Scientist - Biologics Research

Company Description Insmed is a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion. Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves. If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career. Recognitions Consistently Ranked Science 's Top Employer Insmed is dedicated to creating a collaborative environment where our team can thrive. Every day, our employees turn their passion for science and research into innovative solutions for patients. That's why we've been named the No. 1 company to work for in the biopharma industry in Science 's Top Employers survey for four years in a row. A Certified Great Place to Work® We believe our company is truly special, and our employees agree. In July 2024, we became Great Place to Work-certified in the U.S. for the fourth year in a row. We are also honored to have been listed on the Best Workplaces in Biopharma™, Best Workplaces in New York™, PEOPLE® Companies That Care, Best Workplaces for Women™, Best Workplaces for Millennials™, and Best Medium Workplaces™ lists. Overview We are seeking a highly motivated Scientist to support discovery and development campaigns focused on next-generation biotherapies for serious unmet medical needs. The candidate will work within a multidisciplinary team of scientists focused on the design, engineering, formulation development, and preclinical characterization of ground-breaking biotherapeutics. Specifically, the candidate will help lead engineering and optimization campaigns for a diverse array of biomolecular scaffolds including enzymes, catalysts, binding and targeting moieties, signaling molecules, and drug delivery platforms of biological origin. Responsibilities Help drive biomolecular engineering, immunology, and pharmacology efforts within Insmed research projects, including strategy and methods development Construct recombinant systems encoding protein variants and combinatorial protein libraries Conceptualize, construct, validate, and implement high throughput screening platforms to enable candidate selection from large panels and/or combinatorial libraries of engineered protein variants Devise, optimize, and employ tailored protein expression and purification strategies for drug discovery programs Develop, validate, and deploy functional, immunological, and pharmacological, assays to characterize protein performance in vitro (both exogenous and cell-based assays) and in vivo Maintain accurate, detailed, and timely records of methods development, experimental data, and data analysis in an electronic notebook system Perform data review to ensure accuracy, completeness, and validity Participate in cross-disciplinary mentoring and training within the research team Present scientific results to the larger Insmed research group and external scientific community, as needed Qualifications Requires a minimum of a PhD in molecular and cellular biology, bioengineering, biochemistry, immunology, microbiology, or related field Experience with yeast surface display (YSD) libraries is strongly preferred Deep technical understanding of and hands-on experience with molecular and cellular biology, mammalian tissue culture, recombinant DNA technology, protein mutagenesis, and protein biochemistry Experience with recombinant protein expression and purification as well as routine protein characterization methods including but not limited to spectroscopy, SDS-PAGE, western blot, and ELISA Experience with enzyme analysis and characterization and/or protein-protein binding analysis and characterization Experience with high throughput functional screen development for protein libraries, AAV viral vectors, gene editing, and in vivo (rodent) are also preferred but not required Must have excellent communication (verbal and written) and problem-solving skills Highly organized with a strong attention to detail, clarity, accuracy, and conciseness Proven track record in methods development, including experimental design, execution, and evaluation Salary Range $89,000 - $119,267 a year Compensation & Benefits We're committed to investing in every team member's total well-being, now and in the future. We offer a competitive total-rewards package to all employees around the world, including: Flexible approach to where and how we work, regionally based Competitive compensation package including bonus Stock options and RSU awards Employee Stock Purchase Plan (ESPP) Flexible Vacation Policy Generous paid holiday schedule and winter break ADDITIONAL U.S. BENEFITS: 401(k) plan with company match Medical, dental, and vision plans Company-provided Life and Accidental Death & Dismemberment (AD&D) insurance Company-provided short and long-term disability benefits Unique offerings of pet, legal, and supplemental life insurance Flexible spending accounts for medical and dependent care Accident and Hospital Indemnity insurance Employee Assistance Program (EAP) Mental Health on-line digital resource Well-being reimbursement Paid leave benefits for new parents Paid time off to volunteer On-site, no-cost fitness center at our U.S. headquarters Additional Information Insmed Incorporated is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law. Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement. Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at TotalRewardsinsmed.com and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address. Applications are accepted for 5 calendar days from the date posted or until the position is filled.