Senior Scientist - ADC Biology

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.At Pfizer we deliver breakthroughs that change patients' lives. The ADC Biology team plays a vital role in this mission through discovering and advancing novel ADCs while utilizing comprehensive biological evaluation of tumor associated antigens and linker payloads. To discover the next generation of therapeutics, we are seeking a highly collaborative scientific leader with expertise in cancer cell biology.POSITION SUMMARYThe successful candidate will be responsible for designing and executing preclinical discovery research activities in collaboration with cross functional project teams for drug development candidates. This individual will directly contribute to Pfizer Oncology pipeline and will be expected to drive collaborative efforts with cancer biologists, immunologists, chemists, and protein engineers to innovate and develop first-in-class oncology therapies. The successful candidate should have a record of being a strong scientist, team player, strategic thinker, and an effective communicator.KEY RESPONSIBILITIESDesign, conduct, analyze, interpret and document experiments utilizing a diverse array of techniques aimed at identifying and characterizing novel tumor associated antigens and evaluating novel ADC payloads.Execute molecular and cell-based methodologies including cytotoxicity assays, reporter assays, ELISA, western blotting, WES, in vitro PD assays, and flow cytometry.Leverage cell surface target biology to guide therapeutic design and identify the appropriate preclinical models for therapeutic design validation.Design and execute comprehensive experimental plans that inform and enable project progression. Define clear go/no go criteria for projects in alignment with overall research and corporate strategy.Serve as a subject matter expert in cancer biology; stay abreast of relevant literature and act as an expert resource within research.Work independently and demonstrate the ability to collaboratively contribute to projects outside their own expertise.Present research results and methodologies at meetings with immediate supervisor and/or project leader, project team meetings and other research forums.Contribute to building a culture that embraces scientific excellence, urgency, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development.QUALIFICATIONSPh.D. degree or equivalent experience in Cancer Biology, Cell biology, Biochemistry, Engineering or a related field. Post-doctoral training in Cancer Biology or a related field is strongly preferred. Ability to adapt and adjust to a rapidly evolving environment. Ability to identify and plan critical path experiments in alignment with team objectives. Uses critical thinking to solve complex problems, address challenges and overcome obstacles. Understanding of appropriate statistical design and analysis for pre-clinical experiments. Highly effective interpersonal skills, ability to identify and absorb critical information and convey it to relevant stakeholders. Strong written and verbal communication skills with the ability to communicate effectively to a wide range of audiences.

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