Bolt Biotherapeutics
Research Associate I/II ~ Bioconjugation
Bolt Biotherapeutics, Redwood City, California, United States, 94061
Who We AreBolt Biotherapeutics, based in the San Francisco Bay Area, is a clinical-stage biotechnology company developing Boltbody Immune-stimulating Antibody Conjugates (ISACs), a new class of immuno-oncology therapeutics. This is a unique opportunity to join and build, with like-minded colleagues, a company that will transform the lives of individuals with cancer.At Bolt Biotherapeutics, we are seeking a highly motivated Research Associate to join our research bioconjugation team. The primary responsibility of the successful candidate is to perform a variety of antibody conjugation chemistries and techniques to support discovery and pipeline programs.Responsibilities:
Perform conjugation (lysine, cysteine, site specific, etc.) of antibodies to diverse linker-payloads on mg to gram scale, following established protocols and procedures.Conduct purification of the antibody drug conjugates utilizing various chromatographic techniques (affinity chromatography, size exclusion chromatography, ion exchange chromatography, membrane filtration (TFF), etc.)Perform analytical characterization of the antibodies and bioconjugates using analytical techniques including UV-Vis, HIC, SEC, RP-HPLC, and LC-MS.Maintain accurate records of experiments, results, and analytical data. Adhere to safety guidelines and protocols in the laboratory environment.Qualifications:
Bachelor's or Master's degree in biochemistry or related discipline with 2+ years of industrial or academic experience in bioconjugation.Hands-on experience with conjugation, purification, and analytical characterization of antibody drug conjugates.Ability to work both independently & collaboratively and willingness to learn new bioconjugation chemistries/techniques.Strong communication skills, collaborative, self-motivated, goal-oriented, and strong teamwork in a fast-paced setting.$60,000 - $85,000 a year
We are an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.Bolt Biotherapeutics requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Bolt will consider requests for Reasonable Accommodations.
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Perform conjugation (lysine, cysteine, site specific, etc.) of antibodies to diverse linker-payloads on mg to gram scale, following established protocols and procedures.Conduct purification of the antibody drug conjugates utilizing various chromatographic techniques (affinity chromatography, size exclusion chromatography, ion exchange chromatography, membrane filtration (TFF), etc.)Perform analytical characterization of the antibodies and bioconjugates using analytical techniques including UV-Vis, HIC, SEC, RP-HPLC, and LC-MS.Maintain accurate records of experiments, results, and analytical data. Adhere to safety guidelines and protocols in the laboratory environment.Qualifications:
Bachelor's or Master's degree in biochemistry or related discipline with 2+ years of industrial or academic experience in bioconjugation.Hands-on experience with conjugation, purification, and analytical characterization of antibody drug conjugates.Ability to work both independently & collaboratively and willingness to learn new bioconjugation chemistries/techniques.Strong communication skills, collaborative, self-motivated, goal-oriented, and strong teamwork in a fast-paced setting.$60,000 - $85,000 a year
We are an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.Bolt Biotherapeutics requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Bolt will consider requests for Reasonable Accommodations.
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