Senior Translational Data Scientist

Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating BT8009, a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA.Culture

is key and all Bicycle employees actively embrace and role model our company values:We are

Dedicated to our Mission . You can’t change the world if you don’t have determination.We are

One Team . We only succeed when we work together.Job Description

We are looking to recruit a Senior Data Scientist with a strong software engineering and data analytics skillset as well as an oncology background to join our Translational Sciences team. This person would be responsible for leading the development, customization, and maintenance of a biomarker software solution to support our clinical-stage oncology portfolio assets. Key responsibilities would include leading data ingestion, integration, and data visualization efforts for our targeted toxin and immune-oncology clinical programs. Additional responsibilities include managing external scientists/programmers and leading the development of an integrated non-clinical/clinical biomarker database to support both forward and reverse translation.Lead the development, customization, and maintenance of a biomarker software solution to support clinical-stage oncology assets

Technically contribute to and strategically manage external programmers to develop data ingestion, processing, and wrangling pipelinesLead the migration of internal R-scripts and Shiny apps onto the software solutionSupport the integration, analysis, and visualization of biomarker and clinical data within and across targeted toxins and immune-oncology clinical trial programsProvide platform training and support to Bicycle scientists

Support data management and integration of translationally focused preclinical and clinical datasets (e.g. Nanostring, NGS)Support reverse translation analytics activities by integrating relevant internal and external datasets as well as developing clear analyses and visualizationsWork in a cross-functional environment and communicate effectively across project teams that consist of data scientists, translational scientists, IT managers/analysts, pharmacologists, clinical scientists, etc.Effectively document data transfer specs, R scripts, and data analysis processesQualifications

Experience building, customizing, and/or using clinical biomarker software solutionsStrong computational skillset, including proficiency in at least one coding language (ideally R), and ability to perform the following tasks:

Data ingestion, wrangling, integration, and analysisDesign (both strategically and technically) bioinformatics pipelinesDevelopment of clear and effective data visualizationsUnderstanding of Shiny apps (or other UI strategies)

Strong software engineering skills including familiarity with AWS, Posit, and GitlabFamiliarity with the oncology field and oncology-focused biomarker datasetsTakes initiative, asks questions, and independently moves projects along in a fast-paced environmentTeam player, conscientious, organized, and creativeExperience working with EDC and/or biomarker data from clinical trialsExperience in LSAFAdditional Information

Flexible working environmentCompetitive reward including annual company bonusMedical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the CompanyHealth and Dependent Care Flexible Spending Accounts401(k) plan with a 4% Company match and immediate vestingEligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional daysEmployee assistance program10 Company holidaysCompetitive Family Leave PolicyEligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.All your information will be kept confidential according to EEO guidelines.Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.

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