Entos
Director/Sr. Director GPCR Drug Discovery Biologist
Entos, San Diego, California, United States, 92189
JOB SUMMARYWe are seeking a highly motivated and experienced biologist to lead GPCR drug discovery efforts at Iambic Therapeutics, which includes leading in vivo and in vitro pharmacology efforts. The job title/level will take into consideration the skills and experience of the candidate that is selected. This role is based at the San Diego headquarters.
The successful candidate will have a proven track record driving GPCR drug discovery programs from target validation through lead optimization.
This person will join the biology team and advance our core mission of accelerating drug discovery programs leveraging AI. The candidate will work closely with a cross-functional team that integrates machine learning, medicinal chemistry, analytical technology and biology to revolutionize small-molecule therapeutics design and discovery.RESPONSIBILITIESHelp guide strategy around GPCR drug discovery efforts, mentor and inspire a team of in vitro pharmacology and lead generation scientists to achieve data-driven outcomes efficiently, leveraging both internal and external resourcesPartner with senior leadership to communicate vision and innovation in drug discovery in alignment with company goals.Lead GPCR in vivo and in vitro pharmacology effortsLead and manage internal GPCR assay development (biochemistry and cell biology)Drive GPCR drug discovery programsLead pharmacology efforts to support the advancement of GPCR drug discovery projects from hit ID through development candidate selectionIndependently manage CRO scientists in the design, development, and implementation of in vitro/in vivo assays for the advancement of GPCR projectsGuide KOL interaction and research strategy for exploratory and early stage GPCR drug discovery effortsLead biology function within a multi-disciplinary teams/project which includes setting priorities, effectively communicating with, coordinating efforts and motivating team members.REQUIREMENTSPhD in biochemistry
, pharmacology
or related field with a high level of expertise in GPCR pharmacologyAt least 12 years of
experience in pharmaceutical or biotechnology industries
, 5-8 years of experience leading projects or teamsDemonstrated success applying cellular and molecular pharmacology in vitro biology tools to support and advance drug discovery programs with an emphasis of GPCR drug discoveryIn depth knowledge of GPCR molecular pharmacology with specific expertise characterizing mechanism of action, potency, and efficacy of hits and leadsExposure to structured-guided GPCR drug discovery desiredExperience with both ex-vivo and in vivo translational models desiredExcellent communication and organizational skillsFlexibility and ability to quickly learn new skills and knowledge on the jobABOUT IAMBIC THERAPEUTICSIambic Therapeutics is disrupting the therapeutics landscape with its cutting-edge generative AI drug discovery platform. We have assembled a world-class team that unites pioneering AI experts and seasoned drug hunters with strong track records of success in delivering clinically validated breakthrough treatments. The Iambic Therapeutics platform has been demonstrated to deliver high quality, differentiated drugs to clinic with unprecedented speed and across multiple target classes and mechanisms of action. We are focused on the advancement on our internal pipeline of clinical assets to address urgent unmet patient need in oncology and other therapeutic areas.MISSION & CORE VALUESThe culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.BENEFITSWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life Insurance, 401K matching, and unlimited vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
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The successful candidate will have a proven track record driving GPCR drug discovery programs from target validation through lead optimization.
This person will join the biology team and advance our core mission of accelerating drug discovery programs leveraging AI. The candidate will work closely with a cross-functional team that integrates machine learning, medicinal chemistry, analytical technology and biology to revolutionize small-molecule therapeutics design and discovery.RESPONSIBILITIESHelp guide strategy around GPCR drug discovery efforts, mentor and inspire a team of in vitro pharmacology and lead generation scientists to achieve data-driven outcomes efficiently, leveraging both internal and external resourcesPartner with senior leadership to communicate vision and innovation in drug discovery in alignment with company goals.Lead GPCR in vivo and in vitro pharmacology effortsLead and manage internal GPCR assay development (biochemistry and cell biology)Drive GPCR drug discovery programsLead pharmacology efforts to support the advancement of GPCR drug discovery projects from hit ID through development candidate selectionIndependently manage CRO scientists in the design, development, and implementation of in vitro/in vivo assays for the advancement of GPCR projectsGuide KOL interaction and research strategy for exploratory and early stage GPCR drug discovery effortsLead biology function within a multi-disciplinary teams/project which includes setting priorities, effectively communicating with, coordinating efforts and motivating team members.REQUIREMENTSPhD in biochemistry
, pharmacology
or related field with a high level of expertise in GPCR pharmacologyAt least 12 years of
experience in pharmaceutical or biotechnology industries
, 5-8 years of experience leading projects or teamsDemonstrated success applying cellular and molecular pharmacology in vitro biology tools to support and advance drug discovery programs with an emphasis of GPCR drug discoveryIn depth knowledge of GPCR molecular pharmacology with specific expertise characterizing mechanism of action, potency, and efficacy of hits and leadsExposure to structured-guided GPCR drug discovery desiredExperience with both ex-vivo and in vivo translational models desiredExcellent communication and organizational skillsFlexibility and ability to quickly learn new skills and knowledge on the jobABOUT IAMBIC THERAPEUTICSIambic Therapeutics is disrupting the therapeutics landscape with its cutting-edge generative AI drug discovery platform. We have assembled a world-class team that unites pioneering AI experts and seasoned drug hunters with strong track records of success in delivering clinically validated breakthrough treatments. The Iambic Therapeutics platform has been demonstrated to deliver high quality, differentiated drugs to clinic with unprecedented speed and across multiple target classes and mechanisms of action. We are focused on the advancement on our internal pipeline of clinical assets to address urgent unmet patient need in oncology and other therapeutic areas.MISSION & CORE VALUESThe culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.BENEFITSWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life Insurance, 401K matching, and unlimited vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
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