Z-Alpha Therapeutics
Principal Scientist, Medicinal Chemistry - Peptides (Must Have 5+...
Z-Alpha Therapeutics - Durham, North Carolina, United States, 27703
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Principal Scientist, Medicinal Chemistry - Peptides (Must Have 5+ Yrs Industry Exp), Small Molecule, Cancer
Principal Scientist, Medicinal Chemistry - Peptides (Must Have 5+ Yrs Industry Exp), Small Molecule, Cancer
1 week ago Be among the first 25 applicants Get AI-powered advice on this job and more exclusive features. MUST HAVE 5+ YEARS RELATED INDUSTRY EXPERIENCE About Us : Z-Alpha Therapeutics is a pharmaceutical company dedicated to the discovery and development of radiotherapeutics targeting key biological pathways for solid tumors. The company has a revolutionary technology platform in the next generation of alpha particle therapy with potential to be a more targeted therapy, increasing efficacy and limiting toxicity compared to competitors in the radiotherapeutics space. The company has a world-class team of scientists with decades of experience and foundational intellectual property that enables the potential to bring multiple drug candidates into the clinic. Position Overview : We are looking for a highly experienced and innovative Principal Scientist in Chemistry to lead our drug discovery efforts. The ideal candidate will possess extensive expertise in medicinal chemistry and a proven ability to drive projects from early discovery through preclinical development. This position requires strong leadership, strategic insight, and effective collaboration across multidisciplinary teams. Key Responsibilities: Lead and oversee the design, synthesis, and optimization of small molecule drug candidates. Develop and implement medicinal chemistry strategies to enhance the drug discovery pipeline. Collaborate closely with cross-functional teams, including biology, pharmacology, and toxicology, to advance projects. Utilize structure-activity relationship (SAR) studies to inform and guide compound optimization. Up to 50% lab work is expected. Analyze complex datasets, interpret experimental outcomes, and present findings at project team and company-wide meetings. Maintain rigorous records of experiments, ensuring data integrity, reproducibility, and adherence to regulatory standards. Provide scientific guidance and mentorship to junior team members, fostering a collaborative and innovative research environment. Establish and manage laboratory infrastructure and standard operation process. Stay abreast of industry trends and advancements in medicinal chemistry to inform project strategies. Qualifications: Ph.D. in Organic Chemistry or a related field with
5+ years of relevant industry experience. Expertise in modern synthetic organic chemistry, with proficiency in multi-step syntheses and retrosynthetic analysis of complex molecules. Demonstrated ability to creatively employ structure- and/or ligand-based drug design to enhance the potency of lead compounds. Extensive knowledge of medicinal chemistry principles with proven track record of leading drug discovery projects with successful outcomes. Highly organized, with strong time-management skills and the ability to adapt to rapidly changing project landscapes. Collaborative team player with the ability to work independently and manage competing priorities effectively. Experience with interacting with external chemistry vendors. Excellent communication and leadership skills' Join us at Z-Alpha Therapeutics and contribute to innovative solutions that redefine the landscape of cancer treatment! Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
Job function Science, Research, and Project Management Industries Biotechnology Research and Pharmaceutical Manufacturing Referrals increase your chances of interviewing at Z-Alpha Therapeutics by 2x Get notified about new Chemist jobs in
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Principal Scientist, Medicinal Chemistry - Peptides (Must Have 5+ Yrs Industry Exp), Small Molecule, Cancer
1 week ago Be among the first 25 applicants Get AI-powered advice on this job and more exclusive features. MUST HAVE 5+ YEARS RELATED INDUSTRY EXPERIENCE About Us : Z-Alpha Therapeutics is a pharmaceutical company dedicated to the discovery and development of radiotherapeutics targeting key biological pathways for solid tumors. The company has a revolutionary technology platform in the next generation of alpha particle therapy with potential to be a more targeted therapy, increasing efficacy and limiting toxicity compared to competitors in the radiotherapeutics space. The company has a world-class team of scientists with decades of experience and foundational intellectual property that enables the potential to bring multiple drug candidates into the clinic. Position Overview : We are looking for a highly experienced and innovative Principal Scientist in Chemistry to lead our drug discovery efforts. The ideal candidate will possess extensive expertise in medicinal chemistry and a proven ability to drive projects from early discovery through preclinical development. This position requires strong leadership, strategic insight, and effective collaboration across multidisciplinary teams. Key Responsibilities: Lead and oversee the design, synthesis, and optimization of small molecule drug candidates. Develop and implement medicinal chemistry strategies to enhance the drug discovery pipeline. Collaborate closely with cross-functional teams, including biology, pharmacology, and toxicology, to advance projects. Utilize structure-activity relationship (SAR) studies to inform and guide compound optimization. Up to 50% lab work is expected. Analyze complex datasets, interpret experimental outcomes, and present findings at project team and company-wide meetings. Maintain rigorous records of experiments, ensuring data integrity, reproducibility, and adherence to regulatory standards. Provide scientific guidance and mentorship to junior team members, fostering a collaborative and innovative research environment. Establish and manage laboratory infrastructure and standard operation process. Stay abreast of industry trends and advancements in medicinal chemistry to inform project strategies. Qualifications: Ph.D. in Organic Chemistry or a related field with
5+ years of relevant industry experience. Expertise in modern synthetic organic chemistry, with proficiency in multi-step syntheses and retrosynthetic analysis of complex molecules. Demonstrated ability to creatively employ structure- and/or ligand-based drug design to enhance the potency of lead compounds. Extensive knowledge of medicinal chemistry principles with proven track record of leading drug discovery projects with successful outcomes. Highly organized, with strong time-management skills and the ability to adapt to rapidly changing project landscapes. Collaborative team player with the ability to work independently and manage competing priorities effectively. Experience with interacting with external chemistry vendors. Excellent communication and leadership skills' Join us at Z-Alpha Therapeutics and contribute to innovative solutions that redefine the landscape of cancer treatment! Seniority level
Seniority level Mid-Senior level Employment type
Employment type Full-time Job function
Job function Science, Research, and Project Management Industries Biotechnology Research and Pharmaceutical Manufacturing Referrals increase your chances of interviewing at Z-Alpha Therapeutics by 2x Get notified about new Chemist jobs in
Durham, NC . Entry Level Engineers/Scientists/Chemists/Technicians
Entry Level Engineers/Scientists/Chemists/Technicians
Triangle, NC $55,000.00-$72,000.00 1 month ago Entry Level Engineers/Scientists/Chemists/Technicians
Raleigh, NC $55,000.00-$72,000.00 1 month ago Entry Level Engineers/Scientists/Chemists/Technicians
Chapel Hill, NC $55,000.00-$72,000.00 1 month ago Triangle, NC $80,000.00-$120,000.00 1 month ago Chapel Hill, NC $80,000.00-$120,000.00 1 month ago Raleigh, NC $80,000.00-$120,000.00 1 month ago Chemist/ASC Enviromental, Health and Safety Administrator
Scientist 2 - Polymer Scientist (Research Exp is Required)
Research and Development Chemist- AI Trainer
Scientist 1, Analytical Chemistry Development
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Chapel Hill, NC $55,000.00-$80,000.00 1 month ago Raleigh, NC $55,000.00-$80,000.00 1 month ago Scientist 1, Analytical Chemistry Development
Materials Scientist [Must Have synthetic chemistry] - Urgent Need
Scientist 2, Analytical Chemistry Development
Formulation Scientist [Must Have Drug delivery principle] - Urgent Need
Post-Doc Research Associate (Synthetic Chemistry -Heterocycles) - Frankowski Lab
We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr