Director, In Vivo Pharmacology Oncology Research

Director, In Vivo Pharmacology Oncology ResearchGaithersburg, MDAt AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.This OpportunityWe are seeking a highly motivated and independent Director with experience in cancer biology and a track record of scientific excellence to join our In Vivo Pharmacology Team in Gaithersburg, MD USA. As a Director in In Vivo Pharmacology, you will be leading research to evaluate the efficacy and mechanisms of action of antibody drug conjugates (ADCs), therapeutic antibodies, and nanomedicines.Key Duties and ResponsibilitiesWorking within the Early Oncology In Vivo Pharmacology Team, you will develop, design, and analyze both in vivo and in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics. You will collaborate with cross-functional teams including representatives from translational medicine, drug metabolism, pharmacokinetics, and safety to help understand the translatability of in vivo research to the clinic. You will work collaboratively with project leaders to ensure the timely generation and dissemination of critical program data, and contribute to scientific publication goals.Essential RequirementsPh.D. in relevant field with >7 years of research experience in cancer biology or pharmacology.Biotechnology or pharmaceutical industry experience required.Experience directing or managing an in vivo pharmacology team.Experience with in vivo pharmacology of Antibody Drug Conjugates (ADCs).Experience developing and working with complex in vivo models, such as xenograft, patient derived xenograft (PDX), syngeneic and autochthonous mouse models.Experience delivering in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies.Experience with a range of in vitro skills, e.g. cell culture, molecular biology, immunoblotting, flow cytometry and ELISA.Works independently, assesses, and reports data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery.Maintains a well-developed understanding of approaches to drug discovery and applies a broader functional knowledge of the procedures used by diverse project groups to support the department where needed.Ability to drive, manage, execute and deliver results for complex multi-functional projects.Proven ability to manage, motivate, and develop direct reports.Strong interpersonal and collaboration skills together with evidence of delivery in a team-oriented, collaborative environment.Excellent communication and presentation skills to report data in a clear and concise manner.A proven track record of high productivity and scientific publications in peer reviewed journals.Desirable RequirementsExperience with orthotopic xenograft and humanized models of cancer.Experience conducting in vivo research using biologics including, peptides, antibodies, antibody-drug conjugates and oncolytic viruses.Experience designing, conducting and analyzing multi-spectral flow cytometry immune-phenotyping studies.Experience in drug development in pharmaceutical or biotech industries.Experience in managing external collaborations.Closing Date: September 20, 2024Competitive remuneration and benefits applyWe offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.

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