Houston Methodist
Postdoctoral Fellow - Neurosurgery - Rostomily lab
Houston Methodist, Houston, Texas, United States, 77246
At Houston Methodist, the Postdoctoral Fellow position is responsible for performing basic research duties under the supervision/direction of a Physician and/or Principal Investigator (PI). This position may work in a laboratory setting or may consist of computer work that supports the department's research mission.Preferred Candidates:
Experience in neural cell culture, electrophysiology, neural or cancer stem cell culture and phenotyping, CNS mouse models of neural disease or cancer, optogenetics and/or fluorescent readouts and high throughput drug screens is essential.The Rostomily Lab at Houston Methodist Research Institute is seeking a postdoctoral fellow with an interest in pursuing a novel aspect of the emerging field of “Cancer Neuroscience.” The NINDS and NCI funded studies leverage glioblastoma (GBM) stem cell (GSC) electrophysiology as a therapeutic target. In collaboration with investigators at HMRI (Phil Horner), Baylor College of Medicine (Francois St. Pierre and Ben Arenkiel) and TAMU IBT (Cliff Stephan), we seek to determine how modulation of resting GSC voltage membrane potential (Vmem) affects malignant properties of GSCs including proliferation, differentiation, and response to standard therapies like TMZ. One project utilizes patterned optogenetic modulation of Vmem in GSCs in vitro and in vivo while a second project seeks to develop a multiplexed platform for high-throughput drug screening using genetically encoded voltage indicators (GEVIs) and live cell fluorescent reporters of cell cycle (FUCCI) and G0-G1 transition (p27). The unifying principle behind these projects is that GSC hyperpolarization can reprogram GSCs to a less malignant non-stem cell phenotype with increased treatment responsiveness. The studies employ multiple techniques including whole cell patch clamp, high-throughput patch clamp, voltage, and cell cycle reporter imaging, GSC phenotyping, xenograft glioma models, in vitro and in vivo optogenetic manipulation of GSCs, and high throughput ion channel drug screening. Positions are open for both projects immediately. The positions are supported from the following grants:“Patterned optogenetic neuromodulation to reprogram glioma stem cells.” 1R21NS127229“A multiplexed high-throughput platform to report pharmacologic alteration of cancer stem cell membrane potential and cell cycle state.” 1R61CA278458
PEOPLE ESSENTIAL FUNCTIONSAssists the physician and/or Principal Investigator (PI) in maintaining the functionality and operations of the Principal Investigator's (PI) laboratory.Promotes a positive work environment and leads the team to be dynamic and a focused work unit that actively helps one another to achieve optimal department results. Collaborates with all members of the department by actively communicating and reporting data in a comprehensive manner.Role models to team members effective verbal, non-verbal and written communication, which includes active listening and teaching, assisting in the development of such skills.Provides contributions towards improvement of department scores for employee engagement, i.e. peer-to-peer accountability.
SERVICE ESSENTIAL FUNCTIONSDevelops research methods and performs research activities.Documents research results and writes reports of results for presentation and/or publication in professional journals and other publications.
QUALITY/SAFETY ESSENTIAL FUNCTIONSFollows all safety rules while on the job. Reports accidents promptly and corrects minor safety hazards. Communicates with peers and management regarding any hazards identified in the workplace.Assists with implementation and education of department-based safety initiatives, standards of practice and protocols. Develops skills of team members and continually assists with improving skills, performance and outcomes.Identifies opportunities for corrective action and process improvement providing recommendations and contributes to meeting department and laboratory targets for quality and safety.
FINANCE ESSENTIAL FUNCTIONSUtilizes resources effectively and efficiently, demonstrating responsible financial stewardship. Manages own time effectively and prioritizes work to achieve maximum results in a timely manner.Uses resources efficiently; does not waste supplies. Self-motivated to independently manage time effectively and prioritize daily tasks.
GROWTH/INNOVATION ESSENTIAL FUNCTIONSParticipates in pertinent research activities and evidenced-based practice projects. Participates in departmental projects and activities. Acts as a change agent.Seeks opportunities to expand learning beyond baseline competencies with a focus on continual development. Remains current on professional issues and clinical skills. Completes and updates the My Development Plan on an on-going basis. Ensures own career discussions occur with appropriate management.
This job description is not intended to be all-inclusive; the employee will also perform other reasonably related business/job duties as assigned. Houston Methodist reserves the right to revise job duties and responsibilities as the need arises.
EDUCATIONPostdoctoral Fellow 0, 1, 2, 3, 4 - Doctor of Medicine (MD) from an accredited medical school or Terminal degree in a related field (A letter from the academic institution certifying that all student work is complete will be considered for Postdoctoral Fellow 0 only).
