Dana-Farber Cancer Institute (DFCI)
Postdoctoral Research Fellow - Wolpin-Nowak Lab
Dana-Farber Cancer Institute (DFCI), Boston, Massachusetts, us, 02298
Postdoctoral Research Fellow - Wolpin-Nowak LabDana-Farber Cancer InstituteBoston, MAFull Time
The Dana-Farber Cancer Institute seeks a Research Fellow to focus on next-generation, translational pathology studies who will work within the Wolpin-Nowak laboratory as part of the Hale Family Center for Pancreatic Cancer Research ( http://halecenter.dfci.harvard.edu ) and the Lustgarten Foundation Pancreatic Cancer Research Laboratory at the Dana-Farber Cancer Institute ( https://www.lustgarten.org/research/our-lab/ ).
The Wolpin-Nowak laboratory studies the epidemiology and biology of pancreatic ductal adenocarcinoma (PDAC). The pathology portion of the laboratory is focused on multimodal characterization of human PDAC specimens from large landscape cohorts as well as specimens collected for clinical trial correlative studies. We employ and develop genomic, transcriptomic, and protein-based techniques to study PDAC and its microenvironment with a focus on digital imaging, spatial technologies, and automated analysis pipelines driven by machine learning.
Responsibilities
Design and conduct studies using multiplex immunofluorescence, spatial transcriptional profiling, and other high-dimension tissue analysis approaches to evaluate pancreatic cancer pathology using human tissue specimens.
Assemble analysis pipelines using machine learning to process tissue data reproducibly and at scale.
Conduct analyses using programming languages such as R and Python.
Collaborate with other laboratory members with expertise in epidemiology, bioinformatics, pathology, molecular biology, and functional genomics.
Participate in group meetings and work collaboratively on larger projects with other group members.
Lead projects that result in first author manuscripts.
Write grants and progress reports related to research funding.
Qualifications
Candidates should hold a doctoral degree in genetics/genomics, cancer biology, pathology or related fields. Multidisciplinary training and experience in multiple of these fields is desirable. MD or MD-equivalent and PhD-holding candidates will both be considered; MD/PhD-holding candidates with pathology training are highly encouraged to apply.
Knowledge, Skills, & Abilities Required:
Strong background in human pathology.
Experience with traditional pathology laboratory techniques, including slide sectioning, H&E staining, immunohistochemistry and special stains a plus.
Experience with translational pathology technique, including multiplexed immunofluorescence, spatial transcriptomics, and RNA in situ hybridization a plus.
Experience with digital image analysis platforms (Halo, VisioPharm, QuPath, InForm, etc.) a plus.
Experience with R, Python, and commonly used libraries/packages a plus.
Enthusiasm for novel assay and technology development.
Ability to independently analyze information and troubleshoot when required.
Excellent written and verbal communication skills.
Attention to detail and thoroughness in completing work tasks.
Ability to work within a team environment.
Adaptability to a fast-paced, dynamic environment.
For more information and to apply, please visit:
https://careers.dana-farber.org/postdoc-research-fellow-wolpin-nowak-lab
#J-18808-Ljbffr
The Dana-Farber Cancer Institute seeks a Research Fellow to focus on next-generation, translational pathology studies who will work within the Wolpin-Nowak laboratory as part of the Hale Family Center for Pancreatic Cancer Research ( http://halecenter.dfci.harvard.edu ) and the Lustgarten Foundation Pancreatic Cancer Research Laboratory at the Dana-Farber Cancer Institute ( https://www.lustgarten.org/research/our-lab/ ).
The Wolpin-Nowak laboratory studies the epidemiology and biology of pancreatic ductal adenocarcinoma (PDAC). The pathology portion of the laboratory is focused on multimodal characterization of human PDAC specimens from large landscape cohorts as well as specimens collected for clinical trial correlative studies. We employ and develop genomic, transcriptomic, and protein-based techniques to study PDAC and its microenvironment with a focus on digital imaging, spatial technologies, and automated analysis pipelines driven by machine learning.
Responsibilities
Design and conduct studies using multiplex immunofluorescence, spatial transcriptional profiling, and other high-dimension tissue analysis approaches to evaluate pancreatic cancer pathology using human tissue specimens.
Assemble analysis pipelines using machine learning to process tissue data reproducibly and at scale.
Conduct analyses using programming languages such as R and Python.
Collaborate with other laboratory members with expertise in epidemiology, bioinformatics, pathology, molecular biology, and functional genomics.
Participate in group meetings and work collaboratively on larger projects with other group members.
Lead projects that result in first author manuscripts.
Write grants and progress reports related to research funding.
Qualifications
Candidates should hold a doctoral degree in genetics/genomics, cancer biology, pathology or related fields. Multidisciplinary training and experience in multiple of these fields is desirable. MD or MD-equivalent and PhD-holding candidates will both be considered; MD/PhD-holding candidates with pathology training are highly encouraged to apply.
Knowledge, Skills, & Abilities Required:
Strong background in human pathology.
Experience with traditional pathology laboratory techniques, including slide sectioning, H&E staining, immunohistochemistry and special stains a plus.
Experience with translational pathology technique, including multiplexed immunofluorescence, spatial transcriptomics, and RNA in situ hybridization a plus.
Experience with digital image analysis platforms (Halo, VisioPharm, QuPath, InForm, etc.) a plus.
Experience with R, Python, and commonly used libraries/packages a plus.
Enthusiasm for novel assay and technology development.
Ability to independently analyze information and troubleshoot when required.
Excellent written and verbal communication skills.
Attention to detail and thoroughness in completing work tasks.
Ability to work within a team environment.
Adaptability to a fast-paced, dynamic environment.
For more information and to apply, please visit:
https://careers.dana-farber.org/postdoc-research-fellow-wolpin-nowak-lab
#J-18808-Ljbffr