Merck Gruppe
Principal Scientist, Chemistry Automation
Merck Gruppe - Billerica, Massachusetts, us, 01821
Work at Merck Gruppe
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Overview
Principal Scientist, Automation Chemist
Location:
Billerica, MA By unlocking the power of data AI for drug discovery (AIDD) has the potential to enable personalized medicine and change patient lives. An M-Ventures funded biotech start-up is poised to seize the opportunity at the intersection between the Healthcare and Life Science Divisions of Merck, KGaA Darmstadt, Germany. Our mandate is to think big and reach across teams to leverage the full capabilities of the organization. For more than 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others. Your Role: As a Principal Scientist, Chemistry Automation, you will be part of the Drug Discovery Automation group responsible for designing, managing, and leading the automated chemistry synthesis systems, part of our cutting-edge cloud lab infrastructure providing drug discovery and chemistry services to Pharmaceutical and Biotech customers. The ideal candidate will have a strong background in organic chemistry and experience developing and implementing automated chemistry synthesis systems and processes in pharmaceutical R&D settings. You will be responsible to: Assist in the design, development, and implementation of new automated, high throughput chemistry synthesis systems for medicinal chemistry applications. Transfer chemical synthesis procedure into automated chemistry protocols, troubleshoot and optimize new synthetic methodologies in line with project chemistry requirements. Plan and execute experiments to optimize the efficiency and reproducibility of chemistry synthesis systems, purification and characterization of intermediates and final compounds. Collaborate with cross-functional teams, including process engineers and software developers, procurement, sourcing, facilities, and project management. Develop and implement quality control procedures to ensure that chemistry synthesis processes are carried out accurately and consistently. Execute automation project planning, timeline, milestones, success criteria and resources management including engineers, equipment, lab space etc. for new lab build-outs. Adhere to laboratory's budget, ensuring that all expenditures are justified and aligned with the laboratory's goals and objectives. Prepare and present technical reports, research findings, and presentations to internal and external stakeholders. Location:
Billerica, MA; Hybrid flexibility Travel:
Who You Are: Minimum Qualifications: MS degree in organic chemistry, medicinal chemistry, chemical engineering or related field At least 5 years of relevant experience in small molecule synthesis and chemistry automation in the pharmaceutical/biotech industry Hands-on experience in automated synthesis workflows, including solid/liquid handling platforms, automated reaction execution tools and purification solutions. Knowledge of analytical instrumentations such as HPLC/MS, SFC/MS, with the ability to develop creative solutions to complex chemistry synthesis challenges. Excellent communication and interpersonal skills, with the ability to work effectively with customers, suppliers, and other stakeholders. Preferred Qualifications: PhD Degree in organic chemistry, medicinal chemistry, chemical engineering or related field Strong experience in implementing automated chemistry synthesis processes, including the use of robotic systems. Detailed knowledge of scheduling software design and integration across an automated laboratory environment. Experience with automation project development from concept, preliminary and final design, through construction, installation and project closure strongly preferred with cost analysis. Comfortable working in an entrepreneurial environment, agile and fast-paced teams Self-driven, results-oriented leader with proven collaborative working style
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Billerica, MA By unlocking the power of data AI for drug discovery (AIDD) has the potential to enable personalized medicine and change patient lives. An M-Ventures funded biotech start-up is poised to seize the opportunity at the intersection between the Healthcare and Life Science Divisions of Merck, KGaA Darmstadt, Germany. Our mandate is to think big and reach across teams to leverage the full capabilities of the organization. For more than 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others. Your Role: As a Principal Scientist, Chemistry Automation, you will be part of the Drug Discovery Automation group responsible for designing, managing, and leading the automated chemistry synthesis systems, part of our cutting-edge cloud lab infrastructure providing drug discovery and chemistry services to Pharmaceutical and Biotech customers. The ideal candidate will have a strong background in organic chemistry and experience developing and implementing automated chemistry synthesis systems and processes in pharmaceutical R&D settings. You will be responsible to: Assist in the design, development, and implementation of new automated, high throughput chemistry synthesis systems for medicinal chemistry applications. Transfer chemical synthesis procedure into automated chemistry protocols, troubleshoot and optimize new synthetic methodologies in line with project chemistry requirements. Plan and execute experiments to optimize the efficiency and reproducibility of chemistry synthesis systems, purification and characterization of intermediates and final compounds. Collaborate with cross-functional teams, including process engineers and software developers, procurement, sourcing, facilities, and project management. Develop and implement quality control procedures to ensure that chemistry synthesis processes are carried out accurately and consistently. Execute automation project planning, timeline, milestones, success criteria and resources management including engineers, equipment, lab space etc. for new lab build-outs. Adhere to laboratory's budget, ensuring that all expenditures are justified and aligned with the laboratory's goals and objectives. Prepare and present technical reports, research findings, and presentations to internal and external stakeholders. Location:
Billerica, MA; Hybrid flexibility Travel:
Who You Are: Minimum Qualifications: MS degree in organic chemistry, medicinal chemistry, chemical engineering or related field At least 5 years of relevant experience in small molecule synthesis and chemistry automation in the pharmaceutical/biotech industry Hands-on experience in automated synthesis workflows, including solid/liquid handling platforms, automated reaction execution tools and purification solutions. Knowledge of analytical instrumentations such as HPLC/MS, SFC/MS, with the ability to develop creative solutions to complex chemistry synthesis challenges. Excellent communication and interpersonal skills, with the ability to work effectively with customers, suppliers, and other stakeholders. Preferred Qualifications: PhD Degree in organic chemistry, medicinal chemistry, chemical engineering or related field Strong experience in implementing automated chemistry synthesis processes, including the use of robotic systems. Detailed knowledge of scheduling software design and integration across an automated laboratory environment. Experience with automation project development from concept, preliminary and final design, through construction, installation and project closure strongly preferred with cost analysis. Comfortable working in an entrepreneurial environment, agile and fast-paced teams Self-driven, results-oriented leader with proven collaborative working style
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