University of California - San Francisco
Specialist in Molecular Biology of Neurons
University of California - San Francisco, San Francisco, California, United States, 94199
Application WindowOpen date:
April 19, 2024Next review date:
Saturday, May 4, 2024 at 11:59pm (Pacific Time)Apply by this date to ensure full consideration by the committee.Final date:
Sunday, Oct 19, 2025 at 11:59pm (Pacific Time)Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.Position Description
Specialist in Molecular Biology of NeuronsThe Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking a motivated and enthusiastic individual to join our neuroscience research institute aimed at defining mechanisms underlying motor neuron disease (Lou Gehrig's disease, ALS) and dementia. The IND is directed by Dr. Stanley Prusiner and is located at UCSF's Mission Bay campus.The Mordes Lab within the IND focuses on understanding how disruptions in protein homeostasis and RNA metabolism result in the formation of protein inclusions within neurons and neurodegeneration, particularly ALS, Parkinson's disease, and forms of dementia. The research involves utilizing patient-derived and isogenic CRISPR-edited pluripotent stem cell lines and detailed neuropathology examination of patient brains.The specialist will engage in ongoing studies of human stem cell-derived neurons to model neurodegenerative diseases and related molecular biology assays.
The successful applicant will be an experienced cell and molecular biology researcher with expertise in biomedical research and in vitro cell culture methods.
The specialist will effectively communicate with all lab members and work as part of a team dedicated to understanding neurodegenerative diseases and advancing pre-clinical models of disease.A two-year commitment is preferred; and the candidate must be able to make a one-year commitment.The major responsibilities will include the maintenance and manipulation of stem cell lines, differentiation of stem cells to neurons, and imaging/monitoring of cells and neurons via microscopy.The specialist will be responsible for a range of molecular biology techniques, including quantitative analysis of gene expression, purification of RNA and DNA, plasmid preparation and cloning, immunoblotting, preparation of nucleic acid libraries, and immunostaining. Additional studies will involve the extraction and quality control of nucleic acid and proteins from brain tissue samples.The incumbent will be required to complete safety training and perform administrative and operational duties to maintain lab compliance.The incumbent will also be responsible for establishing additional molecular biology techniques for the lab, such as quantitative PCR and high throughput cellular assays.The incumbent will maintain detailed lab records and perform analysis of results and statistical assays using available software.The specialist will support the intellectual design of a research project, attend and present at regular lab meetings, and contribute to the broader scientific and medical community through opportunities to attend conferences and publish original papers.Personal Qualifications
Required:Possess a high sense of commitment for advancing biomedical research and career development.Excellent record-keeping and organizational abilities.Strong sense of responsibility with all lab duties.Education and Training Qualifications
Required:Junior Specialist: Baccalaureate degree in Biology, Molecular Biology, Neuroscience, Bioengineering or related fields or at least four years of research experience.Assistant Specialist: Master's degree in Biology, Molecular Biology, Neuroscience, Bioengineering or related fields or a baccalaureate degree with three or more years of research experience.Associate Specialist: Master's degree or five to ten years of relevant experience.Full Specialist: A terminal degree or ten or more years of relevant experience.Technical Qualifications
Required:Demonstrated experience in performing mammalian cell culture and experimental protocols.Working knowledge of basic lab techniques and molecular biology methods.Ability to perform basic mathematical calculations and statistical tests in spreadsheet formats.Preferred:Expertise in human pluripotent stem cell maintenance, differentiation to neurons, and biological assay development.Biochemistry and Molecular biology expertise including protein, RNA, and DNA purification and analysis.Candidates must meet the required qualifications at the time of appointment. Candidate's CV must state qualifications (or if pending) upon submission.Please apply online at https://aprecruit.ucsf.edu/JPF05048, with a CV, cover letter, and three references.See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$181,800.APPLICATION REQUIREMENTS
Document requirements:Curriculum Vitae - CV must clearly list current and/or pending qualifications.Cover LetterReference requirements: 3 required (contact information only)About UC San Francisco
As a University employee, you will be required to comply with all applicable University policies. UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer.Job Location
San Francisco, CA
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April 19, 2024Next review date:
Saturday, May 4, 2024 at 11:59pm (Pacific Time)Apply by this date to ensure full consideration by the committee.Final date:
Sunday, Oct 19, 2025 at 11:59pm (Pacific Time)Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.Position Description
Specialist in Molecular Biology of NeuronsThe Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking a motivated and enthusiastic individual to join our neuroscience research institute aimed at defining mechanisms underlying motor neuron disease (Lou Gehrig's disease, ALS) and dementia. The IND is directed by Dr. Stanley Prusiner and is located at UCSF's Mission Bay campus.The Mordes Lab within the IND focuses on understanding how disruptions in protein homeostasis and RNA metabolism result in the formation of protein inclusions within neurons and neurodegeneration, particularly ALS, Parkinson's disease, and forms of dementia. The research involves utilizing patient-derived and isogenic CRISPR-edited pluripotent stem cell lines and detailed neuropathology examination of patient brains.The specialist will engage in ongoing studies of human stem cell-derived neurons to model neurodegenerative diseases and related molecular biology assays.
