Johnson & Johnson
Senior Principal Scientist, Immunotoxicology
Johnson & Johnson, San Diego, California, United States, 92189
Johnson and Johnson is currently seeking a Senior Principal Scientist, Immunotoxicology located onsite in La Jolla, CA.
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at
https://www.jnj.com/ .
For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world’s most pressing healthcare challenges.
An exciting scientific leadership opportunity is open in the Immunotoxicology group within Preclinical Sciences and Translational Safety’s Pathobiology Organization at Johnson & Johnson for a highly skilled and critically thinking scientific leader that works exceptionally well in a fast-paced, collaborative team environment.
Primary responsibilities:
Support portfolio progression of new therapeutics across therapeutic areas and multiple drug modalities (e.g. biologics, small molecules, oligonucleotides, gene therapy, cell therapy, and peptides) by evaluating and characterizing potential and observed immunotoxicological risks and immunopharmacological mechanisms.
Make recommendations to drug discovery and development teams and communicate experimental rationale and scientific strategies to decipher/predict mechanisms of potential safety signals on the immune system.
Independently lead investigative strategies/studies to explore mechanisms of immunotoxicity/immunopharmacology using appropriate technologies, including flow cytometry, specialized imaging, differentiated stem cell culture models, complex and long-term primary cell culture models, biochemical assays, and multiplex immunoassay systems.
Interpret and communicate complex data sets to deliver timely and decisional quality insights to inform decision-making processes throughout program progression from target characterization to the clinic.
Serve on drug discovery & development teams as an active scientific matrix leader providing immunotoxicology expertise for our expanding portfolio, while also being directly involved in matrix leadership and mentorship to our technologically advanced La Jolla, California-based laboratory.
Interfacing with CRO partners for collaborating on immunotoxicology analyses on in vivo toxicology studies, addressing health authority queries on cross-functional teams, participating in issue resolution teams, and managing laboratory strategy and operations as well as data integrity initiatives.
Expand breadth of knowledge and external influence by maintaining professional memberships in external organizations (e.g. SOT, ACT, BioSafe, HESI Immunosafety Committee) and attend and/or participate in scientific meetings to increase visibility of self and J&J Innovative Medicine, through external presentations and publications.
Support career development and immunology learnings across the organization.
Qualifications
Education:
Bachelor’s degree required
Master’s degree or PhD within the field of Immunology, Toxicology or related field highly preferred
Required:
8+ years of working specifically with Immunotoxicologic considerations in Drug Discovery & Development
Abundant wealth of experience that translates into a high level of independence in executing the role and responsibilities of a scientific leader
Proven ability to develop complex assays (e.g. T-cell activation assays, cytokine release hazard identification, myeloid cell activity, platelet activation and binding assessments, and/or culturing of primary leukocytes) and employ high-end technologies
Flow cytometry expertise
Demonstrated ability to research, identify, develop and transfer assays, and collaborate with CROs supporting immunotoxicological studies & risk assessment
Demonstrated track record of leading and strategizing in vitro and in vivo studies to investigate unexpected adverse findings involving immunologic (e.g., immediate hypersensitivity, mast cells, complement activation) systems
Demonstrated ability to develop biomarkers for measuring in vivo therapeutic-induced immunologic changes in preclinical species
Demonstrated track record of ensuring the quality, timeliness, and compliance of project deliverables, including data integrity and best practices for laboratory workflows and workplace safety
Experience mentoring laboratory staff as well as matrix leadership on project issue related teams
Excellent communication skills, and a demonstrated ability to work collaboratively and effectively across project teams
Preferred:
Experience addressing health authority comments/questions on immunotoxicologic safety concerns
The anticipated base pay range for this position is $135,000 to $232,300.
The anticipated base pay range for this position in the California Bay Area is $166,000 to $267,145.
The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis.
Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
Employees are eligible for the following time off benefits: Vacation – up to 120 hours per calendar year
Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year
Holiday pay, including Floating Holidays – up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year
Additional information can be found through the link below:
https://www.careers.jnj.com/employee-benefits
This job posting is anticipated to close on September 25, 2024. The Company may however extend this time-period, in which case the posting will remain available on
https://www.careers.jnj.com
to accept additional applications.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at
https://www.jnj.com/ .
