Quadram Institute
Research Scientist
Quadram Institute, Jackson, Mississippi, United States,
Hours per week: 37Project Title: The impact of an innovative freeze-dried fermented coconut-based ingredient on the gut microbiota - microbial metabolites, gut bacterial composition and survival of probiotic lactobacilliExpected/Ideal Start Date: 18 Nov 2024Months Duration: 6Interview Date: 01 Nov 2024Job Description
Main Purpose of the Job
We are looking to hire a Research Scientist to work on a recently awarded BBSRC grant through the RIPEN hub in collaboration with a food company, Fermenti Foods. This exciting collaborative project will involve testing the pre-and probiotic potential of novel fermented food products developed by Fermenti Foods in advanced in vitro simulations of the human digestive tract and microbial environment available at Quadram.The project aims to understand the survival of the probiotic bacteria in a food matrix through the GI tract, and the implications of these probiotics in combination with prebiotic fibres on the microbial community of the gut and metabolic consequences.Key activities will involve testing novel fermented fibre formulations in conjunction with the start-up company. This will involve carrying out in vitro digestions using INFOGEST 2.0 and model gut fermentations of the formulations and analysing the impact on the gut microbiome through metagenomic analysis of microbial communities, metabolomics, and analysis of volatile metabolites.The analysis will be supported by the sequencing, metabolomics, and bioinformatics platforms available at Quadram Institute.Key Relationships
The position will report to Dr Fred Warren who will be the project coordinator at Quadram. The post holder will also need to work closely with other researchers within the Warren Group, as well as other teams in the Institute including core sequencing, bioinformatics, and metabolomics. Externally, the post holder will need to be in regular contact with representatives from the industrial partner, food technologists, and the funder, RIPEN hub, to update on progress and coordinate research.Main Activities & Responsibilities
Percentage• INFOGEST digestions, model colon experiments, metagenomics, and metabolomics: 60%• Data analysis and bioinformatics: 15%• Collaborating with project partners, preparing reports for funders: 10%• Ensure research and record keeping is carried out in accordance with good practice, Scientific Integrity and in compliance with local policies and any legal requirements: 5%• Contribute to the smooth running of the group, including the effective use of resources, supervision of visitors to the laboratory and assisting with training others, encouraging scientific excellence: 5%• Continually strive for excellence, seeking out and acting on feedback and relevant learning and development opportunities: 5%• As agreed with line manager, any other duties commensurate with the nature of the role.Person Profile
Education & Qualifications
PhD in biochemistry, molecular biology, nutrition, or related discipline: EssentialSpecialist Knowledge & Skills
Metabolomics analysis by NMR or LC-MS: EssentialAnalysis of pre- or probiotics: EssentialDNA extraction and shotgun metagenomics analysis: DesirableExperience with the INFOGEST procedure, or similar in vitro models: DesirableExperience working with in vitro models of the human digestive tract: EssentialWillingness to / experience of handling human samples: EssentialExperience working with industrial partners: EssentialInterpersonal & Communication Skills
Excellent communication skills, both written and oral, including the ability to present complex information with clarity: EssentialExcellent time management and organisational skills with proven ability to meet deadlines: EssentialDemonstrated ability to work independently, using initiative and applying problem solving skills: EssentialEmbrace working as part of a diverse and multi-disciplinary team: EssentialAbility to follow instructions/Standard Operating Procedures: EssentialGood interpersonal skills, with the ability to work as part of a team: EssentialAbility to collaborate with internal and external stakeholders: EssentialPromotes and strives for continuous improvement: EssentialAdditional Requirements
Attention to detail: EssentialPromotes equality and values diversity: EssentialWillingness to work outside standard working hours when required: EssentialWillingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work: EssentialAble to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute: EssentialWho We Are
Quadram Institute Bioscience
The Quadram Institute is at the forefront of a new interface between food science, gut biology, and health, developing solutions to worldwide challenges in food-related disease and human health.We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy, and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team.The post will be based in the Warren group at Quadram. The Warren group focuses on understanding the impact of carbohydrate structure on digestion and the gut microbiome in health and disease. Based within the Food, Microbes, and Health strategic programme at the Quadram Institute, the group aims to leverage expertise in physical chemistry of carbohydrates, advanced gut models, and 'omics technology to develop innovative microbiome targeted foods.Research ScientistApplications are invited for a Research Scientist to join the Laboratory of Dr Warren in the Food, Microbiome and Health programme at Quadram Institute Bioscience (QIB), based in Norwich, UK.Background:The post will be based in the Warren Group at Quadram Institute. The Warren Group focuses on