The successful applicant will be an experienced cell and molecular biology researcher with expertise in biomedical research and in vitro cell culture methods.
The specialist will effectively communicate with all lab members and work as part of a team dedicated to understanding neurodegenerative diseases and advancing pre-clinical models of disease.A two-year commitment is preferred; and the candidate must be able to make a one-year commitment.The major responsibilities will include the maintenance and manipulation of stem cell lines, differentiation of stem cells to neurons, and imaging/monitoring of cells and neurons via microscopy.The specialist will be responsible for a range of molecular biology techniques, including quantitative analysis of gene expression, purification of RNA and DNA, plasmid preparation and cloning, immunoblotting, preparation of nucleic acid libraries, and immunostaining. Additional studies will involve the extraction and quality control of nucleic acid and proteins from brain tissue samples.The incumbent will be required to complete safety training and perform administrative and operational duties to maintain lab compliance.The incumbent will also be responsible for establishing additional molecular biology techniques for the lab, such as quantitative PCR and high throughput cellular assays.The incumbent will maintain detailed lab records and perform analysis of results and statistical assays using available software.The specialist will support the intellectual design of a research project, attend and present at regular lab meetings, and contribute to the broader scientific and medical community through opportunities to attend conferences and publish original papers.Personal Qualifications
Required:Possess a high sense of commitment for advancing biomedical research and career development.Excellent record-keeping and organizational abilities.Strong sense of responsibility with all lab duties.Education and Training Qualifications
Required:Junior Specialist: Baccalaureate degree in Biology, Molecular Biology, Neuroscience, Bioengineering or related fields or at least four years of research experience.Assistant Specialist: Master's degree in Biology, Molecular Biology, Neuroscience, Bioengineering or related fields or a baccalaureate degree with three or more years of research experience.Associate Specialist: Master's degree or five to ten years of relevant experience.Full Specialist: A terminal degree or ten or more years of relevant experience.Technical Qualifications
Required:Demonstrated experience in performing mammalian cell culture and experimental protocols.Working knowledge of basic lab techniques and molecular biology methods.Ability to perform basic mathematical calculations and statistical tests in spreadsheet formats.Preferred:Expertise in human pluripotent stem cell maintenance, differentiation to neurons, and biological assay development.Biochemistry and Molecular biology expertise including protein, RNA, and DNA purification and analysis.Candidates must meet the required qualifications at the time of appointment. Candidate's CV must state qualifications (or if pending) upon submission.Please apply online at https://aprecruit.ucsf.edu/JPF05048, with a CV, cover letter, and three references.See Table 24B for the salary range for this position. A reasonable estimate for this position is $51,300-$181,800.APPLICATION REQUIREMENTS
Document requirements:Curriculum Vitae - CV must clearly list current and/or pending qualifications.Cover LetterReference requirements: 3 required (contact information only)About UC San Francisco
As a University employee, you will be required to comply with all applicable University policies. UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer.Job Location
San Francisco, CA
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