UHBW Trust
Staff Research Associate - Surgical Oncology Research
UHBW Trust, San Francisco, California, United States, 94199
SurgeryFull Time78138BRJob Summary
The Staff Research Associate (SRA) position will be involved in research with Dr. Robert Warren, the principal investigator of the Surgical Oncology Research Lab. The SRA will conduct research related to growth of organoids as models to study targeted therapeutics against cancers of the gastrointestinal system in humans, and will be expected to pick up specimens of gastrointestinal tumors directly from surgeries. Under the direction of Dr. Warren, the SRA will take the specimen to the laboratory and dissociate the tumor into cells using enzymes. The cells will be placed into low adherence tissue culture plates in which they will aggregate to form clusters that are called organoids. The organoids will next be transferred into multiwell culture plates and there will be exposed to drugs. The drugs will be dispensed into the multiwell plates using a robotic drug dispenser, which the SRA will learn to use. The ability of any drug to affect the viability of the organoid will be assayed microscopically and by using a kit that assays the ATP content of the organoids: viable organoids can produce ATP whereas dead organoids cannot.The SRA will be taught to use the microscope and the software associated with it to determine the size and viability of the organoids and likewise the use of the ATP assay kit. In addition, the SRA will be taught classical, sterile tissue culture techniques in order to permit the growth and culture of tumor cells that are maintained in long-term culture. These cultured cells will also be tested for their responsiveness to drugs when grown in the absence or presence of other cell types such as fibroblasts and immune cells.This position will also be responsible for ordering reagents/supplies, maintaining laboratory records, maintaining lab safety, handling equipment repair orders and maintenance.Note: This position requires a physical/health screening.Required Qualifications
BA/BS in a related science and knowledge of, or experience with, the basic techniques or methods required by the position; and/or an equivalent combination of education and experience.Preferred Qualifications
BA or BS in Biology, Molecular Biology or Biochemistry.Prior laboratory experience in a group studying molecular and cellular biology. Experience in cell signaling preferred.Familiarity with Western blotting, cell culture, nucleic acid extraction from cells and tissues and an objective indication of competence, such as publications. The new SRA will be trained to become expert in all of these methods by Dr. Warren.Interactive and collegial.Capacity to learn new procedures quickly.About UCSF
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world’s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.Pride Values
UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence – also known as our PRIDE values.In addition to our PRIDE values, UCSF is committed to equity – both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available at diversity.ucsf.edu.Equal Employment Opportunity
The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.Organization
CampusJob Code and Payroll Title
009613 SRA 1Job Category
Research and ScientificBargaining Unit
University Professional Technical Employees – Research Support Professionals Unit (UPTE-RX)Employee Class
CareerPercentage
100%Location
Mount Zion (SF)Shift
DaysShift Length
8 HoursAdditional Shift Details
Monday - Friday, 8:00am - 5:00pm
#J-18808-Ljbffr
The Staff Research Associate (SRA) position will be involved in research with Dr. Robert Warren, the principal investigator of the Surgical Oncology Research Lab. The SRA will conduct research related to growth of organoids as models to study targeted therapeutics against cancers of the gastrointestinal system in humans, and will be expected to pick up specimens of gastrointestinal tumors directly from surgeries. Under the direction of Dr. Warren, the SRA will take the specimen to the laboratory and dissociate the tumor into cells using enzymes. The cells will be placed into low adherence tissue culture plates in which they will aggregate to form clusters that are called organoids. The organoids will next be transferred into multiwell culture plates and there will be exposed to drugs. The drugs will be dispensed into the multiwell plates using a robotic drug dispenser, which the SRA will learn to use. The ability of any drug to affect the viability of the organoid will be assayed microscopically and by using a kit that assays the ATP content of the organoids: viable organoids can produce ATP whereas dead organoids cannot.The SRA will be taught to use the microscope and the software associated with it to determine the size and viability of the organoids and likewise the use of the ATP assay kit. In addition, the SRA will be taught classical, sterile tissue culture techniques in order to permit the growth and culture of tumor cells that are maintained in long-term culture. These cultured cells will also be tested for their responsiveness to drugs when grown in the absence or presence of other cell types such as fibroblasts and immune cells.This position will also be responsible for ordering reagents/supplies, maintaining laboratory records, maintaining lab safety, handling equipment repair orders and maintenance.Note: This position requires a physical/health screening.Required Qualifications
BA/BS in a related science and knowledge of, or experience with, the basic techniques or methods required by the position; and/or an equivalent combination of education and experience.Preferred Qualifications
BA or BS in Biology, Molecular Biology or Biochemistry.Prior laboratory experience in a group studying molecular and cellular biology. Experience in cell signaling preferred.Familiarity with Western blotting, cell culture, nucleic acid extraction from cells and tissues and an objective indication of competence, such as publications. The new SRA will be trained to become expert in all of these methods by Dr. Warren.Interactive and collegial.Capacity to learn new procedures quickly.About UCSF
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world’s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.Pride Values
UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence – also known as our PRIDE values.In addition to our PRIDE values, UCSF is committed to equity – both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available at diversity.ucsf.edu.Equal Employment Opportunity
The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.Organization
CampusJob Code and Payroll Title
009613 SRA 1Job Category
Research and ScientificBargaining Unit
University Professional Technical Employees – Research Support Professionals Unit (UPTE-RX)Employee Class
CareerPercentage
100%Location
Mount Zion (SF)Shift
DaysShift Length
8 HoursAdditional Shift Details
Monday - Friday, 8:00am - 5:00pm
#J-18808-Ljbffr