Gilead Sciences, Inc.
Associate Scientist- Protein Therapeutics
Gilead Sciences, Inc., Foster City, California, United States, 94420
Associate Scientist- Protein Therapeutics
Locations: United States - California - Foster CityTime Type: Full timePosted on: Vor 4 Tagen ausgeschriebenJob Requisition ID: R0042402At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19, and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. We’re looking for the next wave of passionate and ambitious people ready to make a direct impact.Job DescriptionThe Protein Engineering group is a specialized team within the Protein Therapeutics department responsible for the optimization and engineering of large molecule drug candidates. We seek a highly motivated Associate Scientist to contribute to the engineering of novel antibody binding domains, fusion proteins (e.g., cytokines), and multispecific formats using structure-based rational and/or computational design approaches. The successful candidate will support cross-functional project teams to develop novel biologics for clinical development.Essential Duties and Job Functions:Advance engineering technologies to enable large molecule drug development.Enable rapid optimization of novel antibody and protein therapeutics via humanization, structure-based design, and/or library-based approaches.Characterize the binding and functional properties of novel antibodies, multispecifics, immunocytokines, and other biologics.Maintain familiarity with scientific literature and independently design, execute, analyze, and interpret experiments.Effectively communicate and present project goals and experimental findings to diverse audiences.Organize and execute multiple projects in a collaborative team setting.Thrive in a fast-paced, data-driven, and scientifically rigorous environment.Maintain compliance with company policies and record keeping.Knowledge, Experience and Skills:Applicants must have a B.S./M.S. in molecular biology, biochemistry, structural biology or a related field, with a minimum of 5+ for B.S./3+ for M.S. years of relevant professional experience. An ideal candidate will have experience in most of the following areas:Proficient in antibody humanization, liability remediation, and generating different multispecific formats, immunocytokines, and fusion proteins.Experience with mammalian cell culture, protein expression, purification, and characterization.Familiarity with structure-based protein engineering and design. Experience using computational design software (e.g., Rosetta, MPNN, etc.) is a plus.Experience with biochemical assays and quantitative analysis of protein-protein binding interactions (e.g., cell-based reporter assays, FACS, ELISA, Octet, Carterra, etc.).Experience with molecular biology techniques including cloning, vector design, and mutagenesis.Familiarity with in vitro display technologies and library design is a plus.Excellent communication and organizational skills.Ability to multi-task and self-motivated with excellent problem-solving skills.Preferred Experience:An ideal candidate will preferably have 7+ for B.S./5+ for M.S. years of industry experience.The salary range for this position is: $124,015.00 - $160,490.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives, paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans.For additional benefits information, visit:
Gilead BenefitsAs an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws.Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis, and cancer.
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Locations: United States - California - Foster CityTime Type: Full timePosted on: Vor 4 Tagen ausgeschriebenJob Requisition ID: R0042402At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19, and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. We’re looking for the next wave of passionate and ambitious people ready to make a direct impact.Job DescriptionThe Protein Engineering group is a specialized team within the Protein Therapeutics department responsible for the optimization and engineering of large molecule drug candidates. We seek a highly motivated Associate Scientist to contribute to the engineering of novel antibody binding domains, fusion proteins (e.g., cytokines), and multispecific formats using structure-based rational and/or computational design approaches. The successful candidate will support cross-functional project teams to develop novel biologics for clinical development.Essential Duties and Job Functions:Advance engineering technologies to enable large molecule drug development.Enable rapid optimization of novel antibody and protein therapeutics via humanization, structure-based design, and/or library-based approaches.Characterize the binding and functional properties of novel antibodies, multispecifics, immunocytokines, and other biologics.Maintain familiarity with scientific literature and independently design, execute, analyze, and interpret experiments.Effectively communicate and present project goals and experimental findings to diverse audiences.Organize and execute multiple projects in a collaborative team setting.Thrive in a fast-paced, data-driven, and scientifically rigorous environment.Maintain compliance with company policies and record keeping.Knowledge, Experience and Skills:Applicants must have a B.S./M.S. in molecular biology, biochemistry, structural biology or a related field, with a minimum of 5+ for B.S./3+ for M.S. years of relevant professional experience. An ideal candidate will have experience in most of the following areas:Proficient in antibody humanization, liability remediation, and generating different multispecific formats, immunocytokines, and fusion proteins.Experience with mammalian cell culture, protein expression, purification, and characterization.Familiarity with structure-based protein engineering and design. Experience using computational design software (e.g., Rosetta, MPNN, etc.) is a plus.Experience with biochemical assays and quantitative analysis of protein-protein binding interactions (e.g., cell-based reporter assays, FACS, ELISA, Octet, Carterra, etc.).Experience with molecular biology techniques including cloning, vector design, and mutagenesis.Familiarity with in vitro display technologies and library design is a plus.Excellent communication and organizational skills.Ability to multi-task and self-motivated with excellent problem-solving skills.Preferred Experience:An ideal candidate will preferably have 7+ for B.S./5+ for M.S. years of industry experience.The salary range for this position is: $124,015.00 - $160,490.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives, paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans.For additional benefits information, visit:
Gilead BenefitsAs an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws.Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis, and cancer.
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