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How will your role help us transform hope into reality? The Therapy Area Lead, Allergy/Immunology is a strategic program leader for BLU-808, Blueprint Medicines' wild-type KIT inhibitor clinical program with development plans across multiple allergy/immunology diseases, You will be responsible for establishing the long-term vision and strategy while enabling teams to achieve strong execution of the program plan. You will provide leadership across drug development and commercialization, ensuring achievement of program goals and advancing Blueprint Medicines' leadership in mast cell-directed diseases. The ideal candidate will be a strategic leader well-versed in drug development and a strong influencer who can integrate effectively and align stakeholders across different functions and levels of the organization. Reporting to the Mast Cell Franchise Lead and Head of Program Leadership, you will champion critical portions of Blueprint Medicines' portfolio with significant executive visibility and potential for patient impact globally. What will you do? Lead the cross-functional team of leaders responsible for setting and achieving the long-term vision for BLU-808 Incorporate the long-term vision from early development onwards enabling us to optimize clinical development plans across therapeutic indications Oversee the development of cross functional strategic plans to develop, register, and commercialize BLU-808 Integrate cross functional perspectives, ensuring scientific rigor, emerging clinical data, competition, and the evolving landscape in key markets are incorporated routinely to inform program direction Work with the functional leads and senior leadership to set program goals aligned with corporate goals Manage and mentor Global Development Team Lead(s) responsible for oversight of execution of the CDP Foster strong cross functional team performance, empowering the team while driving alignment, accountability, prioritization, and timely decision making to deliver on program and corporate goals On an ongoing basis, proactively anticipate issues and ensure contingency plans are put in place; identify barriers and problem-solve to mitigate them; identify opportunities and how to capture them Communications: Champion the franchise and provide critical updates between the teams and senior leaders, ensuring strategic alignment and awareness of changes to strategy or timelines Partner with senior leadership and governance committees on long-range planning, enabling accurate projections, financial and portfolio analyses to inform resource allocation Serve as an external ambassador, fostering broad engagement to cultivate strategic KOL relationships and enabling overall integration of external insights to inform strategy Ensure ongoing monitoring of the competitive landscape, synthesis, and communication of program implications Partner with corporate communications and the Executive Team to develop communication strategies, positioning, and messaging Drive innovation by challenging the status quo and seeking internal and external best practices, contributing to strategic thinking at the program, franchise, and portfolio level

What minimum qualifications do we require? 15+ years of industry experience with 8+ years leading drug development programs BA/BS degree required

What additional qualifications will make you a stronger candidate? Advanced degree preferred (e.g., MBA, PharmD, PhD, MD, MPH, MS) Deep understanding of drug development, registration and pre-commercialization Allergy/Immunology development and/or commercialization experience strongly preferred Fully and consistently demonstrates strong communication skills across all levels and functions - able to succinctly summarize complex issues (verbally and in writing) to move team forward serving as a role model for others Fully and consistently demonstrates strategic prioritization - helping teams to pivot and manage competing priorities and changing needs in fast-paced environment - providing clarity of direction to the team An authentic leader who builds and maintains strong relationships and trust, with exceptional ability to influence key stakeholders at all levels in a matrix environment Ability to inspire, empower and motivate teams often without direct authority to cultivate high performance by creating a boundary-less environment that invites diverse perspectives, continual improvement, and opportunistic thinking Ability to attract, retain and develop talent, either as a manager, or a leader of a cross functional team A strong collaborator who communicates in an open, direct, and timely manner Strong strategic thinker and problem-solver able to anticipate challenges, identify and progress practical solutions to challenging clinical, manufacturing, regulatory, and commercial problems Flexibility and the ability to nimbly adapt to changing conditions Motivated by patient focus and personal commitment to high performance and results Possesses high integrity and exceptional work ethic Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint? At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators - the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success. This is the place where the extraordinary becomes reality, and you could be part of it. Patients are waiting. Are you ready to make the leap? Equity, Diversity, Inclusion and Affirmative Action At Blueprint Medicines, we foster a culture of equity, diversity and inclusion. A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law. We are also an E-Verify Employer. We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to TotalRewards@blueprintmedicines.com. For more information, please see ourEEO-AA Policy Statement, the E-Verify Participation Poster, the Right to Work Poster, and/or theEEO Know Your Rights Poster, as well as ourPay Transparency Statement. Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors. #LI-Hybrid #LI-AQ1