St. Jude Children's Research Hospital (St. Jude)
Scientist (GPCR) - Protein Technologies Center
St. Jude Children's Research Hospital (St. Jude), Memphis, Tennessee, us, 37544
We are seeking a Scientist with experience in protein and membrane protein biochemistry to join a newly funded GPCR collaborative project.
JOB SUMMARY:
The Protein Technologies Center (PTC) in the Department of Structural Biology is seeking a highly motivated Scientist with experience in protein and membrane protein biochemistry to join a newly funded GPCR collaborative project to investigate the molecular determinants and fidelity of GPCR signaling in health and disease. As part of the collaborative grant, the candidate will work closely with several partnering labs (Scott Blanchard, Madan Babu, Robert Lefkowitz, Alice Ting, Jonathan Javitch, and Georgios Skiniotis).
Successful candidates should have demonstrated competencies in the following areas:
Cloning, expression, purification, and biochemically characterizing membrane proteins from mammalian and/or insect cell systems.
Prior experience with membrane protein or GPCR structural studies or functional assays.
A significant contribution towards peer-reviewed research articles in the related scientific subject(s).
Excellent record-keeping, communication, and presentation skills and ability to prepare high-quality manuscripts of findings for publication.
Responsibilities:
Design constructs, clone, express, and purify GPCRs, G-proteins, arrestins, and other signaling proteins for structural, functional, and biophysical experiments to investigate structure-dynamics-function relationships.
Structure determination using either CryoEM or x-ray methods.
Work independently, leading a project from hypothesis to high-quality oral presentations and publications.
Collaborate with an interdisciplinary group of researchers as part of a multi-institutional collaborative, including presentations to a broad audience.
Train and mentor graduate students, post-docs, and visiting scientists.
Instruct other staff in basic laboratory techniques and procedures.
Minimum Education and/or Training:
Bachelor's degree in relevant scientific area is required.
Ph.D. in molecular biology, biochemistry, protein engineering, or any related discipline preferred.
Minimum Experience:
Seven (7) years of relevant post-degree work experience is required with a Bachelor's degree.
Five (5) years of relevant post-degree work experience is required with a Master's degree.
Three (3) years of relevant post-degree work experience is required with a PhD.
Compensation:
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Scientist (GPCR) - Protein Technologies Center.
Explore our exceptional benefits!
Diversity, Equity and Inclusion:
St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment.
St. Jude is an Equal Opportunity Employer
No Search Firms:
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email.
#J-18808-Ljbffr
JOB SUMMARY:
The Protein Technologies Center (PTC) in the Department of Structural Biology is seeking a highly motivated Scientist with experience in protein and membrane protein biochemistry to join a newly funded GPCR collaborative project to investigate the molecular determinants and fidelity of GPCR signaling in health and disease. As part of the collaborative grant, the candidate will work closely with several partnering labs (Scott Blanchard, Madan Babu, Robert Lefkowitz, Alice Ting, Jonathan Javitch, and Georgios Skiniotis).
Successful candidates should have demonstrated competencies in the following areas:
Cloning, expression, purification, and biochemically characterizing membrane proteins from mammalian and/or insect cell systems.
Prior experience with membrane protein or GPCR structural studies or functional assays.
A significant contribution towards peer-reviewed research articles in the related scientific subject(s).
Excellent record-keeping, communication, and presentation skills and ability to prepare high-quality manuscripts of findings for publication.
Responsibilities:
Design constructs, clone, express, and purify GPCRs, G-proteins, arrestins, and other signaling proteins for structural, functional, and biophysical experiments to investigate structure-dynamics-function relationships.
Structure determination using either CryoEM or x-ray methods.
Work independently, leading a project from hypothesis to high-quality oral presentations and publications.
Collaborate with an interdisciplinary group of researchers as part of a multi-institutional collaborative, including presentations to a broad audience.
Train and mentor graduate students, post-docs, and visiting scientists.
Instruct other staff in basic laboratory techniques and procedures.
Minimum Education and/or Training:
Bachelor's degree in relevant scientific area is required.
Ph.D. in molecular biology, biochemistry, protein engineering, or any related discipline preferred.
Minimum Experience:
Seven (7) years of relevant post-degree work experience is required with a Bachelor's degree.
Five (5) years of relevant post-degree work experience is required with a Master's degree.
Three (3) years of relevant post-degree work experience is required with a PhD.
Compensation:
In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Scientist (GPCR) - Protein Technologies Center.
Explore our exceptional benefits!
Diversity, Equity and Inclusion:
St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment.
St. Jude is an Equal Opportunity Employer
No Search Firms:
St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email.
#J-18808-Ljbffr