Principal Scientist with PhenoCycler Fusion experience (PhD)

Job Description SummaryWe are seeking a highly motivated individual passionate about cutting-edge technology to explore single cell multiplex spatial proteomics. This role involves working with the latest generation PhenoCycler Fusion instrument and collaborating with translational immunologists, cancer biologists, and other researchers to advance our understanding of cellular processes in complex tissues and their application to drug development. This role offers exciting opportunities for career development, enhancing leadership skills and influencing collaborative efforts within various disease areas.Job DescriptionInternal Job Title: Principal Scientist I/IIPosition Location: Cambridge, MA, onsiteAbout the Role:We are seeking a highly motivated individual passionate about cutting-edge technology to explore single cell multiplex spatial proteomics. This role involves working with the latest generation PhenoCycler Fusion instrument and collaborating with translational immunologists, cancer biologists, and other researchers to advance our understanding of cellular processes in complex tissues and their application to drug development.Key Responsibilities:Operate, maintain, and utilize the PhenoCycler Fusion (formerly CODEX).Build and optimize antibody panels.Conjugate and perform quality control of reagents.Consult with users on potential projects, including sample accessibility and experimental design.Optimize procedures, design panels, and provide data analysis consultation.Conduct multiplex imaging experiments.Perform basic data quality evaluation.Analyze data using licensed software.Maintain records of procedures and resultant data, both manually and on the computer.Knowledge, Skills, and Abilities:Serve as a leader in spatial proteomic single cell biology and translational research applications, focusing on new targets, biomarkers/patient population selection, and treatment strategies.Focus efforts in priority application areas in Biomedical Research (BR) at Novartis to deliver impactful results through matrix collaboration with DA teams.Building on success from initial focused efforts, develop broader application strategies at BR in translational and reverse translation research, with support from leaders in Discovery Science, Disease Areas and Biomedical Research.Strong interpersonal and communication skills for close collaboration with team members.Ability to work effectively in a fast-paced, diverse environment.Good judgment, technical problem-solving, and analytical skills.Flexibility and adaptability as technology evolves.Prior experience in imaging techniques and applications in biological research.General lab skills and knowledge of lab safety and infection control.Qualifications:Ph.D. in immunology, biological sciences, biochemistry, or a related field, and 2+ years of related postgraduate work experience.Other technical and academic degrees will be considered with relevant research experience.3+ years of demonstrated skill and experience using CODEX/PhenoCycler.Possess deep knowledge and expertise in immunology, biology, and multi-omics applications in translational research across various disease areas such as oncology (ONC), immuno-oncology (IO), immunity-driven diseases, and related treatment strategies.Understanding sample preparation, instrument optimization, and data analysis.Interest in bioinformatics and experience with software.Ability to identify and troubleshoot critical issues.Detail-oriented.

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