Skills Alliance
Research Associate II, Protein Sciences and Structural Biology
Skills Alliance, Cambridge, Massachusetts, us, 02138
We are currently seeking a highly motivated and passionate research associate to support drug discovery projects. We will provide cutting-edge protein sciences and structural biology professional training to support the candidate in driving therapeutic discovery at the bench through the production, characterization and crystallization of therapeutic protein targets. The successful candidate will have a solid understanding of protein biochemistry and molecular biology. Experience in structural biology is advantageous.
This is a 6-month contract position with the possibility of turning into a full-time role depending on business needs.
CHARACTERISTIC DUTIESDeveloping and executing strategies to clone and express recombinant proteins in a variety of cell culture systemsPurifying tagged or native proteins using standard purification (FPLC systems and column chromatography) and analytical techniques (SDS-PAGE, Western blot, light scattering, and protein LC/MS)With training, produce high quality protein crystal structures and co-crystal structures, carrying out the process from crystallization screening through to structure refinementSupporting the crystallographic pipeline through protein design, expression, purification, and biophysical characterizationDemonstrating the ability to interpret experimental outcomes and proposing follow-up studiesDocumenting work, managing, analyzing and effectively presenting results to multi-disciplinary project teamsWorking in partnership with team members and collaborators to best achieve results
QUALIFICATIONSB.S. or M.S. in Molecular Biology, Biochemistry, Biophysics or a related life science field with 0-2 years research experience in an academic or industrial settingExperience with molecular cloning and vector construction, bacterial expression, and protein purification through conventional and affinity-based chromatographic approaches is desiredExperience in the functional characterization of recombinant proteins and biophysical characterization of protein-protein and/or protein-small molecule interactions is desiredKnowledge in protein crystallography, cryo-EM, or NMR is advantageousA proven record of successful communication and interaction with project team members, external customers or vendors is advantageous
The successful candidate will be a results-focused, team-oriented scientist able to excel in a fast-track environment across multiple projects. They must be accountable, self-motivated, detail-oriented and exhibit problem solving skills. In addition, the successful candidate will be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with team members.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.
EEO is The Law - click here for more information
Equal Opportunity Employer Minorities/Women/Protected Veterans/DisabledAll qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.EEO is The Law - click here for more informationEqual Opportunity Employer Minorities/Women/Protected Veterans/Disabled
This is a 6-month contract position with the possibility of turning into a full-time role depending on business needs.
CHARACTERISTIC DUTIESDeveloping and executing strategies to clone and express recombinant proteins in a variety of cell culture systemsPurifying tagged or native proteins using standard purification (FPLC systems and column chromatography) and analytical techniques (SDS-PAGE, Western blot, light scattering, and protein LC/MS)With training, produce high quality protein crystal structures and co-crystal structures, carrying out the process from crystallization screening through to structure refinementSupporting the crystallographic pipeline through protein design, expression, purification, and biophysical characterizationDemonstrating the ability to interpret experimental outcomes and proposing follow-up studiesDocumenting work, managing, analyzing and effectively presenting results to multi-disciplinary project teamsWorking in partnership with team members and collaborators to best achieve results
QUALIFICATIONSB.S. or M.S. in Molecular Biology, Biochemistry, Biophysics or a related life science field with 0-2 years research experience in an academic or industrial settingExperience with molecular cloning and vector construction, bacterial expression, and protein purification through conventional and affinity-based chromatographic approaches is desiredExperience in the functional characterization of recombinant proteins and biophysical characterization of protein-protein and/or protein-small molecule interactions is desiredKnowledge in protein crystallography, cryo-EM, or NMR is advantageousA proven record of successful communication and interaction with project team members, external customers or vendors is advantageous
The successful candidate will be a results-focused, team-oriented scientist able to excel in a fast-track environment across multiple projects. They must be accountable, self-motivated, detail-oriented and exhibit problem solving skills. In addition, the successful candidate will be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with team members.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.
EEO is The Law - click here for more information
Equal Opportunity Employer Minorities/Women/Protected Veterans/DisabledAll qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.EEO is The Law - click here for more informationEqual Opportunity Employer Minorities/Women/Protected Veterans/Disabled