-functional team and
offers an exciting opportunity to be a part of a fast-paced research
environment, pioneering the development of a novel therapeutics.
Key Responsibilities
* Drug design and synthesis:
* Design and synthesize compounds with the potential for therapeutic
applications in metabolic diseases.
* Plan and implement various modification schemas to optimize peptides and
proteins for future clinical application.
* Purification of the drug candidates and intermediates using techniques such
as HPLC, IEC, SEC and silica gel flash chromatography.
* Compound characterization:
* Utilize analytical techniques, such asLCMS, NMR, SDS-page, etc., for the
characterization of synthesized compounds.
* Ensure the purity, identity and biophysical properties of compounds meet
the required standards for optimal therapeutic application.
* Data Analysis and Interpretation:
* Perform data analysis using appropriate statistical and computational tools.
* Interpret and present results to multidisciplinary project teams,
contributing to decision-making processes in drug discovery programs.
* Maintain detailed and organized laboratory records, documenting
experimental procedures, observations, and results.
* Collaboration and Communication:
* Work closely with medicinal chemists, biologists, pharmacologists, and
other research personnel to support the progression of drug candidates.
* Communicate development progress, results, and challenges to internal and
external stakeholders through written reports and oral presentations.
* Display professional ethics in using shared equipment in the incubator
space and in the interactions with other personnel.
* Compliance and Safety:
* Ensure compliance with all relevant regulatory requirements, guidelines,
and laboratory safety protocols.
* Participate in laboratory inspections and audits from site and city
officials as needed.
Required SkillsQualifications
Education:
* Ph.D. in Medicinal Chemistry, Organic Chemistry, or a related field.
* Master’s degree with 4+ years of relevant experience.
* Bachelor’s degree with 8+ years of relevant experience. Experience:
* Relevant commercial experience is preferred but not a necessity. Technical Skills:
* Expertise in the chemistry of peptides and proteins.
* Proficiency in relevant purification and analytical techniques.
* Demonstrated experience in any of the following: organic chemical
synthesis, peptide and protein modification, biophysical techniques, and drug
formulation.
* Strong data analysis skills, including familiarity with software tools like
GraphPad Prism, Excel, and relevant statistical software.
* Experience with electronic inventory systems (Quartzy) and maintaining an
electronic lab notebook (Benchling).
* Excellent command of Microsoft Suite. Soft Skills:
* Self-starter capable of employment in a high energy environment.
* Excellent problem-solving skills and attention to detail.
* Strong organizational and project management abilities.
* Effective communication and interpersonal skills for collaborative work. Preferred Qualifications:
* Knowledge of drug discovery and development processes.
* Experience with laboratory automation and liquid handling systems.
* Experience in a pharmaceutical or biotechnology commercial setting.
Application Deadline:
2024-09-23
#J-18808-Ljbffr
Job Number:
83465
Location:
Indianapolis,US
Job Description
ResponsibilitiesPosition Summary
As a Senior Scientist, you will be part of a Chemistry group that drives the
design, synthesis, and characterization of chemical leads and drug candidates
supporting our drug discovery portfolio. The role requires creative thinking
and the ability to efficiently bring ideas into practice. The projects may
require experience working with peptides and proteins, chemical synthesis,
purification (HPLC, IEC, silica gel, etc.), analytical characterization (LCMS,
NMR, SDS-page, etc.), and biophysical analysis (SEC, DSF, DLS, AUC, etc.). This
position involves working collaboratively within a cross-functional team and
offers an exciting opportunity to be a part of a fast-paced research
environment, pioneering the development of a novel therapeutics.
Key Responsibilities
* Drug design and synthesis:
* Design and synthesize compounds with the potential for therapeutic
applications in metabolic diseases.
* Plan and implement various modification schemas to optimize peptides and
proteins for future clinical application.
* Purification of the drug candidates and intermediates using techniques such
as HPLC, IEC, SEC and silica gel flash chromatography.
* Compound characterization:
* Utilize analytical techniques, such asLCMS, NMR, SDS-page, etc., for the
characterization of synthesized compounds.
* Ensure the purity, identity and biophysical properties of compounds meet
the required standards for optimal therapeutic application.
* Data Analysis and Interpretation:
* Perform data analysis using appropriate statistical and computational tools.
* Interpret and present results to multidisciplinary project teams,
contributing to decision-making processes in drug discovery programs.
* Maintain detailed and organized laboratory records, documenting
experimental procedures, observations, and results.
* Collaboration and Communication:
* Work closely with medicinal chemists, biologists, pharmacologists, and
other research personnel to support the progression of drug candidates.
* Communicate development progress, results, and challenges to internal and
external stakeholders through written reports and oral presentations.
* Display professional ethics in using shared equipment in the incubator
space and in the interactions with other personnel.
* Compliance and Safety:
* Ensure compliance with all relevant regulatory requirements, guidelines,
and laboratory safety protocols.
* Participate in laboratory inspections and audits from site and city
officials as needed.
Required SkillsQualifications
Education:
* Ph.D. in Medicinal Chemistry, Organic Chemistry, or a related field.
* Master’s degree with 4+ years of relevant experience.
* Bachelor’s degree with 8+ years of relevant experience. Experience:
* Relevant commercial experience is preferred but not a necessity. Technical Skills:
* Expertise in the chemistry of peptides and proteins.
* Proficiency in relevant purification and analytical techniques.
* Demonstrated experience in any of the following: organic chemical
synthesis, peptide and protein modification, biophysical techniques, and drug
formulation.
* Strong data analysis skills, including familiarity with software tools like
GraphPad Prism, Excel, and relevant statistical software.
* Experience with electronic inventory systems (Quartzy) and maintaining an
electronic lab notebook (Benchling).
* Excellent command of Microsoft Suite. Soft Skills:
* Self-starter capable of employment in a high energy environment.
* Excellent problem-solving skills and attention to detail.
* Strong organizational and project management abilities.
* Effective communication and interpersonal skills for collaborative work. Preferred Qualifications:
* Knowledge of drug discovery and development processes.
* Experience with laboratory automation and liquid handling systems.
* Experience in a pharmaceutical or biotechnology commercial setting.
Application Deadline:
2024-09-23
#J-18808-Ljbffr