Associate Director/Director, Computational Biologist San Francisco, California,

BridgeBio

is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 20+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.Our focus on scientific excellence and rapid execution aim to translate today’s discoveries into tomorrow’s medicines. We have U.S. offices in San Francisco, Palo Alto, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zurich, Switzerland, and are expanding across Europe.The Computational Genetics team is seeking a full-time Computational Biologist who will guide strategic initiatives and directly contribute to identifying and extracting biological insights from high dimensional multi-omics data. The team provides data driven insights to make critical decisions for pursuing new opportunities and advancing internal development projects across early discovery and clinical stage programs. The successful candidate will be working alongside human geneticists, data scientists as well as experimental biologists for the ultimate goal of developing drugs for genetic diseases with high unmet need. The role involves leveraging methods from multiple disciplines including computational genetics, statistical inference, and machine learning.The Computational Genetics team at BridgeBio has three main goals:Initiate and support new drug program opportunities through data-driven approaches not obtainable through reading the literatureSupport clinical-stage programs through analyzing complex multi-omics datasets as well as propose required data and experimentsDevelop and deploy internal data & analysis infrastructure to scale operations across the companyThis is a great opportunity for getting broad exposure to the drug development process and working in a growth oriented environment.Responsibilities

Evaluate and contextualize the molecular evidence supporting a genetic disease therapeutic hypothesis with relevant human-derived multi-omics dataGuide strategic cross-functional initiatives for exploratory biomarker analysis for target engagement, patient stratification, surrogate endpoints, etc.Design and develop analysis frameworks to utilize data from diverse multiomics sources (ex. Genomics, trancriptomics, epigenomics, proteomics, chemoproteomics, etc.)Interact with both technical and non-technical collaborators, including biologists, physicians, geneticists, and business development & asset acquisition specialists, to evaluate new opportunities and derive analysis-based project decisionsStay current with state-of-the-art methods and most recent data releases, which will require reading academic papers, reproducing algorithms and methods with or without open-source software and ingesting relevant datasets for analyses across various sourcesNo matter your role at BridgeBio, successful team members are:Patient Champions, who put patients first and uphold strict ethical standardsEntrepreneurial Operators, who drive toward practical solutions and have an ownership mindsetTruth Seekers, who are detailed, rational, and humble problem solversIndividuals Who Inspire Excellence in themselves and those around themHigh-quality executors, who execute against goals and milestones with quality, precision, and speedEducation, Experience & Skills Requirements

PhD in Bioinformatics, Computational Biology, Functional Genomics or related discipline with 5+ years of industry experience applying multi-omics data analyses in the human contextHas direct experience with databases that house multi-omics datasets such as UK Biobank, Human Cell Atlas, Human Protein Atlas, GEO, Expression Atlas, DepMap, etc.Understands the limitations of high-throughput data with direct experience in quality control across multiple types of omics data, as well as how to assess quality of summarized resultsExpert level of proficiency in quantitative analyses, including mathematics, statistics and computationAble to demonstrate great written and verbal communication skills in conveying analysis results to both experts and non-experts in the fieldExtensive experience with Python focusing on data analysis and familiarity with git version control; hands on experience in developing data processing pipelines and or developing stand-alone libraries is a plusUnderstands AWS infrastructure, including EC2, S3 and knowledge of relational databases (SQL, Postgres, etc…); experience in extracting information from such databasesProven track record of peer-reviewed publications in computational biologyWhat We Offer

Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our effortsA culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speakAn unyielding commitment to always putting patients first. Learn more about how we do this hereA de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the scienceA place where you own the vision – both for your program and your own career pathA collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our gameAccess to learning and development resources to help you get in the best professional shape of your lifeRobust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)Flexible PTORapid career advancement for strong performersPotential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over timeCommitment to Diversity, Equity & InclusionAt BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states.#J-18808-Ljbffr