understanding the impact of carbohydrate structure on digestion and the gut microbiome in health and disease. Based within the Food, Microbes, and Health strategic programme at the Quadram Institute, the group aims to leverage expertise in physical chemistry of carbohydrates, advanced gut models, and 'omics technology to develop innovative microbiome targeted foods.The role:We are looking to hire an enthusiastic Research Scientist with a background in dietary fibre, gut health, or gut microbiology to work on a dynamic RIPEN hub project aiming to develop the next generation of novel pro- and prebiotic ingredients. Working with a start-up company, this project will aim to explore the survival of probiotics from innovative fermented food ingredients through a simulated GIT tract.We will aim to explore the impact of formulations on gut microbiome composition, the abundance of beneficial microbes, and microbial metabolites. This will be achieved using the cutting-edge model gut systems available at Quadram Institute, combined with cutting-edge omics technologies.There will be the potential to see discoveries rapidly translated into real world applications.The ideal candidate:The successful candidate will have a PhD in biochemistry, molecular biology, nutrition, or a related discipline. Previous experience working with in vitro gut models, pre and probiotics, and the gut microbiome is essential, and experience working with industrial partners would be advantageous.Strong organisational and communication skills and the ability to work independently will be essential for this fast-paced industry-partnered project.Additional information:Salary on appointment will be within the range £36,720 to £39,750 per annum depending on qualifications and experience. This is a full-time post for a contract of 6 months.This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options.Interviews will be held on 1 November 2024.We are committed to equal opportunities and welcome applications from all sectors of society. The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values. To support our commitment, we have a range of family, faith, and diversity friendly working arrangements to help all staff achieve excellence in their area of work.As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.About the Quadram Institute:The Quadram Institute is a new interdisciplinary research institute dedicated to understanding how food and microbes interact to promote health and prevent disease. Its mission is to deliver healthier lives through innovation in gut health, microbiology, and food. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital, and BBSRC, it brings together scientists and clinicians in a state-of-the-art building on the Norwich Research Park.The closing date for applications will be 24 October 2024.The Quadram Institute Bioscience is a registered charity (No. 1058499) and is an Equal Opportunities Employer.
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Main Purpose of the Job
We are looking to hire a Research Scientist to work on a recently awarded BBSRC grant through the RIPEN hub in collaboration with a food company, Fermenti Foods. This exciting collaborative project will involve testing the pre-and probiotic potential of novel fermented food products developed by Fermenti Foods in advanced in vitro simulations of the human digestive tract and microbial environment available at Quadram.The project aims to understand the survival of the probiotic bacteria in a food matrix through the GI tract, and the implications of these probiotics in combination with prebiotic fibres on the microbial community of the gut and metabolic consequences.Key activities will involve testing novel fermented fibre formulations in conjunction with the start-up company. This will involve carrying out in vitro digestions using INFOGEST 2.0 and model gut fermentations of the formulations and analysing the impact on the gut microbiome through metagenomic analysis of microbial communities, metabolomics, and analysis of volatile metabolites.The analysis will be supported by the sequencing, metabolomics, and bioinformatics platforms available at Quadram Institute.Key Relationships
The position will report to Dr Fred Warren who will be the project coordinator at Quadram. The post holder will also need to work closely with other researchers within the Warren Group, as well as other teams in the Institute including core sequencing, bioinformatics, and metabolomics. Externally, the post holder will need to be in regular contact with representatives from the industrial partner, food technologists, and the funder, RIPEN hub, to update on progress and coordinate research.Main Activities & Responsibilities
Percentage• INFOGEST digestions, model colon experiments, metagenomics, and metabolomics: 60%• Data analysis and bioinformatics: 15%• Collaborating with project partners, preparing reports for funders: 10%• Ensure research and record keeping is carried out in accordance with good practice, Scientific Integrity and in compliance with local policies and any legal requirements: 5%• Contribute to the smooth running of the group, including the effective use of resources, supervision of visitors to the laboratory and assisting with training others, encouraging scientific excellence: 5%• Continually strive for excellence, seeking out and acting on feedback and relevant learning and development opportunities: 5%• As agreed with line manager, any other duties commensurate with the nature of the role.Person Profile
Education & Qualifications
PhD in biochemistry, molecular biology, nutrition, or related discipline: EssentialSpecialist Knowledge & Skills
