Senior Scientist, Histology and Bioanalytics

Company Summary:FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.FL87 was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.Position Summary:We are searching for an experienced Senior Scientist to lead histology and related bioanalytics for platform development and therapeutic proof-of-principle. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment, working both independently and as part of a highly collaborative and rapidly growing team.Key Responsibilities:Drive the execution and analysis of bioanalytics to assess efficacy, safety and biodistribution of novel nucleic acid therapeutics.Develop and execute histology multiplexed IHC/IF and RNAscope mixed modality methods including slide imaging and image analysis.Extensive experience with assay development, qualification, and validation: Flow cytometry, qPCR, MSD, ELISA, other relevant analytics.Determine nucleic acid pharmacology at the tissue level, including developing preclinical datasets to drive mechanistic understanding of delivery and function.Provide scientific and technical perspectives to advance platform development.Effectively communicate experimental findings in oral, written, and visual formats.Work independently and collaboratively in a multidisciplinary team environment.Qualifications:PhD in relevant discipline or BS in relevant discipline with 7+ years of industry experience.Deep expertise with histological tissue analysis (IHC/IF, ISH, H&E, etc.) including tissue harvest, embedding, sectioning, staining, imaging and image analysis.Experience with in vivo studies, ideally involving non-viral delivery and/or nucleic acid based therapeutics in rat, mouse, and NHP.Experience working in-house and with external partners/CROs to execute studies and develop new capabilities.Experience with tissue processing and ex vivo analytical assays such as ELISA, FACS, MSD, qPCR, etc.Experience with various mouse and rat models of diseases is a plus.Experience performing in vivo procedures in rodents, including preparation and administration of therapeutics and collecting material (blood, tissue, etc.) for ex vivo analysis is a plus.Strong communication and interpersonal skills.Strong organizational, analytical, and problem-solving skills.Ability to thrive in a fast-paced, multidisciplinary, and rapidly growing biotech environment.Equal Employment Opportunity:

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.Recruitment & Staffing Agencies:

Flagship Pioneering and its affiliated Flagship Lab companies do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited.

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