Immunome, Inc.
Senior Director, Head of Antibody Conjugation Development
Immunome, Inc., Bothell, Washington, United States, 98021
Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) In addition to a portfolio of discovery-stage ADCs, our pipeline includes AL102, a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, as well as IM-1021, a ROR1 ADC, and IM-3050, a FAP-targeted radioligand, both of which are the subject of INDs expected to be submitted in the first quarter of 2025.
Position Overview
We are seeking a highly experienced and motivated individual to lead our Antibody Conjugation Development team. As the Head of Antibody Conjugation Development, you will be responsible for overseeing the development and optimization of antibody-drug conjugates (ADCs). You will play a key role in the strategic direction, planning, and execution of projects related to antibody conjugation, ensuring that they meet both scientific and regulatory standards
Responsibilities
Lead the antibody conjugation development team to design and optimize conjugation strategies for antibody-drug conjugates (ADCs)
Oversee the development, scale-up, and transfer of conjugation processes to ensure robust and reproducible manufacturing processes.
Drive innovation in conjugation technologies to improve conjugation specificity and efficiency to deliver safe and efficacious drug substances.
Collaborate with cross-functional teams, including Analytical Development, mAb Process Development, Manufacturing, and Quality, to ensure seamless integration of conjugation strategies across all phases of development.
Lead troubleshooting and process optimization efforts to resolve technical challenges related to conjugation, stability, and scalability.
Generate suitable materials to support IND-enabling toxicology studies
Manage the preparation of technical reports, documentation, and regulatory submissions to support clinical development and commercialization.
Stay current with industry trends, technologies, and regulatory requirements for antibody conjugation and bioconjugates.
Mentor, develop, and manage a team of scientists, ensuring high performance and professional growth.
Collaborate with external partners, contract development and manufacturing organizations (CDMOs) to support pipeline development and drive innovation in conjugation technologies.
Qualifications
Ph.D. in Biochemistry, Chemistry, Molecular Biology, Chemical Engineering, or related field, with a focus on antibody conjugation or bioconjugates.
Minimum of 12+ years of relevant experience in the biopharmaceutical industry, specifically in the development of antibody-drug conjugates (ADCs) or other conjugated biotherapeutics. A minimum of 5 years of leadership experience.
Proven track record of leading successful conjugation development projects from early-stage research through late-stage development or commercialization.
Experience working in a GMP environment and a strong understanding of regulatory requirements for bioconjugates.
Excellent leadership, project management, and communication skills.
Knowledge and Skills
In-depth understanding of the critical quality attributes (CQAs) of ADCs and bioconjugates, and experience with process development, scale-up, and tech transfer.
Expertise in linker chemistry, conjugation techniques (e.g., cysteine/lysine conjugation), and bioconjugate characterization methods.
Strong analytical and problem-solving abilities with a focus on innovation and continuous improvement.
Excellent interpersonal skills and ability to work in a multidisciplinary team environment.
Ability to manage multiple projects with tight deadlines and priorities.
Strong strategic planning and decision-making skills.
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
#J-18808-Ljbffr
Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) In addition to a portfolio of discovery-stage ADCs, our pipeline includes AL102, a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, as well as IM-1021, a ROR1 ADC, and IM-3050, a FAP-targeted radioligand, both of which are the subject of INDs expected to be submitted in the first quarter of 2025.
Position Overview
We are seeking a highly experienced and motivated individual to lead our Antibody Conjugation Development team. As the Head of Antibody Conjugation Development, you will be responsible for overseeing the development and optimization of antibody-drug conjugates (ADCs). You will play a key role in the strategic direction, planning, and execution of projects related to antibody conjugation, ensuring that they meet both scientific and regulatory standards
Responsibilities
Lead the antibody conjugation development team to design and optimize conjugation strategies for antibody-drug conjugates (ADCs)
Oversee the development, scale-up, and transfer of conjugation processes to ensure robust and reproducible manufacturing processes.
Drive innovation in conjugation technologies to improve conjugation specificity and efficiency to deliver safe and efficacious drug substances.
Collaborate with cross-functional teams, including Analytical Development, mAb Process Development, Manufacturing, and Quality, to ensure seamless integration of conjugation strategies across all phases of development.
Lead troubleshooting and process optimization efforts to resolve technical challenges related to conjugation, stability, and scalability.
Generate suitable materials to support IND-enabling toxicology studies
Manage the preparation of technical reports, documentation, and regulatory submissions to support clinical development and commercialization.
Stay current with industry trends, technologies, and regulatory requirements for antibody conjugation and bioconjugates.
Mentor, develop, and manage a team of scientists, ensuring high performance and professional growth.
Collaborate with external partners, contract development and manufacturing organizations (CDMOs) to support pipeline development and drive innovation in conjugation technologies.
Qualifications
Ph.D. in Biochemistry, Chemistry, Molecular Biology, Chemical Engineering, or related field, with a focus on antibody conjugation or bioconjugates.
Minimum of 12+ years of relevant experience in the biopharmaceutical industry, specifically in the development of antibody-drug conjugates (ADCs) or other conjugated biotherapeutics. A minimum of 5 years of leadership experience.
Proven track record of leading successful conjugation development projects from early-stage research through late-stage development or commercialization.
Experience working in a GMP environment and a strong understanding of regulatory requirements for bioconjugates.
Excellent leadership, project management, and communication skills.
Knowledge and Skills
In-depth understanding of the critical quality attributes (CQAs) of ADCs and bioconjugates, and experience with process development, scale-up, and tech transfer.
Expertise in linker chemistry, conjugation techniques (e.g., cysteine/lysine conjugation), and bioconjugate characterization methods.
Strong analytical and problem-solving abilities with a focus on innovation and continuous improvement.
Excellent interpersonal skills and ability to work in a multidisciplinary team environment.
Ability to manage multiple projects with tight deadlines and priorities.
Strong strategic planning and decision-making skills.
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
#J-18808-Ljbffr