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Arrowhead Pharmaceuticals, Inc

Scientist, Discovery Med Chemistry

Arrowhead Pharmaceuticals, Inc, San Diego, California, United States, 92189


Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.The Position

Arrowhead Pharma is seeking one skilled and motivated synthetic organic chemist.Responsibilities

Design and timely synthesize small molecules and peptides to support discovery projectsReview research papers and intellectual property literature in support of SAR of oligonucleotide drug design and or deliveryTrack progress against project timelines, generate regular status updates and communicate progress and issues to team leadersRequirements:

Ph.D. in organic chemistry with 0 to 2 years of pharmaceutical industry experience, or M.S. degree with at least 5 years of experience in organic synthesis in the pharmaceutical industryStrong laboratory experience with analytical instruments, such as NMR, LC-MS, RP-HPLC, etc., is requiredHighly innovative and creative in problem solvingSelf-motivated with strong working ethicsA good team playerSalary: $100,000 — $130,000 USDArrowhead provides competitive salaries and an excellent benefit package.All applicants must have authorization to work in the US for a company.

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