Dana-Farber Cancer Institute (DFCI)
Postdoctoral Research Fellow – Fischer Lab
Dana-Farber Cancer Institute (DFCI), Boston, Massachusetts, us, 02298
Postdoctoral Research Fellow – Fischer Lab
Dana-Farber Cancer Institute
Boston, MA
Full Time
The Fischer Lab at Dana-Farber Cancer Institute is a Structural and Chemical Biology lab that combines molecular biology, computational biology, structural biology, and chemistry with various ‘Omics’ techniques such as proteomics to study the pathways and protein complexes involved in the regulation of protein abundance via the ubiquitin proteasome system that are often associated with human diseases, including cancer. The Fischer lab integrates structural biology, molecular biology and computational guided approaches to address fundamental questions about the mechanistic principles that govern signaling through the ubiquitin proteasome system.
Our laboratory is based at Dana-Farber Cancer Institute in Longwood Center and is an affiliate of the BCMP department at Harvard Medical School. We are affiliated with state of the art facilities for structural biology (cryo-EM, X-ray crystallography, NMR), chemistry, biophysics, cellular imaging, etc. and the lab also has expertise and equipment for mass spectrometry including Orbitrap Eclipse tribrid mass spectrometers. Join our highly interactive team of scientists, postdocs, graduate students, and technicians to work on understanding signaling through the ubiquitin proteasome pathway and leverage these insights to test new avenues for therapeutic development.
Responsibilities
The Fischer Lab (https://fischerlab.org/) seeks a highly motivated individual to join the team as a POSTDOCTORAL RESEARCH FELLOW who will work on biochemistry and structural biology projects addressing fundamental questions in our understanding of the ubiquitin system. While we consider various backgrounds, a strong interest in understanding how molecular machines work and the desire to tackle a major problem of great significance are absolutely essential.
Qualifications
Recent Ph.D. or equivalent degree in structural biology (X-ray crystallography, electron microscopy), biochemistry, biophysics, or molecular biology.
Proven ability to develop and execute complex structural biology projects.
Ability to collect and analyze experimental data, prepare research publications, and communicate results.
Ability to work in a collaborative and team environment.
Excellent oral and written capabilities.
Expertise in two or more of the following areas:
Expertise in recombinant protein expression and purification.
Experience with insect and/or mammalian expression systems.
Proficiency in data collection and structure determination for either X-ray or cryo-EM.
Experience with protein biophysical techniques.
In vitro biochemistry and enzyme kinetics.
Quantitative and computational skills.
For more information and to apply, please visit:
https://careers.dana-farber.org/postdoctoral-research-fellow-fischerlab_
#J-18808-Ljbffr
Dana-Farber Cancer Institute
Boston, MA
Full Time
The Fischer Lab at Dana-Farber Cancer Institute is a Structural and Chemical Biology lab that combines molecular biology, computational biology, structural biology, and chemistry with various ‘Omics’ techniques such as proteomics to study the pathways and protein complexes involved in the regulation of protein abundance via the ubiquitin proteasome system that are often associated with human diseases, including cancer. The Fischer lab integrates structural biology, molecular biology and computational guided approaches to address fundamental questions about the mechanistic principles that govern signaling through the ubiquitin proteasome system.
Our laboratory is based at Dana-Farber Cancer Institute in Longwood Center and is an affiliate of the BCMP department at Harvard Medical School. We are affiliated with state of the art facilities for structural biology (cryo-EM, X-ray crystallography, NMR), chemistry, biophysics, cellular imaging, etc. and the lab also has expertise and equipment for mass spectrometry including Orbitrap Eclipse tribrid mass spectrometers. Join our highly interactive team of scientists, postdocs, graduate students, and technicians to work on understanding signaling through the ubiquitin proteasome pathway and leverage these insights to test new avenues for therapeutic development.
Responsibilities
The Fischer Lab (https://fischerlab.org/) seeks a highly motivated individual to join the team as a POSTDOCTORAL RESEARCH FELLOW who will work on biochemistry and structural biology projects addressing fundamental questions in our understanding of the ubiquitin system. While we consider various backgrounds, a strong interest in understanding how molecular machines work and the desire to tackle a major problem of great significance are absolutely essential.
Qualifications
Recent Ph.D. or equivalent degree in structural biology (X-ray crystallography, electron microscopy), biochemistry, biophysics, or molecular biology.
Proven ability to develop and execute complex structural biology projects.
Ability to collect and analyze experimental data, prepare research publications, and communicate results.
Ability to work in a collaborative and team environment.
Excellent oral and written capabilities.
Expertise in two or more of the following areas:
Expertise in recombinant protein expression and purification.
Experience with insect and/or mammalian expression systems.
Proficiency in data collection and structure determination for either X-ray or cryo-EM.
Experience with protein biophysical techniques.
In vitro biochemistry and enzyme kinetics.
Quantitative and computational skills.
For more information and to apply, please visit:
https://careers.dana-farber.org/postdoctoral-research-fellow-fischerlab_
#J-18808-Ljbffr