Flagship Pioneering
FL87 | Cambridge, MA Senior Scientist, Histology and Bioanalytics
Flagship Pioneering, Cambridge, Massachusetts, us, 02140
Senior Scientist, Histology and Bioanalytics
Cambridge, MA USACompany Summary:FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.FL87 was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.Position Summary:We are searching for an experienced Senior Scientist to lead histology and related bioanalytics for platform development and therapeutic proof-of-principle. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment, working both independently and as part of a highly collaborative and rapidly growing team.Key Responsibilities:Drive the execution and analysis of bioanalytics to assess efficacy, safety and biodistribution of novel nucleic acid therapeutics.Develop and execute histology multiplexed IHC/IF and RNAscope mixed modality methods including slide imaging and image analysis.Extensive experience with assay development, qualification, and validation: Flow cytometry, qPCR, MSD, ELISA, other relevant analytics.Determine nucleic acid pharmacology at the tissue level, including developing preclinical datasets to drive mechanistic understanding of delivery and function.Provide scientific and technical perspectives to advance platform development.Effectively communicate experimental findings in oral, written, and visual formats.Work independently and collaboratively in a multidisciplinary team environment.Qualifications:PhD in relevant discipline or BS in relevant disciple with 7+ years of industry experience. Level will be based on experience.Deep expertise with histological tissue analysis (IHC/IF, ISH, H&E, etc.) including tissue harvest, embedding, sectioning, staining, imaging and image analysis.Experience with
in vivo
studies, ideally involving non-viral delivery and/or nucleic acid based therapeutics in rat, mouse, and NHP.Experience working in-house and with external partners/CROs to execute studies and develop new capabilities.Experience with tissue processing and
ex vivo
analytical assays such as ELISA, FACS, MSD, qPCR, etc.Experience with various mouse and rat models of diseases is a plus.Strong communication and interpersonal skills.Strong organizational, analytical, and problem-solving skills.Ability to thrive in a fast-paced, multidisciplinary, and rapidly growing biotech environment.At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
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Cambridge, MA USACompany Summary:FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.FL87 was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.Position Summary:We are searching for an experienced Senior Scientist to lead histology and related bioanalytics for platform development and therapeutic proof-of-principle. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment, working both independently and as part of a highly collaborative and rapidly growing team.Key Responsibilities:Drive the execution and analysis of bioanalytics to assess efficacy, safety and biodistribution of novel nucleic acid therapeutics.Develop and execute histology multiplexed IHC/IF and RNAscope mixed modality methods including slide imaging and image analysis.Extensive experience with assay development, qualification, and validation: Flow cytometry, qPCR, MSD, ELISA, other relevant analytics.Determine nucleic acid pharmacology at the tissue level, including developing preclinical datasets to drive mechanistic understanding of delivery and function.Provide scientific and technical perspectives to advance platform development.Effectively communicate experimental findings in oral, written, and visual formats.Work independently and collaboratively in a multidisciplinary team environment.Qualifications:PhD in relevant discipline or BS in relevant disciple with 7+ years of industry experience. Level will be based on experience.Deep expertise with histological tissue analysis (IHC/IF, ISH, H&E, etc.) including tissue harvest, embedding, sectioning, staining, imaging and image analysis.Experience with
in vivo
studies, ideally involving non-viral delivery and/or nucleic acid based therapeutics in rat, mouse, and NHP.Experience working in-house and with external partners/CROs to execute studies and develop new capabilities.Experience with tissue processing and
ex vivo
analytical assays such as ELISA, FACS, MSD, qPCR, etc.Experience with various mouse and rat models of diseases is a plus.Strong communication and interpersonal skills.Strong organizational, analytical, and problem-solving skills.Ability to thrive in a fast-paced, multidisciplinary, and rapidly growing biotech environment.At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
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