Dana-Farber Cancer Institute (DFCI)
Postdoctoral Research Fellow - Qi Lab
Dana-Farber Cancer Institute (DFCI), Boston, Massachusetts, us, 02298
Postdoctoral Research Fellow - Qi Lab
Dana-Farber Cancer Institute
Boston, MA
Full Time
The Qi laboratory at the Dana-Farber Cancer Institute is looking for an exceptional Postdoctoral Fellow in cancer biology (qilab.dana-farber.org). The Qi lab studies gene regulatory pathways using the emerging discipline of chemical biology. The successful candidate will work with an interdisciplinary team of scientists including medicinal chemists, biochemists, computational biologists, and cancer biologists to develop novel inhibitors of chromatin modifying enzymes, such as methyltransferases, demethylases and bromodomains. The candidate will perform research that will help make fundamental insights to cancer biology using novel small molecule inhibitors to gain mechanistic understanding in cancer therapy. We expect that novel therapeutics for human clinical investigation will emerge directly from these efforts through academic/industry collaborations.
The postdoctoral fellow will be affiliated with the Department of Cancer Biology at Dana-Farber Cancer Institute, the Department of Medicine at Harvard Medical School and the Broad Institute.
Responsibilities
Developing and executing biological assays for inhibitor discovery and characterization while investigating novel biological mechanisms of action.
Performing cell and molecular biology research including but not limited to tissue culture, genetic manipulation through shRNA/CRISPR, routine protein/RNA/DNA analyses including ChIP-seq and RNA-seq.
Performing laboratory experiments and conducting data analysis.
Designing experiments and executing protocols.
Maintaining accurate records, writing reports, and preparing/giving presentations.
Performing preclinical translational studies in mouse models of cancer if interested.
Qualifications
PhD, MD/PhD, MD or doctoral equivalent in biological sciences or equivalent.
A strong background in biochemistry, cancer biology, molecular biology and/or cell biology.
Experience with mouse models of cancer (xenografts, PDXs, GEMMs) is a plus.
Excellent oral and written communication skills.
The ability to perform both self-directed and guided research is required.
Must demonstrate outstanding ability to work effectively as part of an interdisciplinary team of scientists.
For more information and to apply, please visit:
https://careers.dana-farber.org/postdoc-research-fellow-qi-lab
About Dana-Farber Cancer Institute:
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.
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The Qi laboratory at the Dana-Farber Cancer Institute is looking for an exceptional Postdoctoral Fellow in cancer biology (qilab.dana-farber.org). The Qi lab studies gene regulatory pathways using the emerging discipline of chemical biology. The successful candidate will work with an interdisciplinary team of scientists including medicinal chemists, biochemists, computational biologists, and cancer biologists to develop novel inhibitors of chromatin modifying enzymes, such as methyltransferases, demethylases and bromodomains. The candidate will perform research that will help make fundamental insights to cancer biology using novel small molecule inhibitors to gain mechanistic understanding in cancer therapy. We expect that novel therapeutics for human clinical investigation will emerge directly from these efforts through academic/industry collaborations.
The postdoctoral fellow will be affiliated with the Department of Cancer Biology at Dana-Farber Cancer Institute, the Department of Medicine at Harvard Medical School and the Broad Institute.
Responsibilities
Developing and executing biological assays for inhibitor discovery and characterization while investigating novel biological mechanisms of action.
Performing cell and molecular biology research including but not limited to tissue culture, genetic manipulation through shRNA/CRISPR, routine protein/RNA/DNA analyses including ChIP-seq and RNA-seq.
Performing laboratory experiments and conducting data analysis.
Designing experiments and executing protocols.
Maintaining accurate records, writing reports, and preparing/giving presentations.
Performing preclinical translational studies in mouse models of cancer if interested.
Qualifications
PhD, MD/PhD, MD or doctoral equivalent in biological sciences or equivalent.
A strong background in biochemistry, cancer biology, molecular biology and/or cell biology.
Experience with mouse models of cancer (xenografts, PDXs, GEMMs) is a plus.
Excellent oral and written communication skills.
The ability to perform both self-directed and guided research is required.
Must demonstrate outstanding ability to work effectively as part of an interdisciplinary team of scientists.
For more information and to apply, please visit:
https://careers.dana-farber.org/postdoc-research-fellow-qi-lab
About Dana-Farber Cancer Institute:
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.
#J-18808-Ljbffr