Rush University Medical Center
Research Scientist II -HCMG - Alzheimer Center - Full-time
Rush University Medical Center, Chicago, Illinois, United States, 60290
Job Description
Location:
Chicago, IL
Hospital:
RUSH University Medical Center
Department:
Rush Alzheimers Dis Ctr-ResFac
Work Type:
Full Time (Total FTE between 0.9 and 1.0)
Shift:
Shift 1
Work Schedule:
8 Hr (9:00:00 AM - 5:00:00 PM)
Summary:
The Staff Research Scientist will design and perform complex scientific research experiments. This person will lead research efforts on human iPSC-based disease modeling or/and CRISPR gene perturbations. The job will perform experiments, analyze data, compile results, and monitor quality control processes to ensure integrity of research. The position will utilize knowledge of molecular biology, neurobiology, cell biology, human genomics, and stem cell biology. This person will troubleshoot and evaluate data, and prepare manuscripts based on experimental results. The work requires the application of highly specialized knowledge of brain development and human genetic/epigenetic regulations. Some of the related techniques that will be applied in the research to be conducted will include human iPSC cultures, neural differentiation, brain organoid cultures, high-content imaging, molecular biology, viral packaging, CRISPR gene perturbations and data analysis. Exemplifies the Rush mission, vision and values and acts in accordance with Rush policies and procedures.
Responsibilities:
Mentor technicians and graduate students
Generate multi-cellular 2D and 3D culture models to incorporate different cell types
Develop cellular, molecular, and functional assays to examine AD phenotype in the dish
Conduct gene perturbation experiments to test AD candidate genes
Collect and analyze multi-module data, including imaging, FACS, qRT-PCR, targeting sequencing etc.
Coordinate other team members to successfully execute the research plan
Prepare and/or publish scientific papers and manuscripts
Contribute to grant writing
Communicate with other RADC teams on related projects.
Plan and conduct statistical analysis of data
Prepare abstracts and meeting materials to present (slides, posters) within scientific group
Plan meetings (such as investigator meetings and other scientific/operational meetings)
Design and execute complex research procedures.
Develop and perform routine and complex protocols for research programs.
Assist in developing, implementing, and monitoring quality activities.
Collaborate with principal investigators in determining study design and performing statistical analyses.
Perform and develop routine and complex computational and database methods for implementation.
Participate in meetings with principal investigator and research staff and evaluate/interpret the validity of data, develop methodologies, evaluate lab procedures.
May oversee the work of laboratory personnel including training and development as well as daily work direction/delegation/prioritizing.
Required Job Qualifications:
Ph.D. with 3 years expertise in Neuroscience, Cell biology, Developmental biology, Stem cell biology, molecular biology, or related field or a Master’s degree with 6 years of experience.
Excellent skills and experience in human iPSC cultures, neural differentiation, and brain organoid cultures.
Excellent skills and experience in assay development and high-content imaging.
Excellent skills and experience in molecular biology and CRISPR gene perturbations
Excellent project planning, organization, and problem-solving skills.
Excellent communication and interpersonal skills
Proven ability to work independently and in collaborative team environments.
Ability to work for 8 hours daily in the lab.
Disclaimer:
The above is intended to describe the general content of and requirements for the performance of this job. It is not to be construed as an exhaustive statement of duties, responsibilities, or requirements.
Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.
Position:
Research Scientist II -HCMG - Alzheimer Center - Full-time
Location:
US:IL:Chicago
Req ID:
2666
#J-18808-Ljbffr
Location:
Chicago, IL
Hospital:
RUSH University Medical Center
Department:
Rush Alzheimers Dis Ctr-ResFac
Work Type:
Full Time (Total FTE between 0.9 and 1.0)
Shift:
Shift 1
Work Schedule:
8 Hr (9:00:00 AM - 5:00:00 PM)
Summary:
The Staff Research Scientist will design and perform complex scientific research experiments. This person will lead research efforts on human iPSC-based disease modeling or/and CRISPR gene perturbations. The job will perform experiments, analyze data, compile results, and monitor quality control processes to ensure integrity of research. The position will utilize knowledge of molecular biology, neurobiology, cell biology, human genomics, and stem cell biology. This person will troubleshoot and evaluate data, and prepare manuscripts based on experimental results. The work requires the application of highly specialized knowledge of brain development and human genetic/epigenetic regulations. Some of the related techniques that will be applied in the research to be conducted will include human iPSC cultures, neural differentiation, brain organoid cultures, high-content imaging, molecular biology, viral packaging, CRISPR gene perturbations and data analysis. Exemplifies the Rush mission, vision and values and acts in accordance with Rush policies and procedures.
Responsibilities:
Mentor technicians and graduate students
Generate multi-cellular 2D and 3D culture models to incorporate different cell types
Develop cellular, molecular, and functional assays to examine AD phenotype in the dish
Conduct gene perturbation experiments to test AD candidate genes
Collect and analyze multi-module data, including imaging, FACS, qRT-PCR, targeting sequencing etc.
Coordinate other team members to successfully execute the research plan
Prepare and/or publish scientific papers and manuscripts
Contribute to grant writing
Communicate with other RADC teams on related projects.
Plan and conduct statistical analysis of data
Prepare abstracts and meeting materials to present (slides, posters) within scientific group
Plan meetings (such as investigator meetings and other scientific/operational meetings)
Design and execute complex research procedures.
Develop and perform routine and complex protocols for research programs.
Assist in developing, implementing, and monitoring quality activities.
Collaborate with principal investigators in determining study design and performing statistical analyses.
Perform and develop routine and complex computational and database methods for implementation.
Participate in meetings with principal investigator and research staff and evaluate/interpret the validity of data, develop methodologies, evaluate lab procedures.
May oversee the work of laboratory personnel including training and development as well as daily work direction/delegation/prioritizing.
Required Job Qualifications:
Ph.D. with 3 years expertise in Neuroscience, Cell biology, Developmental biology, Stem cell biology, molecular biology, or related field or a Master’s degree with 6 years of experience.
Excellent skills and experience in human iPSC cultures, neural differentiation, and brain organoid cultures.
Excellent skills and experience in assay development and high-content imaging.
Excellent skills and experience in molecular biology and CRISPR gene perturbations
Excellent project planning, organization, and problem-solving skills.
Excellent communication and interpersonal skills
Proven ability to work independently and in collaborative team environments.
Ability to work for 8 hours daily in the lab.
Disclaimer:
The above is intended to describe the general content of and requirements for the performance of this job. It is not to be construed as an exhaustive statement of duties, responsibilities, or requirements.
Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.
Position:
Research Scientist II -HCMG - Alzheimer Center - Full-time
Location:
US:IL:Chicago
Req ID:
2666
#J-18808-Ljbffr