For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world’s most pressing healthcare challenges.
An exciting scientific leadership opportunity is open in the Immunotoxicology group within Preclinical Sciences and Translational Safety’s Pathobiology Organization at Johnson & Johnson for a highly skilled and critically thinking scientific leader that works exceptionally well in a fast-paced, collaborative team environment.
Primary responsibilities:
Support portfolio progression of new therapeutics across therapeutic areas and multiple drug modalities (e.g. biologics, small molecules, oligonucleotides, gene therapy, cell therapy, and peptides) by evaluating and characterizing potential and observed immunotoxicological risks and immunopharmacological mechanisms.
Make recommendations to drug discovery and development teams and communicate experimental rationale and scientific strategies to decipher/predict mechanisms of potential safety signals on the immune system.
Independently lead investigative strategies/studies to explore mechanisms of immunotoxicity/immunopharmacology using appropriate technologies, including flow cytometry, specialized imaging, differentiated stem cell culture models, complex and long-term primary cell culture models, biochemical assays, and multiplex immunoassay systems.
Interpret and communicate complex data sets to deliver timely and decisional quality insights to inform decision-making processes throughout program progression from target characterization to the clinic.
Serve on drug discovery & development teams as an active scientific matrix leader providing immunotoxicology expertise for our expanding portfolio, while also being directly involved in matrix leadership and mentorship to our technologically advanced La Jolla, California-based laboratory.
Interfacing with CRO partners for collaborating on immunotoxicology analyses on in vivo toxicology studies, addressing health authority queries on cross-functional teams, participating in issue resolution teams, and managing laboratory strategy and operations as well as data integrity initiatives.
Expand breadth of knowledge and external influence by maintaining professional memberships in external organizations (e.g. SOT, ACT, BioSafe, HESI Immunosafety Committee) and attend and/or participate in scientific meetings to increase visibility of self and J&J Innovative Medicine, through external presentations and publications.
Support career development and immunology learnings across the organization.
Qualifications
Education:
Bachelor’s degree required
Master’s degree or PhD within the field of Immunology, Toxicology or related field highly preferred
Required:
8+ years of working specifically with Immunotoxicologic considerations in Drug Discovery & Development
Abundant wealth of experience that translates into a high level of independence in executing the role and responsibilities of a scientific leader
Proven ability to develop complex assays (e.g. T-cell activation assays, cytokine release hazard identification, myeloid cell activity, platelet activation and binding assessments, and/or culturing of primary leukocytes) and employ high-end technologies
Flow cytometry expertise
Demonstrated ability to research, identify, develop and transfer assays, and collaborate with CROs supporting immunotoxicological studies & risk assessment
Demonstrated track record of leading and strategizing in vitro and in vivo studies to investigate unexpected adverse findings involving immunologic (e.g., immediate hypersensitivity, mast cells, complement activation) systems
Demonstrated ability to develop biomarkers for measuring in vivo therapeutic-induced immunologic changes in preclinical species
Demonstrated track record of ensuring the quality, timeliness, and compliance of project deliverables, including data integrity and best practices for laboratory workflows and workplace safety
Experience mentoring laboratory staff as well as matrix leadership on project issue related teams
Excellent communication skills, and a demonstrated ability to work collaboratively and effectively across project teams
Preferred:
Experience addressing health authority comments/questions on immunotoxicologic safety concerns
The anticipated base pay range for this position is $135,000 to $232,300.
The anticipated base pay range for this position in the California Bay Area is $166,000 to $267,145.
The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis.
Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
Employees are eligible for the following time off benefits: Vacation – up to 120 hours per calendar year
Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year
Holiday pay, including Floating Holidays – up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year
Additional information can be found through the link below:
https://www.careers.jnj.com/employee-benefits
This job posting is anticipated to close on September 25, 2024. The Company may however extend this time-period, in which case the posting will remain available on
https://www.careers.jnj.com
to accept additional applications.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
#J-18808-Ljbffr