AstraZeneca
Director, In Vivo Pharmacology Oncology Research
AstraZeneca, Gaithersburg, Maryland, us, 20883
Director, In Vivo Pharmacology Oncology Research
Gaithersburg, MD
At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world.
This Opportunity
We are seeking a highly motivated and independent Director with experience in cancer biology and a track record of scientific excellence to join our In Vivo Pharmacology Team in Gaithersburg, MD USA. As a Director in In Vivo Pharmacology, you will be leading research to evaluate the efficacy and mechanisms of action of antibody drug conjugates (ADCs), therapeutic antibodies, and nanomedicines.
Key Duties and Responsibilities
Working within the Early Oncology In Vivo Pharmacology Team, you will develop, design, and analyze both in vivo and in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics. You will be expected to collaborate with cross-functional teams including representatives from translational medicine, drug metabolism, pharmacokinetics, and safety to help understand the translatability of in vivo research to the clinic.
Essential Requirements
Ph.D. in relevant field with >7 years of research experience in cancer biology or pharmacology.
Biotechnology or pharmaceutical industry experience required.
Experience directing or managing an in vivo pharmacology team.
Experience with in vivo pharmacology of Antibody Drug Conjugates (ADCs).
Experience developing and working with complex in vivo models, such as xenograft, patient derived xenograft (PDX), syngeneic and autochthonous mouse models.
Experience delivering in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies.
Experience with a range of in vitro skills, e.g. cell culture, molecular biology, immunoblotting, flow cytometry and ELISA.
Works independently, assesses, and reports data in a clear and concise manner.
Maintains a well-developed understanding of approaches to drug discovery.
Ability to drive, manage, execute and deliver results for complex multi-functional projects.
Proven ability to manage, motivate, and develop direct reports.
Strong interpersonal and collaboration skills.
Excellent communication and presentation skills.
A proven track record of high productivity and scientific publications in peer reviewed journals.
Desirable Requirements
Experience with orthotopic xenograft and humanized models of cancer.
Experience conducting in vivo research using biologics including peptides, antibodies, antibody-drug conjugates and oncolytic viruses.
Experience designing, conducting and analyzing multi-spectral flow cytometry immune-phenotyping studies.
Experience in drug development in pharmaceutical or biotech industries.
Experience in managing external collaborations.
About Our Gaithersburg Oncology Hub
Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US.
Ready to make a meaningful difference? Apply now and join us in our mission to eliminate cancer as a cause of death!
If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.
Closing Date: September 20, 2024
Competitive remuneration and benefits apply
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds.
#J-18808-Ljbffr
Gaithersburg, MD
At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world.
This Opportunity
We are seeking a highly motivated and independent Director with experience in cancer biology and a track record of scientific excellence to join our In Vivo Pharmacology Team in Gaithersburg, MD USA. As a Director in In Vivo Pharmacology, you will be leading research to evaluate the efficacy and mechanisms of action of antibody drug conjugates (ADCs), therapeutic antibodies, and nanomedicines.
Key Duties and Responsibilities
Working within the Early Oncology In Vivo Pharmacology Team, you will develop, design, and analyze both in vivo and in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics. You will be expected to collaborate with cross-functional teams including representatives from translational medicine, drug metabolism, pharmacokinetics, and safety to help understand the translatability of in vivo research to the clinic.
Essential Requirements
Ph.D. in relevant field with >7 years of research experience in cancer biology or pharmacology.
Biotechnology or pharmaceutical industry experience required.
Experience directing or managing an in vivo pharmacology team.
Experience with in vivo pharmacology of Antibody Drug Conjugates (ADCs).
Experience developing and working with complex in vivo models, such as xenograft, patient derived xenograft (PDX), syngeneic and autochthonous mouse models.
Experience delivering in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies.
Experience with a range of in vitro skills, e.g. cell culture, molecular biology, immunoblotting, flow cytometry and ELISA.
Works independently, assesses, and reports data in a clear and concise manner.
Maintains a well-developed understanding of approaches to drug discovery.
Ability to drive, manage, execute and deliver results for complex multi-functional projects.
Proven ability to manage, motivate, and develop direct reports.
Strong interpersonal and collaboration skills.
Excellent communication and presentation skills.
A proven track record of high productivity and scientific publications in peer reviewed journals.
Desirable Requirements
Experience with orthotopic xenograft and humanized models of cancer.
Experience conducting in vivo research using biologics including peptides, antibodies, antibody-drug conjugates and oncolytic viruses.
Experience designing, conducting and analyzing multi-spectral flow cytometry immune-phenotyping studies.
Experience in drug development in pharmaceutical or biotech industries.
Experience in managing external collaborations.
About Our Gaithersburg Oncology Hub
Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US.
Ready to make a meaningful difference? Apply now and join us in our mission to eliminate cancer as a cause of death!
If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.
Closing Date: September 20, 2024
Competitive remuneration and benefits apply
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds.
#J-18808-Ljbffr