Associate Scientist

DescriptionPosition SummaryWorks independently to perform and interpret in vitro cellular functional assays using primary mammalian cells and cell lines and to identify and characterize antibodies using some or all of the following methods: in vitro screening methodologies such as single B cell PCR, single B cell expansion, expression assays, binding assays, ELISA, MSD, and multiplex analysis assays including flow cytometry. Responsibilities also include developing and performing novel cellular assays and evaluating activity of specific antibodies from AnaptysBio’s discovery and affinity maturation platform.Essential FunctionsDevelop, optimize and perform new methods and technologies for antibody discovery to specific targets which may include novel applications of molecular biology and/or cellular biology.Develop, optimize, and perform ELISA, MSD, flow cytometry, and in vitro cellular functional assays, including potential intracellular signaling assays to characterize antibodies in support of discovery programs.Formulate experimental plans to achieve scientific goals in new and creative ways.Design and accurately execute experiments.Analyze and interpret experimental results and make recommendations for action/further research.Organize, summarize and clearly present data at project team meetings and to senior management.Lead cross-functional antibody discovery with cell biology, molecular biology and protein sciences.Prepare experimental write-ups for research reports, transfer to external CRO/collaborators, patent applications and manuscripts.Apply scientific literature to solve problems and formulate new ideas.Identify potentially patentable inventions.Direct the activities of team members when necessary.Supervisory ResponsibilitiesNoneRequirementsQualificationsEducation & Experience:Bachelors’ degree in a biology-related discipline.10 years related laboratory experience or Masters’ in a biology-related discipline with 8 years related laboratory research experience.Knowledge and Competencies:Functional knowledge of, and working experience in, principles and practices of molecular and cell biology methodologies and cellular immunology, which will include some or all of the following: mammalian cell culture, cell transfection, functional/in-vitro cellular immunology assays and cellular assay development, multiplex assays, single cell PCR, and DNA cloning techniques.Experience in executing cellular signaling assays including ELISA, luminescence, and flow cytometry-based readouts.Experience in primary mammalian lymphocyte and mononuclear cell purification and functional assays.Proficiency in basic computer data analysis and presentation applications, Microsoft Word, Excel, PowerPoint.Able to work with limited supervision, and effectively within a team setting, and design experiments to answer specific scientific questions.Able to learn new laboratory techniques efficiently, troubleshoot experiments, and ensure experiments are well designed and performed to a high standard.Physical DemandsThe physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.While performing the duties of this job, the employee is regularly required to sit and talk or hear. The employee frequently is required to use hands to finger, handle, or feel. The employee is occasionally required to stand, walk, and reach with hands and arms. The employee must occasionally lift and/or move up to 10 pounds. Specific vision abilities required by this job include close vision and ability to adjust focus in order to read.Work EnvironmentThe work environment characteristics are representative of those an employee encounters while performing the essential functions of this job, typically in an open office environment. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.The noise level in the work environment is usually moderate.May be required to travel by plane or car.This position requires working with biological and/or chemical hazards.All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status.

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