WORK EXPERIENCEPostdoctoral Fellow 0 - NonePostdoctoral Fellow 1 - One year of Postdoc experiencePostdoctoral Fellow 2 - Two years' Postdoc experiencePostdoctoral Fellow 3 - Three years' Postdoc experiencePostdoctoral Fellow 4 - Four years' Postdoc experience.
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Experience in neural cell culture, electrophysiology, neural or cancer stem cell culture and phenotyping, CNS mouse models of neural disease or cancer, optogenetics and/or fluorescent readouts and high throughput drug screens is essential.The Rostomily Lab at Houston Methodist Research Institute is seeking a postdoctoral fellow with an interest in pursuing a novel aspect of the emerging field of “Cancer Neuroscience.” The NINDS and NCI funded studies leverage glioblastoma (GBM) stem cell (GSC) electrophysiology as a therapeutic target. In collaboration with investigators at HMRI (Phil Horner), Baylor College of Medicine (Francois St. Pierre and Ben Arenkiel) and TAMU IBT (Cliff Stephan), we seek to determine how modulation of resting GSC voltage membrane potential (Vmem) affects malignant properties of GSCs including proliferation, differentiation, and response to standard therapies like TMZ. One project utilizes patterned optogenetic modulation of Vmem in GSCs in vitro and in vivo while a second project seeks to develop a multiplexed platform for high-throughput drug screening using genetically encoded voltage indicators (GEVIs) and live cell fluorescent reporters of cell cycle (FUCCI) and G0-G1 transition (p27). The unifying principle behind these projects is that GSC hyperpolarization can reprogram GSCs to a less malignant non-stem cell phenotype with increased treatment responsiveness. The studies employ multiple techniques including whole cell patch clamp, high-throughput patch clamp, voltage, and cell cycle reporter imaging, GSC phenotyping, xenograft glioma models, in vitro and in vivo optogenetic manipulation of GSCs, and high throughput ion channel drug screening. Positions are open for both projects immediately. The positions are supported from the following grants:“Patterned optogenetic neuromodulation to reprogram glioma stem cells.” 1R21NS127229“A multiplexed high-throughput platform to report pharmacologic alteration of cancer stem cell membrane potential and cell cycle state.” 1R61CA278458
PEOPLE ESSENTIAL FUNCTIONSAssists the physician and/or Principal Investigator (PI) in maintaining the functionality and operations of the Principal Investigator's (PI) laboratory.Promotes a positive work environment and leads the team to be dynamic and a focused work unit that actively helps one another to achieve optimal department results. Collaborates with all members of the department by actively communicating and reporting data in a comprehensive manner.Role models to team members effective verbal, non-verbal and written communication, which includes active listening and teaching, assisting in the development of such skills.Provides contributions towards improvement of department scores for employee engagement, i.e. peer-to-peer accountability.
SERVICE ESSENTIAL FUNCTIONSDevelops research methods and performs research activities.Documents research results and writes reports of results for presentation and/or publication in professional journals and other publications.
QUALITY/SAFETY ESSENTIAL FUNCTIONSFollows all safety rules while on the job. Reports accidents promptly and corrects minor safety hazards. Communicates with peers and management regarding any hazards identified in the workplace.Assists with implementation and education of department-based safety initiatives, standards of practice and protocols. Develops skills of team members and continually assists with improving skills, performance and outcomes.Identifies opportunities for corrective action and process improvement providing recommendations and contributes to meeting department and laboratory targets for quality and safety.
FINANCE ESSENTIAL FUNCTIONSUtilizes resources effectively and efficiently, demonstrating responsible financial stewardship. Manages own time effectively and prioritizes work to achieve maximum results in a timely manner.Uses resources efficiently; does not waste supplies. Self-motivated to independently manage time effectively and prioritize daily tasks.
GROWTH/INNOVATION ESSENTIAL FUNCTIONSParticipates in pertinent research activities and evidenced-based practice projects. Participates in departmental projects and activities. Acts as a change agent.Seeks opportunities to expand learning beyond baseline competencies with a focus on continual development. Remains current on professional issues and clinical skills. Completes and updates the My Development Plan on an on-going basis. Ensures own career discussions occur with appropriate management.
This job description is not intended to be all-inclusive; the employee will also perform other reasonably related business/job duties as assigned. Houston Methodist reserves the right to revise job duties and responsibilities as the need arises.
EDUCATIONPostdoctoral Fellow 0, 1, 2, 3, 4 - Doctor of Medicine (MD) from an accredited medical school or Terminal degree in a related field (A letter from the academic institution certifying that all student work is complete will be considered for Postdoctoral Fellow 0 only).
WORK EXPERIENCEPostdoctoral Fellow 0 - NonePostdoctoral Fellow 1 - One year of Postdoc experiencePostdoctoral Fellow 2 - Two years' Postdoc experiencePostdoctoral Fellow 3 - Three years' Postdoc experiencePostdoctoral Fellow 4 - Four years' Postdoc experience.
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