ViiV Scientific Director

ViiV Healthcare is looking for a Scientific Leader to join the Discovery DMPK (drug metabolism and pharmacokinetic) team based in Branford CT as a Project Specialist focused on discovering new medicines for the treatment, prevention and cure of HIV. As an individual contributor, the DMPK Project Specialist ensures that our DMPK science is embedded in Discovery projects across all modalities (small and large molecule) from commit to target through Phase I clinical work, and is accountable for driving the translational understanding of drug disposition and pharmacokinetic-pharmacodynamic (PKPD) approaches for projects that may include both oral and long-acting injectable medicines. The role requires working within matrix teams to design, complete and interpret in vitro and in vivo ADME studies, providing DMPK strategic leadership to discovery project teams, and contributing to the overall direction of our DMPK science to ensure that innovation is aligned with portfolio deliverables. Finally, the role has a significant writing component to contribute to internal reports, technical evidence, ADME reports and regulatory documents (e.g., IND, Investigator's Brochure).This role will provide the opportunity to lead key activities and to progress your career. These responsibilities include:Drive the DMPK strategy for multiple Drug Discovery stage projects from early lead optimization through Phase I clinical studies.Ensure that translational PKPD approaches and appropriate screening cascades with multi-parametric optimization are being applied to assigned projects.Utilize your extensive laboratory experience to design and conduct/oversee bespoke mechanism-based studies to address program needs.Efficiently manage your time and project requests for DMPK work to ensure optimal support of projects across different modalities in the ViiV Discovery pipeline.Coordinate and deliver high-quality DMPK written contributions to technical and regulatory documents.Develop and maintain excellent working relations with stakeholders in Discovery project teams, in order to ensure strategic alignment.Actively support cross-DMPK initiatives as a representative from the ViiV Nonclinical Safety and DMPK team to drive DMPK science and operations.Basic Qualifications:MS Degree (7 years' experience) or PhD (>2 years' experience post graduation) in a field relevant to DMPK (e.g., Pharmacology, Biochemistry, Pharmacokinetics or Drug Metabolism).Experience state-of-the-art DMPK science in projects to enable the discovery of new medicines, including experience with small molecules and biologics drug discovery and/or development.Experience managing DMPK related project resources and budgets.Experience working in cross-matrix teams, with demonstrated experience in project milestone delivery.Preferred Qualifications:PhD in a field relevant to DMPK (e.g., Pharmacology, Biochemistry, Pharmacokinetics or Drug Metabolism) with >5 years drug discovery experience.In-depth experience in DMPK representation in Discovery projects across different modalities (e.g., small molecule, mAb, long-acting injectable) and has strong experience in human dose prediction.Examples demonstrating the successful selection of drug candidates through efficient ADME screening cascades such as multi-parametric optimization, translational PKPD and human dose optimization strategies.Experience in leveraging modeling approaches and predictive science in Discovery projects to accelerate timelines and increase probability of success.Excellent communication/written skills and collaboration as demonstrated through publication and/or external interactions (e.g., university collaborations, speaking invitations etc.).

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