System One
Associate Scientist
System One, Seattle, Washington, us, 98127
Job Title : Associate Scientist
Location : Seattle, WA
Pay Range:
$57 – 67.70/hrType:
Contract, Potential for extension or conversion to permanent
OverviewSeeking a highly motivated Associate, or Sr. Associate, Scientist to work in a fast-paced PD environment applying rigorous scientific principles towards developing a platform process for producing mRNA. As a part of the Gene Delivery and Editing Process Development (GDEPD) organization, the ideal Associate will possess sufficient experience in the downstream process development of biological molecules, with a high preference for any experience with developing processes with nucleic acids. The Associate will also gain familiarity with mRNA analytical methods and their interpretation in the context of mRNA attributes and function in gene editing applications.
A successful Associate will directly employ purification principles and biochemistry techniques to develop our next-generation gene edited therapies. In this capacity, the Associate will produce, purify, and characterize mRNA molecules to enable robust ex vivo studies. This candidate will use recombinant enzymes to produce and functionalize mRNA, AKTA systems to purify mRNA via affinity and other chromatography methods, TFF to further purify and formulate mRNA, as well as use HPLCs and other biochemical analytical techniques for characterization. An outstanding candidate will be driven by a desire to create, optimize, and define processes with speed in a collaborative environment.
Responsibilities
Material generation of purified mRNA
Execute and troubleshoot IVT and downstream process development experiments
Manage the flow of samples and data with various downstream users of mRNA
Assist in the design of experiments and interpretation of data
Actively participate and support lab maintenance and continuous improvement initiatives
Maintain accurate and detailed laboratory notebook and documentation
Summarize and present data in group meetings and contribute to group discussions
Author technical reports, study memos, and protocols
RequirementsBasic Qualifications:
STEM degree with 2+ years of relevant industry experience; title/compensation will be commensurate with education, experience, and skillset
Hands-on experience with the downstream purification of biological molecules (AKTA, chromatography, TFF, viral filtration, etc.)
Experience with molecular cloning, PAGE, and agarose gels
Experience working with, storing, and analyzing purified nucleic acids
Independently motivated with the ability to work in teams
Ability to communicate clearly and concisely through oral presentation and technical writing
Ability to leverage literature, internal and external resources to solve problems and develop new technologies
Preferred Qualifications:
Degree in biological or chemical engineering, biochemistry, or bio-related field
Experience with JMP for DoE design and analysis
Experience with IVT of mRNA, including successful transfer for GMP manufacturing
Experience with recombinant nucleic acid processing enzymes
Experience with interpreting qPCR, HPLC, NGS, and mass spec data sets
Experience interacting and collaborating with vendors
Additional Requirements:
Lab w/o blood & animal
Position Handles Hazardous Materials
BenefitsSystem One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
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Location : Seattle, WA
Pay Range:
$57 – 67.70/hrType:
Contract, Potential for extension or conversion to permanent
OverviewSeeking a highly motivated Associate, or Sr. Associate, Scientist to work in a fast-paced PD environment applying rigorous scientific principles towards developing a platform process for producing mRNA. As a part of the Gene Delivery and Editing Process Development (GDEPD) organization, the ideal Associate will possess sufficient experience in the downstream process development of biological molecules, with a high preference for any experience with developing processes with nucleic acids. The Associate will also gain familiarity with mRNA analytical methods and their interpretation in the context of mRNA attributes and function in gene editing applications.
A successful Associate will directly employ purification principles and biochemistry techniques to develop our next-generation gene edited therapies. In this capacity, the Associate will produce, purify, and characterize mRNA molecules to enable robust ex vivo studies. This candidate will use recombinant enzymes to produce and functionalize mRNA, AKTA systems to purify mRNA via affinity and other chromatography methods, TFF to further purify and formulate mRNA, as well as use HPLCs and other biochemical analytical techniques for characterization. An outstanding candidate will be driven by a desire to create, optimize, and define processes with speed in a collaborative environment.
Responsibilities
Material generation of purified mRNA
Execute and troubleshoot IVT and downstream process development experiments
Manage the flow of samples and data with various downstream users of mRNA
Assist in the design of experiments and interpretation of data
Actively participate and support lab maintenance and continuous improvement initiatives
Maintain accurate and detailed laboratory notebook and documentation
Summarize and present data in group meetings and contribute to group discussions
Author technical reports, study memos, and protocols
RequirementsBasic Qualifications:
STEM degree with 2+ years of relevant industry experience; title/compensation will be commensurate with education, experience, and skillset
Hands-on experience with the downstream purification of biological molecules (AKTA, chromatography, TFF, viral filtration, etc.)
Experience with molecular cloning, PAGE, and agarose gels
Experience working with, storing, and analyzing purified nucleic acids
Independently motivated with the ability to work in teams
Ability to communicate clearly and concisely through oral presentation and technical writing
Ability to leverage literature, internal and external resources to solve problems and develop new technologies
Preferred Qualifications:
Degree in biological or chemical engineering, biochemistry, or bio-related field
Experience with JMP for DoE design and analysis
Experience with IVT of mRNA, including successful transfer for GMP manufacturing
Experience with recombinant nucleic acid processing enzymes
Experience with interpreting qPCR, HPLC, NGS, and mass spec data sets
Experience interacting and collaborating with vendors
Additional Requirements:
Lab w/o blood & animal
Position Handles Hazardous Materials
BenefitsSystem One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
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