Associate Scientist, Biology (In Vivo)

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.The Position

Arrowhead is seeking a highly motivated biologist to join our growing CNS

in vivo

team within the Research Department at our San Diego site. The successful candidate will be joining a team dedicated to discovering, developing and translating novel drug targets.Responsibilities

Perform in vivo studies and ex vivo analysis to facilitate drug discovery and development in various diseasesEstablish new preclinical animal disease modelsPerform animal behavior studies as neededCoordinate processes across departments and with outside vendors to enable efficient study execution and data generationRead and apply relevant scientific literature to projects to troubleshoot and solve problemsPresent research findings to project teams and prepare technical reportsMaintain a high level of productivity in the lab and perform critical experimentsRequirements

BS and/or MS in biology related fieldExtensive experience with small animal handlingExperience with sample collection / tissue collectionExcellent record keeping and experience in data analysis, graphing and presentationAbility to work independently and to handle multiple projects and deadlinesDemonstrated innovation, creativity and resilience in problem solvingExcellent oral and written communication skillsSelf-motivated team player with the ability to thrive in a fast paced, multi-disciplinary, matrixed environmentPreferred

Experience with CNS surgeries and/or drug administration locally in CNSExperiences with animal dose administration and surgical proceduresPreclinical disease model development in the context of drug discoveryCalifornia pay range

$65,000—$80,000 USDArrowhead provides competitive salaries and an excellent benefit package.All applicants must have authorization to work in the US for a company.California Applicant Privacy Policy

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