Postdoctoral Researcher, Chemical Biology

Description Note: this is an onsite position starting in January 2025. The application window is open until November 4, 2024. Company Overview: Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered "undruggable". Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space. We are uniquely structured with opportunities for all scientists to contribute to both established programs as well as ongoing early target selection, screens and validation. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression. Vividion was ranked #2 mid-size company on The San Diego Union-Tribune's 2022 and 2023 Top Workplaces list. Job Summary: The successful candidate will have extensive hands-on experience and expertise in the evaluation of the impact of protein-protein interactions on protein function and stability both in vitro and in a cellular context via cell and/or biochemical assay development. This position will be responsible for leading/supporting efforts towards the discovery of protein-protein interactions of therapeutically-relevant drug discovery targets. Requirements Education and Experience requirements: PhD with experience in biochemistry, chemical biology, cell biology or related disciplines Required technical skills include a strong molecular biology skill set (e.g., DNA cloning, site-directed mutagenesis, CRISPR, transient transfection, viral transduction), Protein expression analysis (western blot/ ELISA/ProteinSimple), mammalian cell culture, microscopy, and functional/phenotypic assays (Cell Viability 2D and 3D, Soft agar, Apoptosis) Working knowledge of mass spectrometry-based proteomics analyses is a plus Required Key Attributes: Candidates must have strong communication skills as evidenced in public presentations and/or peer reviewed literature. Candidates must have effective troubleshooting and problem-solving skills. Candidates must be an effective team player, strong individual contributor, flexible, and able to handle multiple tasks. Pay & Benefits: The expected compensation for this position is between $75,000 to $85,000 per year commensurate with experience. EEO & Employment Eligibility: Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Privacy Policy: The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit

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