Metabolomics analysis by NMR or LC-MS: EssentialAnalysis of pre- or probiotics: EssentialDNA extraction and shotgun metagenomics analysis: DesirableExperience with the INFOGEST procedure, or similar in vitro models: DesirableExperience working with in vitro models of the human digestive tract: EssentialWillingness to / experience of handling human samples: EssentialExperience working with industrial partners: EssentialInterpersonal & Communication Skills
Excellent communication skills, both written and oral, including the ability to present complex information with clarity: EssentialExcellent time management and organisational skills with proven ability to meet deadlines: EssentialDemonstrated ability to work independently, using initiative and applying problem solving skills: EssentialEmbrace working as part of a diverse and multi-disciplinary team: EssentialAbility to follow instructions/Standard Operating Procedures: EssentialGood interpersonal skills, with the ability to work as part of a team: EssentialAbility to collaborate with internal and external stakeholders: EssentialPromotes and strives for continuous improvement: EssentialAdditional Requirements
Attention to detail: EssentialPromotes equality and values diversity: EssentialWillingness to work outside standard working hours when required: EssentialWillingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work: EssentialAble to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute: EssentialWho We Are
Quadram Institute Bioscience
The Quadram Institute is at the forefront of a new interface between food science, gut biology, and health, developing solutions to worldwide challenges in food-related disease and human health.We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy, and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation.The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team.The post will be based in the Warren group at Quadram. The Warren group focuses on understanding the impact of carbohydrate structure on digestion and the gut microbiome in health and disease. Based within the Food, Microbes, and Health strategic programme at the Quadram Institute, the group aims to leverage expertise in physical chemistry of carbohydrates, advanced gut models, and 'omics technology to develop innovative microbiome targeted foods.Research ScientistApplications are invited for a Research Scientist to join the Laboratory of Dr Warren in the Food, Microbiome and Health programme at Quadram Institute Bioscience (QIB), based in Norwich, UK.Background:The post will be based in the Warren Group at Quadram Institute. The Warren Group focuses on understanding the impact of carbohydrate structure on digestion and the gut microbiome in health and disease. Based within the Food, Microbes, and Health strategic programme at the Quadram Institute, the group aims to leverage expertise in physical chemistry of carbohydrates, advanced gut models, and 'omics technology to develop innovative microbiome targeted foods.The role:We are looking to hire an enthusiastic Research Scientist with a background in dietary fibre, gut health, or gut microbiology to work on a dynamic RIPEN hub project aiming to develop the next generation of novel pro- and prebiotic ingredients. Working with a start-up company, this project will aim to explore the survival of probiotics from innovative fermented food ingredients through a simulated GIT tract.We will aim to explore the impact of formulations on gut microbiome composition, the abundance of beneficial microbes, and microbial metabolites. This will be achieved using the cutting-edge model gut systems available at Quadram Institute, combined with cutting-edge omics technologies.There will be the potential to see discoveries rapidly translated into real world applications.The ideal candidate:The successful candidate will have a PhD in biochemistry, molecular biology, nutrition, or a related discipline. Previous experience working with in vitro gut models, pre and probiotics, and the gut microbiome is essential, and experience working with industrial partners would be advantageous.Strong organisational and communication skills and the ability to work independently will be essential for this fast-paced industry-partnered project.Additional information:Salary on appointment will be within the range £36,720 to £39,750 per annum depending on qualifications and experience. This is a full-time post for a contract of 6 months.This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options.Interviews will be held on 1 November 2024.We are committed to equal opportunities and welcome applications from all sectors of society. The Institute supports equality of opportunity within the workplace and expects all employees to share and display these values. To support our commitment, we have a range of family, faith, and diversity friendly working arrangements to help all staff achieve excellence in their area of work.As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.About the Quadram Institute:The Quadram Institute is a new interdisciplinary research institute dedicated to understanding how food and microbes interact to promote health and prevent disease. Its mission is to deliver healthier lives through innovation in gut health, microbiology, and food. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital, and BBSRC, it brings together scientists and clinicians in a state-of-the-art building on the Norwich Research Park.The closing date for applications will be 24 October 2024.The Quadram Institute Bioscience is a registered charity (No. 1058499) and is an Equal Opportunities Employer.
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