Dyne Therapeutics
Senior Research Associate, Platform Development
Dyne Therapeutics - Waltham, Massachusetts, United States, 02254
Work at Dyne Therapeutics
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Overview
Company Overview:
Dyne Therapeutics is discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. For more information, please visit
Dyne Therapeutics .
Role Summary:
Dyne is seeking a talented and highly motivated Senior Research Associate with a background in biology, chemistry, or biochemistry to help our Bioconjugation team advance therapeutics research and support drug discovery programs. This team member will collaborate closely with in vitro/in vivo biology colleagues to generate and characterize research materials and will also help establish and contribute to the operations of our laboratories.
The ideal candidate is a highly motivated individual with exceptional communication and collaboration skills. The qualified candidate will have the opportunity to build, contribute to, and expand our innovative platform technology and advance Dyne's mission of pioneering life-transforming therapies for patients with serious muscle diseases.
This role is based in Waltham, MA without the possibility of being fully remote.
Primary Responsibilities Include: Generate research therapeutic candidates for in vitro and in vivo studies Design, optimize and execute protein bioconjugation reactions with multiple proteins and payloads ranging from milligram to gram scale Utilize AKTA systems to perform purifications on raw materials and conjugates using a variety of chromatography techniques (IEX, HIC, CHT, etc.) Perform Tangential Flow Filtration (TFF; UF/DF) from milliliter to multi-Liter scale Write technical reports to support technical transfers Analyze the stability of therapeutic materials Perform biochemical analysis on in-process and final purified conjugates- including, but not limited to, the following techniques: Mass Spectrometry (LC-MS), SDS-PAGE, BCA, HPLC/UPLC, and UV-vis. Identify and validate novel therapeutic targets to expand our FORCE platform Communicate experimental results to a diverse audience of scientific collaborators Help maintain a high-functioning laboratory environment Contribute to critical discussions of therapeutic structure, activity, and function Contribute to building a positive, team-oriented culture Education and Skills Requirements: A master's degree in biology, chemistry, or biochemistry with 3+ years of hands-on industry experience, or a BS with 5+ years of experience in early drug discovery and development, is required Skills with chromatographic separation are essential (e.g. SEC, HIC, IEX) Skills with protein assays are also essential (e.g. ELISA, BCA, SDS-PAGE) Skills with analytical methods are a plus (e.g. HPLC, UPLC, LC-MS) Experience with protein bioconjugation, antibody-drug conjugates (ADCs) or antibody-oligonucleotide conjugates is a plus Strong organizational skills and attention to detail Ability to effectively communicate ideas and document research Experienced in software applications (Prism, Excel, PowerPoint)
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. #J-18808-Ljbffr
Dyne Therapeutics is discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. For more information, please visit
Dyne Therapeutics .
Role Summary:
Dyne is seeking a talented and highly motivated Senior Research Associate with a background in biology, chemistry, or biochemistry to help our Bioconjugation team advance therapeutics research and support drug discovery programs. This team member will collaborate closely with in vitro/in vivo biology colleagues to generate and characterize research materials and will also help establish and contribute to the operations of our laboratories.
The ideal candidate is a highly motivated individual with exceptional communication and collaboration skills. The qualified candidate will have the opportunity to build, contribute to, and expand our innovative platform technology and advance Dyne's mission of pioneering life-transforming therapies for patients with serious muscle diseases.
This role is based in Waltham, MA without the possibility of being fully remote.
Primary Responsibilities Include: Generate research therapeutic candidates for in vitro and in vivo studies Design, optimize and execute protein bioconjugation reactions with multiple proteins and payloads ranging from milligram to gram scale Utilize AKTA systems to perform purifications on raw materials and conjugates using a variety of chromatography techniques (IEX, HIC, CHT, etc.) Perform Tangential Flow Filtration (TFF; UF/DF) from milliliter to multi-Liter scale Write technical reports to support technical transfers Analyze the stability of therapeutic materials Perform biochemical analysis on in-process and final purified conjugates- including, but not limited to, the following techniques: Mass Spectrometry (LC-MS), SDS-PAGE, BCA, HPLC/UPLC, and UV-vis. Identify and validate novel therapeutic targets to expand our FORCE platform Communicate experimental results to a diverse audience of scientific collaborators Help maintain a high-functioning laboratory environment Contribute to critical discussions of therapeutic structure, activity, and function Contribute to building a positive, team-oriented culture Education and Skills Requirements: A master's degree in biology, chemistry, or biochemistry with 3+ years of hands-on industry experience, or a BS with 5+ years of experience in early drug discovery and development, is required Skills with chromatographic separation are essential (e.g. SEC, HIC, IEX) Skills with protein assays are also essential (e.g. ELISA, BCA, SDS-PAGE) Skills with analytical methods are a plus (e.g. HPLC, UPLC, LC-MS) Experience with protein bioconjugation, antibody-drug conjugates (ADCs) or antibody-oligonucleotide conjugates is a plus Strong organizational skills and attention to detail Ability to effectively communicate ideas and document research Experienced in software applications (Prism, Excel, PowerPoint)
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. #J-18808-Ljbffr