Tbwa Chiat/Day Inc
Principal Scientist of Gene Editing
Tbwa Chiat/Day Inc, Piscataway, New Jersey, United States,
Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.
Legend Biotech is seeking a
Principal Scientist of Genome Editing
as part of the
Research and Early Development team based in
Piscataway, NJ. Role Overview Legend Biotech is an international clinical stage biopharmaceutical company focused on the discovery and development of novel cell therapies for oncology, immunology and infectious disease indications. We are seeking a Senior Scientist with a track record of research excellence of synthetic biology to join our cancer immunotherapy team. Expertise in genome editing and off-target analysis is required. The ideal candidate will be a highly motivated individual who enjoys having broad responsibilities. You thrive in a collaborative work environment and are skilled at advancing multiple projects concurrently. Knowledge of state-of-art immunotherapy and its applications. As part of the Legend Biotech R&D team, you will be responsible for timely execution of projects in our discovery pipeline. Key Responsibilities Conduct gRNA screening using Base editor in primary immune effector cells to determine the KO efficiency and select best gRNA for product development Lead, design and execute functional assays to validate off-target issue in primary immune effector cells after gene editing Develop and execute in-house NGS workflows, including library preparation and troubleshooting Conduct in vitro functional evaluation of gene edited immune effector cells Maintain an accurate and updated laboratory notebook Maintain compliance with GLP and EHS protocols Prepare and present reports, publications, oral presentations and patent application documents Requirements
Education:
Ph. D. in genetics, molecular biology, immunology, oncology or related fields
Experience:
4+ years of experience in the field of genome editing 2+ years hands-on experience using next generation CRISPR systems (e.g. Prime or Base editors) Strong expertise in immunotherapy and cell therapy preferred Strong experience with NGS library preparation and troubleshooting Hands on experience with off-target assay development, experience with base editor is preferred Extensive experience of NGS sequencing and data analysis Experience of immune cell isolation, activation, gene delivery and expansion
Key Capabilities, Knowledge, and Skills:
Strong experiences with off-target assay development and analysis Deep expertise in analytic RNA or DNA assays to measure and analyze gene editing results Experience in utilizing bioinformatics tools and software for the analysis of gene editing readouts Experience in gene delivery of mammalian cell and tissue culturing is required Strong problem-solving skills Excellent verbal and written communication skills Ability to operate under minimal supervision and in a team environment
#Li-JK1 #Li-Onsite Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law. Legend Biotech maintains a drug-free workplace. Apply for this job
* indicates a required field First Name * Last Name * Email * Phone * Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf Are you authorized to work lawfully in the United States? * Select... Will you now or in the future require sponsorship for employment visa status (e.g., H-1B visa status)? * Select... Were you referred by an internal employee of Legend Biotech? * Select... If referred by an internal employee of Legend Biotech, please list their name. Are you a relative of any employee at Legend Biotech? * Select... If you are a relative to an employee at Legend Biotech, please list their name. What is your desired salary? * Permanent Address * Are you open to relocation? * Select... How did you hear about us? * Select... Current/Most Recent Employer * Current/Most Recent Title * LinkedIn Profile Preferred First Name Voluntary Self-Identification
For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file. As set forth in Legend Biotech US’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law. If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability. A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service. An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense. An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985. Select... Voluntary Self-Identification of Disability
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We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years. Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp . How do you know if you have a disability?
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Principal Scientist of Genome Editing
as part of the
Research and Early Development team based in
Piscataway, NJ. Role Overview Legend Biotech is an international clinical stage biopharmaceutical company focused on the discovery and development of novel cell therapies for oncology, immunology and infectious disease indications. We are seeking a Senior Scientist with a track record of research excellence of synthetic biology to join our cancer immunotherapy team. Expertise in genome editing and off-target analysis is required. The ideal candidate will be a highly motivated individual who enjoys having broad responsibilities. You thrive in a collaborative work environment and are skilled at advancing multiple projects concurrently. Knowledge of state-of-art immunotherapy and its applications. As part of the Legend Biotech R&D team, you will be responsible for timely execution of projects in our discovery pipeline. Key Responsibilities Conduct gRNA screening using Base editor in primary immune effector cells to determine the KO efficiency and select best gRNA for product development Lead, design and execute functional assays to validate off-target issue in primary immune effector cells after gene editing Develop and execute in-house NGS workflows, including library preparation and troubleshooting Conduct in vitro functional evaluation of gene edited immune effector cells Maintain an accurate and updated laboratory notebook Maintain compliance with GLP and EHS protocols Prepare and present reports, publications, oral presentations and patent application documents Requirements
Education:
Ph. D. in genetics, molecular biology, immunology, oncology or related fields
Experience:
4+ years of experience in the field of genome editing 2+ years hands-on experience using next generation CRISPR systems (e.g. Prime or Base editors) Strong expertise in immunotherapy and cell therapy preferred Strong experience with NGS library preparation and troubleshooting Hands on experience with off-target assay development, experience with base editor is preferred Extensive experience of NGS sequencing and data analysis Experience of immune cell isolation, activation, gene delivery and expansion
Key Capabilities, Knowledge, and Skills:
Strong experiences with off-target assay development and analysis Deep expertise in analytic RNA or DNA assays to measure and analyze gene editing results Experience in utilizing bioinformatics tools and software for the analysis of gene editing readouts Experience in gene delivery of mammalian cell and tissue culturing is required Strong problem-solving skills Excellent verbal and written communication skills Ability to operate under minimal supervision and in a team environment
#Li-JK1 #Li-Onsite Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law. Legend Biotech maintains a drug-free workplace. Apply for this job
* indicates a required field First Name * Last Name * Email * Phone * Resume/CV * Enter manually Accepted file types: pdf, doc, docx, txt, rtf Enter manually Accepted file types: pdf, doc, docx, txt, rtf Are you authorized to work lawfully in the United States? * Select... Will you now or in the future require sponsorship for employment visa status (e.g., H-1B visa status)? * Select... Were you referred by an internal employee of Legend Biotech? * Select... If referred by an internal employee of Legend Biotech, please list their name. Are you a relative of any employee at Legend Biotech? * Select... If you are a relative to an employee at Legend Biotech, please list their name. What is your desired salary? * Permanent Address * Are you open to relocation? * Select... How did you hear about us? * Select... Current/Most Recent Employer * Current/Most Recent Title * LinkedIn Profile Preferred First Name Voluntary Self-Identification
For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file. As set forth in Legend Biotech US’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law. If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability. A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service. An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense. An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985. Select... Voluntary Self-Identification of Disability
Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 04/30/2026 Voluntary Self-Identification of Disability Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 04/30/2026 Why are you being asked to complete this form?
We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years. Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp . How do you know if you have a disability?
A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability.
Disabilities include, but are not limited to: Alcohol or other substance use disorder (not currently using drugs illegally) Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS Blind or low vision Cancer (past or present) Cardiovascular or heart disease Celiac disease Cerebral palsy Deaf or serious difficulty hearing Diabetes Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders Epilepsy or other seizure disorder Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome Intellectual or developmental disability Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD Missing limbs or partially missing limbs Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS) Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities Partial or complete paralysis (any cause) Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema Short stature (dwarfism) Traumatic brain injury
Disability Status Select... PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.
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